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Student Publications

Publication in peer-reviewed journals is a very important part of graduate training. Publications by Genetics students over the past five years are listed below. The names of student authors are in bold font.


Bhattacharyya T, Walker M, Powers NR, Brunton C, Fine AD, Petkov PM, Handel MA. 2019. Prdm9 and meiotic cohesin proteins cooperatively promote DNA double-strand break formation in mammalian spermatocytes. Curr Biol. Epub ahead of print. Abstract

Fine AD, Ball RL, Fujiwara Y, Handel MA, Carter GW. 2019. Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis. Mol Biol Cell. Epub ahead of print. Abstract

Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A. 2019. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ. 26: 332-347. Abstract

Sol A, Lipo E, de Jesús-Díaz DA, Murphy C, Devereux M, Isberg RR. 2019. Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest. Proc Natl Acad Sci USA. Epub ahead of print. Abstract

Williams PA, Braine CE, Kizhatil K, Foxworth NE, Tolman NG, Harder JM, Scott RA, Sousa GL, Panitch A, Howell GR, John SWM. 2019. Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma. Mol Neurodegener. 14: 6. Abstract


Alexander CK, Cronin KL, Silver M, Gardner HL, London C 2018. The addition of metronomic chemotherapy does not improve outcome for canine splenic haemangiosarcoma. J Small Anim Pract. Epub ahead of print. Abstract

Benway CJ, Iacomini J. 2018. Defining a microRNA-mRNA interaction map for calcineurin inhibitor induced nephrotoxicity. Am J Transplant. 8: 796-809. Abstract

Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W. 2018. The neuroregenerative capacity of olfactory stem cells is not limitless: Implications for aging. J Neurosci. Epub ahead of print. Abstract

Neuner SM, Heuer SE, Huentelman MJ, O'Connell KMS, Kaczorowski CC. 2018. Harnessing genetic complexity to enhance translatability of Alzheimer's disease mouse models: A path toward precision medicine. Neuron Epub ahead of print. Abstract

Freytsis M, Baugh L, Liu Z, Georgakoudi I, Hinds PW, Black LD, Huggins GS. 2018. Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS One 13: e0190623. Abstract

Gardner HL, Rippy SB, Bear MD, Cronin KL, Heeb H, Burr H, Cannon CM, Penmetsa KV, Viswanadha S, Vakkalanka S, London CA. 2018. Phase I/II evaluation of RV1001, a novel PI3Kδ inhibitor, in spontaneous canine lymphoma. PLoS One 13: e0195357. Abstract

Kulkarni S, Goel S, Sengupta S, Cochran BH. 2018. A large-scale RNAi screen identifies SGK1 as a key survival kinase for GBM stem cells. Mol Cancer Res. 16: 103-114. Abstract

Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A. 2018. Constitutive interferon maintains GBP expression required for release of bacterial components upstream of pyroptosis and anti-DNA responses. Cell Rep. 24: 155-168. Abstract

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2018. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. 92: e01258-17.  Abstract

Montesion M, Williams ZH, Subramanian RP, Kuperwasser C, Coffin JM. 2018. Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites. Retrovirology 15: 57. Abstract

Neil AJ, Liang MU, Khristich AN, Shah KA, Mirkin SM. 2018. RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication. Nucleic Acids Res. Epub ahead of print. Abstract

Sadowski AR, Gardner HL, Borgatti A, Wilson H, Vail DM, Lachowicz J, Manley C, Turner A, Klein MK, Waite A, Sahora A, London CA. 2018. Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma. BMC Vet Res. 14: 250. Abstract

Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. 2018. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci USA. 115: E1088-E10897. Abstract

Sweeney MF, Sonnenschein C, Soto AM. 2018. Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D. Cancer Cell Int. 18: 43. Abstract


Khanna P, Maron JL, Walt DR. 2017. Development of a rapid salivary proteomic platform for oral feeding readiness in the preterm newborn. Front Pediatr. 5: 268. Abstract

McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T. 2017. Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genes. Front Immunol. 8: 1094. Abstract

McGinty RJ, Rubinstein RG, Neil AJ, Dominska M, Kiktev D, Petes TD, Mirkin SM. 2017. Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. Genome Res. 27: 2072-2082. Abstract

Neil AJ, Kim JC, Mirkin SM. 2017. Precarious maintenance of simple DNA repeats in eukaryotes. Bioessasy 39. doi: 10.1002/bies.201700077. Abstract

Radchenko EA, McGinty RJ, Aksenova AY, Neil AJ, Mirkin SM 2017. Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System. Methods Mol Biol. 1672: 421-428. Abstract

Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA. 2017. Nat Comm. 8: 15855. Abstract


Graham LC, Harder JM, Soto I, de Vries WN, John SW, Howell GR. 2016. Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease. Sci Rep. 6: 21568. Abstract

Gross K, Wronski A, Skibinski A, Phillips S, Kuperwasser C. 2016. Cell fate decisions during breast cancer development. J Dev Biol. 4: 4.   Abstract

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21: 169-181. Abstract

Leaderer D, Cashman SM, Kumar-Singh R. 2016. G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection. Exp Eye Res. 145: 380-392.   Abstract

Papageorgiou I, Freytsis M, Court MH. 2016. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochem Pharmacol. 117: 78-87. Abstract

Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291: 23188-23198. Abstract

Speroni L, Sweeney MF, Sonnenschein C, Soto AM. 2016. A hormone-responsive 3D culture model of the human mammary gland epithelium. J Vis Exp. (108): e53098. Abstract

Soto I, Grabowska WA, Onos KD, Graham LC, Jackson HM, Simeone SN, Howell GR. 2016. Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease. Neurobiol Aging 42: 50-60. Abstract

