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Sackler School of Graduate Biomedical Sciences

Recent Publications from the Kuperwasser Lab

Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C. 2019. Identification of FUBP1 as a long tail cancer driver and widespread regulator of tumor suppressor and oncogene alternative splicing. Cell Rep. 28: 3435-3449. Abstract

Gross KM*, Zhou W*, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C. 2019. Loss of Slug compromises DNA damage repair and accelerates stem cell aging in mammary epithelium. Cell Rep. 28: 394-407. (equal contribution) Abstract

Gupta PB, Pastushenko I, Skibinski A, Blanpain C, Kuperwasser C. 2019. Phenotypic plasticity: Driver of cancer initiation, progression, and therapy resistance. Cell Stem Cell 24: 65-78. Abstract

Montesion M, Williams ZH, Subramanian RP, Kuperwasser C, Coffin JM. 2018. Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites. Retrovirology 15: 57. Abstract

Miller DH, Jin DX, Sokol ES, Cabrera JR, Superville DA, Gorelov RA, Kuperwasser C, Gupta PB. 2018. BCL11B drives human mammary stem cell self-renewal in vitro by inhibiting basal differentiation. Stem Cell Reports 10: 1131-1145. Abstract

Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C. 2018. Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon. Sci Rep. 8: 1415. Abstract

Golden BO, Griess B, Mir S, Fitzgerald M, Kuperwasser C, Domann F, Teoh-Fitzgerald M. 2017. Extracellular superoxide dismutase inhibits hepatocyte growth factor-mediated breast cancer-fibroblast interactions. Oncotarget 8: 107390-107408. Abstract

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2017. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. 92(1) pii: e01258-17.  Abstract

Olsen SN, Wronski A, Castaño Z, Dake B, Malone C, De Raedt T, Enos M, DeRose YS, Zhou W, Guerra S, Loda M, Welm A, Partridge AH, McAllister SS, Kuperwasser C, Cichowski K. 2017. Loss of RasGAP tumor suppressors underlies the aggressive nature of luminal B breast cancers. Cancer Discov. 7: 202-217.  Abstract

Breindel JL, Skibinski A, Sedic M, Wronski-Campos A, Zhou W, Keller PJ, Mills J, Bradner J, Onder T, Kuperwasser C. 2017. Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L. Stem Cell Reports. 9: 943-955.  Abstract

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I. 2016. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials 116: 34-47.  Abstract

Zhou W, Ni TK, Wronski A, Glass B, Skibinski A, Beck A, Kuperwasser C. 2016. The SIRT2 deacetylase stabilizes Slug to control malignancy of basal-like breast cancer. Cell Rep. 17: 1302-1317. Abstract

Ni TK, Kuperwasser C. 2016. Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer. Elife 5. pii: e14730.   Abstract

Gross K, Wronski A, Skibinski A, Phillips S, Kuperwasser C. 2016. Cell fate decisions during breast cancer development. J Dev Biol. 4: 4.   Abstract

Xu K, Tian X, Oh SY, Movassaghi M, Naber SP, Kuperwasser C, Buchsbaum RJ. 2016. The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis. Breast Cancer Res. 18: 14.   Abstract

Sedic M, Kuperwasser C. 2016. BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer. Cell Cycle 15: 621-627.   Abstract

Arendt LM, Kuperwasser C. 2015. Working stiff: How obesity boosts cancer risk. Sci Transl Med. 7: 301fs34.   Abstract

Arendt LM, Kuperwasser C. 2015. Form and function: How estrogen and progesterone regulate the mammary epithelial hierarchy. J Mammary Gland Biol Neoplasia. 20: 9-25.  Abstract

Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto AM, Georgakoudi I. 2015. Rapid three-dimensional quantification of voxel-wise collagen fiber orientation. Biomed Opt Express 6: 2294-2310.  Abstract

Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Keller PJ, Glover E, Richardson AL, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Näär AM, Blasco MA, Hinds PW, Kuperwasser C. 2015. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 6:7505.   Abstract

Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Buchsbaum RJ, Kuperwasser C, Walt DR. 2015. Ultra-sensitive protein detection via single molecule arrays towards early stage cancer monitoring. Sci Rep. 5: 11034.  Abstract

Wronski A, Arendt LM, Kuperwasser C. 2015. Humanization of the mouse mammary gland. Methods Mol Biol. 1293: 173-186.  Abstract

Mazumdar S, Arendt LM, Phillips S, Sedic M, Kuperwasser C, Gill G. 2015. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS One 10: e0121281. Abstract

Skibinski A, Kuperwasser C. 2015. The origin of breast tumor heterogeneity. Oncogene 34: 5309-5316. Abstract

Phillips S, Kuperwasser C. 2014. SLUG: Critical regulator of epithelial cell identity in breast development and cancer. Cell Adh Migr. 8: 578-587. Abstract

Arendt LM, St Laurent J, Wronski A, Caballero S, Lyle SR, Naber SP, Kuperwasser C. 2014. Human breast progenitor cell numbers are regulated by WNT and TBX3. PLoS One 9:e111442. Abstract

Arendt LM, Keller PJ, Skibinski A, Goncalves K, Naber SP, Buchsbaum RJ, Gilmore H, Come SE, Kuperwasser C. 2014. Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast Cancer Res. 16: 453. Abstract

Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C. 2014. Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation. Stem Cell Reports. 2: 633-647. Abstract

Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel EA, Kuperwasser C, Tsichlis PN. 2014. NDY1/KDM2B functions as a master regulator of Polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Res. 74: 3935-3946. Abstract

Skibinski A, Breindel JL, Prat A, Galván P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. 2014. The hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep. 6: 1059-1072. Abstract

McCready J, Arendt LM, Glover E, Iyer V, Briendel JL, Lyle SR, Naber SP, Jay DG, Kuperwasser C. 2014. Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation. Breast Cancer Res. 16: R2. Abstract