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Student Publications

Publication in peer-reviewed journals is a very important part of graduate training. Publications by Molecular Microbiology students over the past five years are listed below. The names of student authors are in bold font.

2019

Holloway JR, Williams ZH, Freeman MM, Bulow U, Coffin JM. 2019. Gorillas have been infected with the HERV-K (HML-2) endogenous retrovirus much more recently than humans and chimpanzees. Proc Natl Acad Sci USA Epub ahead of print. Abstract

2018

Duncan MC, Forbes JC, Nguyen Y, Shull LM, Gillette RK, Lazinski DW, Ali A, Shanks RMQ, Kadouri DE, Camilli A. 2018. Vibrio cholerae motility exerts drag force to impede attack by the bacterial predator Bdellovibrio bacteriovorus. Nat Commun. 9: 4757. Abstract

Koenigsberg AL, Heldwein E. 2018. The dynamic nature of the conserved tegument protein UL37 of herpesviruses. J Biol Chem. Epub ahead of print. Abstract

Logsdon MM, Aldridge BB. 2018. Stable regulation of cell cycle events in Mycobacteria: Insights from inherently heterogeneous bacterial populations. Front Microbiol. 9:541. Abstract

Markey L, Shaban L, Green ER, Lemon KP, Mecsas J, Kumamoto CA. 2018. Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection. Gut Microbes Epub ahead of print. Abstract

Montesion M, Williams ZH, Subramanian RP, Kuperwasser C, Coffin JM. 2018. Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites. Retrovirology 15: 57. Abstract

Ribis JW, Fimlaid KA, Shen A. 2018. Differential requirements for conserved peptidoglycan remodeling enzymes during Clostridioides difficile spore formation. Mol Microbiol. Epub ahead of print. Abstract

Sekulovic O, Mathias Garrett E, Bourgeois J, Tamayo R, Shen A, Camilli A. Genome-wide detection of conservative site-specific recombination in bacteria. PLoS Genet. 14: e10007332. Abstract

Severin GB, Ramliden MS, Hawver LA, Wang K, Pell ME, Kieninger AK, Khataokar A, O'Hara BJ, Behrmann LV, Neiditch MB, Benning C, Waters CM, Ng WL. 2018. Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae. Proc Natl Acad Sci USA Epub ahead of print. Abstract

Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. 2018. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50: 85-92. Abstract

Shull LM, Camilli A. 2018. Transposon sequencing of Vibrio cholerae in the infant rabbit model of cholera. Methods Mol Biol. 1839: 103-116. Abstract

2017

Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA 2017. Cytosolic phospholipase A2α promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection. Infect Immun. 85: e00280-17. Abstract

Cokol M, Kuru N, Bicak E, Larkins-Ford J, Aldridge BB. 2017. Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis. Sci Adv. 3:e1701881. Abstract

de Jesús-Díaz DA, Murphy C, Sol A, Dorer M, Isberg RR. 2017. Host cell S phase restricts Legionella pneumophila intracellular replication by destabilizing the membrane-bound replication compartment. MBio 8: e02345-16. Abstract

Herwald SE, Zucchi PC, Tan S, Kumamoto CA.n 2017. The two transmembrane regions of Candida albicans Dfi1 contribute to its biogenesis. Biochem Biophys Res Commun. 488: 153-158. Abstract

Klein BA, Cornacchione LP, Collins M, Malamy MH, Duncan MJ, Hu LT. 2017. Using Tn-seq to identify pigmentation related genes of Porphyromonas gingivalis: Characterization of the role of a putative glycosyltransferase. J Bacteriol. 199: e00832-16.  Abstract

Koenigsberg AL, Heldwein EE. 2017. Crystal structure of the N-terminal half of the traffic controller UL37 from Herpes Simplex virus Type 1. J Virol. 91: e01244-17. Abstract

Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB. 2017. A parallel adder coordinates Mycobacterial cell-cycle progression and cell-size homeostasis in the context of asymmetric growth and organization. Curr Biol. 27: 3367-3374. Abstract

