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Sackler School of Graduate Biomedical Sciences

Alexei Degterev

Associate Professor of Developmental, Molecular & Chemical Biology
Alexei Degterev

Alexei Degterev

Associate Professor of Developmental, Molecular & Chemical Biology

Office phone: 617-636-0491
Lab phone: 617-636-0495
Campus: Boston
Office: M&V 716B
Laboratory: 
M&V 716
Education: 
BS, Chemistry, Moscow State University
MS, Biochemistry, Moscow State University
PhD, Biochemistry, Boston University
Postdoctoral Training, Harvard Medical School
Research synopsis: 

My lab focuses on the investigation of the molecular mechanisms, physiologic and pathophysiological roles of regulated cell death. Regulated cell death comes in many forms from apoptosis to a rapidly expanding spectrum of non-apoptotic necrosis-like cell death mechanisms. These processes play critical roles during development and in adult organism homeostasis, for example, helping eliminate infected, damaged or transformed cells. Conversely, alterations in regulated cell death pathways lead to a variety of human pathologies from acute traumas and ischemia-reperfusion injuries to cancer and chronic inflammatory diseases. The major aims of our work are to understand how key players in these pathways mediate activation of cell death in different contexts, especially as part of protective innate immune responses, and to develop chemical probes and drug leads that can be used to interrogate and therapeutically modulate cell death processes.

Lab members: