The Alan Kopin Lab

Research Publications Genetics Neuroscience Pharmacology

 

G Protein-coupled Receptor Function and Disease 

The Kopin laboratory has studied the molecular pharmacology of G protein-coupled receptors (GPCRs) for two decades. Special interests include: structure-function relationships, GPCR mediated physiology, polymorphism/ mutation induced alterations in function, and the development of tools for drug discovery.  Ongoing studies in the laboratory have clinical relevance in the areas of metabolic disease (i.e. obesity and diabetes), neurologic/locomotor dysfunction (e.g. Parkinson’s disease) and nociception (e.g. acute pain).

Current investigations are aimed at:  

  • understanding the molecular basis for peptide hormone- GPCR interaction and function,
  • exploring how genetic variation in selected receptors influences the onset and/or progression of disease,
  • studying the pharmacological properties and potential medical applications of membrane-tethered ligands, an innovative technology developed in the laboratory to modulate GPCR function,
  • generating recombinant protein activators of orphan GPCRs and
  • identifying novel compounds which mediate GPCR activity.

To accomplish these objectives, the laboratory utilizes molecular biologic tools, cell-based assays, as well as animal models (e.g. genetically altered mice and fruit flies).

Kopin Fig 1

Figure 1. This illustration depicts aspects related to two of our major research interests:  the effect of non-synonymous single nucleotide polymorphisms (SNP, shown as a filled green circle) on receptor function(Fortin et al, 2010 Abstract in PubMed) and membrane tethered ligands (MTL) as modulators of GPCR activity. The MTL shown is comprised of an intracellular fluorescent tag (red oval), a transmembrane domain anchor (grey rectangle), a protein linker which includes a Myc epitope tag followed by an extracellular peptide ligand at the N terminus (blue rectangle) (Fortin et al, 2009 Abstract in PubMed)

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December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research