Our research centers on understanding the biophysical signaling mechanisms responsible for the development of healthy and diseased myocardium. Using an array of approaches, we are designing new approaches to repair diseased or damaged myocardium. We are using whole organ decellularization to study the role that the local extracellular environment (matrix stiffness, morphology and composition) plays in the progression of myocardial disease and how it relates to the potential effectiveness of cell therapy based methods of cardiac repair. We are also studying physicochemical signaling mechanisms responsible for the development of healthy myocardium from cardiac precursor or stem/ progenitor cells. Lastly, we are working on design, development and evaluation of new methods for cardiac repair following myocardial infarction and heart failure, including the use of tissue engineered ventricular myocardium created in vitro for implantation in vivo.