Mann KM, Huang DL, Hooppaw AJ, Logsdon MM, Richardson K, Lee HJ, Kimmey JM, Aldridge BB, Stallings CL. 2017. Rv0004 is a new essential member of the mycobacterial DNA replication machinery. PloS Genet. 13: e1007115. Abstract

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2018. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. J Virol 92: e01258-17.  Abstract

Nguyen GT, Green ER, Mecsas J. 2017. Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 7:373. Abstract

Richards AL, Sollars PJ, Pitts JD, Stults AM, Heldwein EE, Pickard GE, Smith GA. 2017. The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion. PLoS Pathog. 13: e1006741. Abstract

Yen M, Cairns LS, Camilli A. 2017. A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models. Nat Commun. 8: 14187. Abstract

2016

Curtis A, Blackburn JK, Smiley SL, Yen M, Camilli A, Alam MT, Ali A, Morris JG. 2016. Mapping to support fine scale epidemiological cholera investigations: A case study of spatial video in Haiti. Int J Environ Res Public Health 13 (2).  Abstract

Fleming E, Camilli A. 2016. ManLMN is a glucose transporter and central metabolic regulator in Streptococcus pneumoniae. Mol Microbiol. 102: 467-487.  Abstract

Flowers LJ, Bou Ghanem EN, Leong JM. 2016. Synchronous disease kinetics in a murine model for enterohemorrhagic E. coli infection using food-borne inoculation. Front Cell Infect Microbiol. 6:138.  Abstract

Green ER, Clark S, Crimmins GT, Mack M, Kumamoto CA, Mecsas J. 2016. Fis is essential for Yersinia pseudotuberculosis virulence and protects against reactive oxygen species produced by phagocytic cells during infection. PLoS Pathog. 12: e1005898.   Abstract

Hawver LA, Jung SA, Ng WL. 2016. Specificity and complexity in bacterial quorum-sensing systems. FEMS Microbiol Rev. 40: 738-752. Abstract

Jung SA, Hawver LA, Ng WL. 2016. Parallel quorum sensing signaling pathways in Vibrio cholerae. Curr Genet. 62: 255-260. Abstract

Khaperskyy DA, Schmaling S, Larkins-Ford J, McCormick C, Gaglia MM. 2016. Selective degradation of host RNA polymerase II transcripts by influenza A virus PA-X host shutoff protein. PLoS Pathog. 12: e1005427.  Abstract

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21: 169-181. Abstract

McDonough E, Kamp H, Camilli A. 2016. Vibrio cholerae phosphatases required for the utilization of nucleotides and extracellular DNA as phosphate sources. Mol Microbiol. 99: 453-469.  Abstract

Tyc KM, Herwald SE, Hogan JA, Pierce JV, Klipp E, Kumamoto CA. 2016. The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression. BMC Syst Biol. 10: 20.   Abstract

Wildschutte JH*, Williams ZH*, Montesion M, Subramanian RP, Kidd JM, Coffin JM. 2016. Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proc Natl Acad Sci USA 113: E2326-E2334. (* equal contribution) Abstract

2015

Asrat S, Davis KM, Isberg RR. 2015. Modulation of the host innate immune and inflammatory response by translocated bacterial proteins. Cell Microbiol. 17: 785-795. Abstract

Bhardwaj N, Montesion M, Roy F, Coffin JM. 2015. Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. Viruses 7: 939-968. Abstract

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN. 2015. The α-yocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 194: 1090-1099. Abstract

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.  Abstract

Burke HG, Heldwein EE 2015. Crystal structure of the human cytomegalovirus glycoprotein B. PLoS Pathog. 11: e1005227.  Abstract

Fleming E, Lazinski DW, Camilli A. 2015. Carbon catabolite repression by seryl phosphorylated HPr is essential to Streptococcus pneumoniae in carbohydrate rich environments. Mol Microbiol. 6: e00078-15. Abstract