Sweeney MF, Hasan N, Soto AM, Sonnenschein C. 2015. Environmental endocrine disruptors: Effects on the human male reproductive system. Rev Endocr Metab Disord. 16: 341-357. Abstract

Weindel CG, Richey LJ, Mehta AJ, Shah M, Huber BT. 2016. Autophagy in dendritic cells and B cells is critical for the inflammatory state of TLR7-mediated autoimmunity. J Immunol. 198: 1081-1092.  Abstract

Wildschutte JH*, Williams ZH*, Montesion M, Subramanian RP, Kidd JM, Coffin JM. 2016. Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proc Natl Acad Sci USA 113: E2326-E2334. (* equal contribution) Abstract


Bhardwaj N, Montesion M, Roy F, Coffin JM. 2015. Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. Viruses 7: 939-968. Abstract

Gilbert MA, Lin B, Peterson J, Jang W, Schwob JE. 2015. Neuregulin1 and ErbB expression in the uninjured and regenerating olfactory mucosa. Gene Exp Patterns 19: 108-119. Abstract

Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW. 2015. The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A. 167: 1993-2008. Abstract

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. 2015. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 212: 287-295. Abstract

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR. 2015. DBA/2J Genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. PLoS One 10: e0125897. Abstract

Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, Roopenian DC, Morse HC 3rd. 2015. Am J Pathol. 185: 3102-3114. Abstract

Khanna P, Walt DR. 2015. Salivary diagnostics using a portable point-of-service platform: A review. Clin Ther. 37: 498-504. Abstract

Leaderer D, Cashman SM, Kumar-Singh R. 2015. Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59. J Gene Med. 17: 101-115. Abstract

Leaderer D, Cashman SM, Kumar-Singh R. 2015. Topical application of a G-quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration. Exp Eye Res. 140: 171-178.   Abstract

Luo C, Pietruska JR, Sheng J, Bronson RT, Hu MG, Cui R, Hinds PW. 2015. Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo. Pigment Cell Melanoma Res. 28: 603-606.  Abstract

Mazumdar S, Arendt LM, Phillips S, Sedic M, Kuperwasser C, Gill G. 2015. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS One 10: e0121281. Abstract

McDonald G, Cabal N, Vannier A, Umiker B, Yin RH, Orjalo AV Jr, Johansson HE, Han JH, Imanishi-Kari T. 2015. Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked Toll-like receptor 8. Front Immunol. 6: 457. Abstract

Soto I, Graham LC, Richter HJ, Simeone SN, Radell JE, Grabowska W, Funkhouser WK, Howell MC, Howell GR. 2015. APOE stabilization by exercise prevents aging neurovascular dysfunction and complement induction. PLoS Biol. 13: e1002279. Abstract

Sun X, Pinacho R, Saia G, Punko D, Meana JJ, Ramos B, Gill G. 2015. Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning. Dev Neurobiol. 75: 93-108. Abstract

Weindel CG, Richey LJ, Bolland S, Mehta AJ, Kearney JF, Huber BT. 2015. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy 11: 1010-1024.  Abstract

Yuan J, Benway CJ, Bagley J, Iacomini J. 2015. MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Am J Transplant. 15: 1682-1691. Abstract


Doyle JR, Harwood BN, Krishnaji ST, Krishnamurthy VM, Lin WE, Fortin JP, Kumar K, Kopin AS. 2014. A two-step strategy to enhance activity of low potency peptides. PLoS One 9: e110502. Abstract

Foley CJ, Kuliopulos A. 2014. Mouse matrix metalloprotease-1a (Mmp1a) gives new insight Into MMP function. J Cell Physiol. 229: 1875-1880. Abstract

Foley CJ, Fanjul-Fernández M, Bohm A, Nguyen N, Agarwal A, Austin K, Koukos G, Covic L, López-Otín C, Kuliopulos A. 2014. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogene 33: 2264-2272. Abstract

Harwood BN, Draper I, Kopin AS. 2014. Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability. Exp Cell Biol. 271: 4091-4098. Abstract

Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM. 2014. Development of an OP9 derived cell Line as a robust model to rapidly study adipocyte differentiation. PLoS One 9: e112123. Abstract

Phillips S, Kuperwasser C. 2014. SLUG: Critical regulator of epithelial cell identity in breast development and cancer. Cell Adh Migr. 8: 578-587. Abstract

Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C. 2014. Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation. Stem Cell Reports 2: 633-647.

Saia G, Lalonde J, Sun X, Ramos B, Gill G. 2014. Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling. J Neurochem. 129: 743-752. Abstract

Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z, Hu GF. 2014. Transcription of angiogenin and ribonuclease 4 is regulated by RNA Polymerase III elements and a CCCTC-binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem. 289: 12520-12534. Abstract

Sproule TJ, Bubier JA, Grandi FC, Sun VZ, Philip VM, McPhee CG, Adkins EB, Sundberg JP, Roopenian DC. 2014. Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice. PLoS Genet. 10: e1004068. Abstract

Umiker BR*, Andersson S*, Fernandez L, Korgaokar P, Larbi A, Pilichowska M, Weinkauf CC, Wortis HH, Kearney JF, Imanishi-Kari T. 2014. Dosage of X-linked toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus. Eur J Immunol. 44: 1503-1516. (*equal contribution) Abstract

Umiker BR, McDonald G, Larbi A, Medina CO, Reth M, Imanishi-Kari T. 2014. Production of IgG autoantibody requires expression of activation-induced deaminase in early developing B cells in a mouse model of SLE. Eur J Immunol. 44: 3093-3010. Abstract