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Sackler School of Graduate Biomedical Sciences

Larry Feig

Professor of Developmental, Molecular & Chemical Biology
Larry Feig

Larry Feig

Professor of Developmental, Molecular & Chemical Biology

Office phone: 617-636-6956
Lab phone: 617-636-6955
Campus: Boston
Office: Jaharis 605
Laboratory: 
Jaharis 601
Education: 
BS, Chemical Engineering, Columbia University
MS, Chemical Engineering, MIT
PhD, Physiology, Harvard University
Postdoctoral Training, Dana Farber Cancer Institute
Research synopsis: 

My lab focuses on two related projects revealing the molecular mechanisms controlling the sex-dependent effects of stress across generations: The first investigates how the neuronal, calcium-sensitive activator of Ras, Ras-GRF1, regulates the HPA axis response to acute and chronic stress specifically in adolescent females. The second investigates a newly detected form of epigenetic inheritance that occurs in males exposed to social instability stress during adolescence. These mice transmit anxiety and sociability defects specifically to their female offspring across at least 3 generations. At present, we are investigating how sperm miRNAs function as mediators of this Lamarckian type of inheritance in mice, and whether a similar phenomenon occurs in men raised in abusive and/or dysfunctional families.

Lab members: