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Sackler School of Graduate Biomedical Sciences

Daniel Jay

Professor of Developmental, Molecular & Chemical Biology
Daniel Jay

Daniel Jay

Professor of Developmental, Molecular & Chemical Biology

Office phone: 617-636-6714
Lab phone: 617-636-2957
Campus: Boston
Office: M&V 710A
Laboratory: 
M&V 710
Education: 
BS, Biochemistry & Chemistry, University of Toronto
PhD, Biochemistry & Molecular Biology, Harvard University
Postdoctoral Training, Harvard University
Research synopsis: 

We developed Chromophore-Assisted Laser Inactivation (CALI) to inactivate specific proteins in living cells at precise times and location. We used CALI with antibody libraries in a high throughput and automated fashion to discover new proteins that act in cancer cell invasiveness identified an extracellular form of Heat Shock Protein 90 (Hsp90) that acts to activate pro-invasive proteins in the tumor microenvironment to increase invasion, the first step in metastasis. We are currently pursuing how this activation occurs and whether inhibition of extracellular Hsp90 could be a novel treatment to reduce metastasis of breast cancer.

Lab members: