Recent Publications from the Zeng Lab

Research Publications Cell Biology Immunology


Uchimura T, Hollander JM, Nakamura DS, Liu Z, Rosen CJ, Georgakoudi I, Zeng L. 2017. An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth. Development 144: 3533-3546. Abstract in PubMed

Gibson AL, Hui Mingalone CK, Foote AT, Uchimura T, Zhang M, Zeng L. 2017. Wnt7a inhibits IL-1β induced catabolic gene expression and prevents articular cartilage damage in experimental osteoarthritis. Sci Rep. 7: 41823.  Abstract in PubMed

Nakamura DS, Hollander JM, Uchimura T, Nielsen HC, Zeng L. 2017. Pigment epithelium-derived factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC Musculoskelet Disord. 18: 39.  Abstract in PubMed

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I. 2016. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials 116: 34-47.  Abstract in PubMed

Uchimura T, Foote AT, Markel DC, Ren W, Zeng L. 2016. The chondroprotective role of erythromycin in a murine joint destruction model. Cartilage 7(4):373-387. Abstract in PubMed

Tang X, Fan l, Pei M, Zeng L, Zigang G. 2015. Evolving concepts of chondrogenic differentiation: History, state-of-art and future perspectives. Eur Cell Mater. 30: 12-27. Abstract in PubMed

Uchimura T, Foote AT, Smith EL, Matzkin EG, Zeng L. 2015. Insulin-like growth factor II (IGF-II) inhibits IL-1β-induced cartilage matrix loss and promotes cartilage integrity in experimental osteoarthritis. J Cell Biochem. 116: 2858-2869. books

Leahy AA, Esfahani SA, Foote AT, Hui CK, Rainbow RS, Nakamura DS, Tracey BH, Mahmood U, Zeng L. 2015. Following the trajectory of osteoarthritis development through serial near infrared fluorescence imaging of MMP activities. Arthritis Rheumatol. 67: 442-453. books

Rainbow RS, Kwon H and Zeng L. 2014. Role of Nkx3.2 in chondrogenesis. Front Biol. 9: 376-387. books

Kwon H, Rainbow RS, Sun L, Hui CK, Cairns DM, Preda RC, Kaplan DL, Zeng L. 2014. Scaffold structure and fabrication method affect pro-inflammatory milieu in 3D-cultured chondrocytes. J Biomed Mater Res A 103: 534-544. books

Cairns DM, Pignolo RJ, Uchimura T, Brennan TA, Lindborg CM, Xu M, Kaplan FS, Shore EM, Zeng L.. 2013. Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. J Clin Invest. 123: 3624-3633. books

Rainbow RS, Kwon H, Foote AT, Preda RC, Kaplan DL, Zeng L. 2013. Muscle cell-derived factors inhibit inflammatory stimuli-induced damage in hMSC-derived chondrocytes. Osteoarthritis Cartilage. 21: 990-998. books

Kwon H, Sun L, Cairns DM, Rainbow RS, Preda RC, Kaplan DL, Zeng L. 2013. The influence of scaffold material on chondrocytes in inflammatory conditions. Acta Biomater. 9: 6563-6575. books

Cairns DM, Liu R, Sen M, Canner JP, Schindeler A, Little DG, Zeng L. 2012. Interplay of Nkx3.2, sox9 and pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS One 7: e39642. books

Rainbow R, Ren W, Zeng L. 2012. Inflammation and joint tissue interactions in OA: Implications for potential therapeutic approaches. Arthritis  2012: 741582. books

Brand JA, McAlindon TE, Zeng L. 2012.  A 3D system for culturing human articular chondrocytes in synovial fluid. J Vis Exp. 31: e3587. books

Cairns DM, Uchimura T, Kwon H, Lee PG, Seufert CR, Matzkin E, Zeng L. 2010. Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction. Biochem Biophys Res Commun. 392: 22-28. Abstract in PubMed

Cairns DM, Lee PG, Uchimura T, Seufert C, Kwon H, Zeng L. 2010. The role of muscle cells in regulating cartilage matrix production. J Orthop Res. 28: 529-536. Abstract in PubMed

Cairns DM, Sato ME, Lee, PG, Lassar AB, Zeng L. 2008. A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3. Dev Biol. 323: 152-165. Abstract in PubMed

Holowacz T, Zeng L, Lassar AB. 2006. Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Dev Dyn. 235: 633-645. Abstract in PubMed

Zeng, L, Kempf H, Murtaugh LC, Sato ME, Lassar AB. 2002. Shh establishes an Nkx3.2/Sox9 autoregulatory loop which is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev. 16: 1990-2005. Abstract in PubMed

Murtaugh LC*, Zeng L*, Chyung JH, Lassar AB. 2001. The chick transcriptional repressor Nkx3.2 acts downstream of Shh to promote BMP-dependent axial chondrogenesis. Dev Cell 1: 411-422. (* co-first author) Abstract in PubMed

Fagotto F, Jho Eh, Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F. 1999. Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J Cell Biol 145: 741-756. Abstract in PubMed

Hsu W, Zeng L, Costantini F. 1999. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J Biol Chem. 274: 3439-3445. Abstract in PubMed

Vasicek TJ, Zeng L, Guan XJ, Zhang T, Costantini F, Tilghman SM. 1997. Two dominant mutations in the mouse Fused gene are the result of transposon insertions. Genetics 147: 777-786. Abstract in PubMed

Zeng L*, Fagotto F*, Zhang T, Hsu W, Vasicek TJ, Perry III WL, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F. 1997. The fused gene regulates embryonic axis formation in mammals and amphibians, and encodes an inhibitor of the Wnt signaling pathway. Cell  90: 181-192. (* co-first author) Abstract in PubMed

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