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Sackler School of Graduate Biomedical Sciences

Emmanuel Pothos

Associate Professor of Immunology
Emmanuel Pothos

Emmanuel Pothos

Associate Professor of Immunology

Office phone: 617-636-6778
Lab phone: 617-636-3483
Campus: Boston
Office: M&V 716
Laboratory: 
M&V 716
Education: 
BA, Experimental Psychology, American College of Athens
BA, Philosophy, University of Athens
MA, PhD, Neuroscience, Princeton University
Postdoctoral Training, Columbia University
Research synopsis: 

Our laboratory studies cellular and molecular mechanisms of synaptic neurotransmission in the midbrain and its catecholaminergic projections because of our interest in the neurochemistry and molecular biology of catecholamine-related disorders. The current focus is on the study of the plasticity of CNS catecholamine quantal size as it relates to normal function and the pathogenesis, development and symptoms of feeding/body weight disorders (like dietary obesity), drug addiction, psychotic disorders and movement disorders (like Parkinson's disease). Contrary to previous dogmas, quantal size (the amount of neurotransmitter released per vesicle during exocytosis) is not invariant in CNS catecholamine systems and offers us the opportunity to pharmacologically intervene at the presynaptic level in order to block or inhibit a catecholamine-related abnormality.

Lab members: