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Sackler School of Graduate Biomedical Sciences

Ralph Isberg

Professor of Molecular Biology & Microbiology
Ralph Isberg

Ralph Isberg

Professor of Molecular Biology & Microbiology

Office phone: 617-636-3993
Lab phone: 617-636-4092
Campus: Boston
Office: Jaharis 423
Laboratory: 
Jaharis 424A
Education: 
AB, Chemistry, Oberlin College
PhD, Microbiology, Harvard University
Postdoctoral Training, Stanford University
Research synopsis: 

Our research is directed toward answering three questions concerning the lifestyle of invasive bacterial pathogens: How are intracellular pathogens able to penetrate into normally nonphagocytic epithelial cells? What factors do intracellular bacteria encode that allow them to survive and grow within the normally hostile environment of macrophages? What role do factors that are important for bacterial-host cell interaction models play in an infection of the host? We perform genetic and biochemical experiments on two bacterial pathogens, the bacterium Yersinia pseudotuberculosis, and Legionella pneumophila, the causative agent of Legionnaire's disease pneumonia.