Stephen Bunnell, PhD

Stephen Bunnell, PhD

Associate Professor of Integrative Physiology & Pathobiology

 

Education

BA, Biological Sciences, Cornell University
PhD, Biology, Harvard University
Postdoctoral Training, National Institutes of Health, Bethesda

Location

Campus: Boston
Office: Jaharis 5
Laboratory: Jaharis 524

Contact Information

Office Phone: 617-636-2174
Lab Phone: 617-636-2779
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Immunology

 

Research Synopsis

We are interested in the signaling complexes that control T cell differentiation and activation. Using advanced imaging techniques we examine the assembly and localization of these complexes in living T cells. The composition of these structures varies dynamically in a fashion that reflects the physiological constraints on T cell activation. We have shown that these structures cannot persist in the absence of any of several critical proteins. These proteins are therefore likely to form a cooperatively assembled core complex upon which complete signaling complexes are built. Finally, we have found that these complexes change in localization over time. We are currently defining the components of the core complex and are testing how changes in localization affect the generation of signals uniquely required for T cell activation.

 

Lab Members

Nicole Castagnozzi, PhD Student in Immunology Send an e-mail  Lab Research Page
Michael Fray, PhD Student in Immunology Send an e-mail  Lab Research Page
Michael Ophir, PhD Student in Immunology Send an e-mail  Lab Research Page
Joanne Russo, Senior Research Assistant  Send an e-mail

Application for 2015 Admission

The application for 2015 admissions will be available soon.