Greene NG, Narciso AR, Filipe SR, Camilli A. 2015. Peptidoglycan branched stem peptides contribute to Streptococcus pneumoniae virulence by inhibiting pneumolysin release. PLoS Pathog. 11: e1004996. Abstract

Hempstead AD, Isberg RR 2015. Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response. Proc Natl Acad Sci USA 112: E6790-E6797.   Abstract

Jung SA, Chapman CA, Ng WL 2015. Quadruple quorum-sensing inputs control Vibrio cholerae virulence and maintain system robustness. PLoS Pathog. 11: e1004837. Abstract

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. 2015. Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol. 194: 1763-1775. Abstract

Klein BA, Chen T, Scott JC, Koenigsberg AL, Duncan MJ, Hu LT. 2015. Identification and characterization of a minisatellite contained within a novel miniature inverted-repeat transposable element (MITE) of Porphyromonas gingivalis Mob DNA 6:18.  Abstract

Klein BA, Duncan MJ, Hu LT. 2015. Defining essential genes and identifying virulence factors of Porphyromonas gingivalis by massively parallel sequencing of transposon libraries (Tn-seq). Methods Mol Biol. 1279:25-43. Abstract

Mitchell SL, Ismail AM, Kenrick SA, Camilli A. 2015. The VieB auxiliary protein negatively regulates the VieSA signal transduction system in Vibrio cholerae BMC Microbiol. 15: 59. Abstract

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. 2015. A single bacterial immune evasion strategy dismantles both MyD88 and TRIF signaling pathways downstream of TLR4. Cell Host Microbe 18: 682-693.   Abstract

2014

Asrat S, de Jesús DA, Hempstead AD, Ramabhadran V, Isberg RR. 2014. Bacterial pathogen manipulation of host membrane trafficking. Ann Rev Cell Dev Biol. 30: 79-109. Abstract

Asrat S, Dugan AS, Isberg RR 2014. The frustrated host response to Legionella pneumophila Is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. PLoS Pathog. 10: e1004229. Abstract

Baldwin M, Russo C, Li X, Chishti AH. 2014. Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis. Biochem Biophys Res Commun. 450: 1427-1432. Abstract

Bhardwaj N, Maldarelli F, Mellors J, Coffin JM. 2014. HIV-1 infection leads to increased transcription of HERV-K (HML-2) proviruses in vivo but not to increased virion production. J Virol. 88: 11108-11120. Abstract

Dalia AB, McDonough E, Camilli A. 2014. Multiplex genome editing by natural transformation. Proc Natl Acad Sci USA 111: 8937-8942. Abstract

Henzy JE, Gifford RJ, Johnson WE, Coffin JM. 2014. A novel recombinant retrovirus in the genomes of modern birds combines features of avian and mammalian retroviruses. J Virol. 88: 2398-2405. Abstract

Herwald SE, Kumamoto CA 2014. Candida albicans niche specialization: Features that distinguish biofilm cells from commensal cells. Curr Fungal Infect Rep. 8: 179-184. Abstract

McDonough E, Lazinski DW, Camilli A. 2014. Identification of in vivo regulators of the Vibrio cholerae xds gene using a high-throughput genetic selection. Mol Microbiol. 42:302-315. Abstract

Paczosa MK, Fisher ML, Maldonado-Arocho FJ, Mecsas J. 2014. Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection. Cell Microbiol. 16: 247-268. Abstract

Pitts JD, Klabis J, Richards AL, Smith GA, Heldwein EE. 2014. Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking. J Virol. 88: 5462-5473. Abstract

Seed KD, Yen M, Shapiro BJ, Hilaire IJ, Charles RC, Teng JE, Ivers LC, Boncy J, Harris JB, Camilli A. 2014. Evolutionary consequences of intra-patient phage predation on microbial populations. ELife 3:e03497. Abstract

Wildschutte JH, Ram D, Subramanian R, Stevens VL, Coffin JM. 2014. The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls. Retrovirology 12: 62. Abstract