Recent Publications from the Yang Lab

Research Publications Cell Biology


Morel L, Chiang MSR, Higashimori H, Shoneye T, Iyer LK, Yelick J, Tai A, Yang Y. 2017. Molecular and functional properties of regional astrocytes in the adult brain. J Neurosci. 37: 8706-8717.  Abstract in PubMed

Ng FS, Sengupta S, Huang Y, Yu AM, You S, Roberts MA, Iyer LK, Yang Y, Jackson FR. 2016. TRAP-seq profiling and RNAi-based genetic screens identify conserved glial genes required for adult Drosophila behavior. Front Mol Neurosci. 9: 146.  Abstract in PubMed

Higashimori H, Schin CS, Chiang MS, Morel L, Shoneye TA, Nelson DL, Yang Y. 2016. Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to Fragile X Syndrome phenotypes in vivo. J Neurosci. 36: 7079-7094. books

Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiol Dis. 91: 315-325. books

Ng SK, Higashimori H, Tolman M, Yang Y 2015. Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 267: 115-122. Abstract in PubMed

Armbruster M, Hampton D, Yang Y, Dulla CG. 2014. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Front Cell Neurosci. 8:277. Abstract in PubMed

Andresen L, Hampton D, Taylor A, Morel L, Yang Y, Maguire J, Dulla CG. 2014. Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Neurobiol Dis. 71: 305-316. Abstract in PubMed

Morel L, Higashimori H, Tolman M, Yang Y. 2014. VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci. 34: 10950-10962. Abstract in PubMed

Kawamata H, Ng SK, Diaz N, Burstein S, Morel L, Osgood A, Sider B, Higashimori H, Haydon PG, Manfredi G, Yang Y. 2014. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J Neurosci. 34: 2331-2348. Abstract in PubMed

Yang Y, Higashimori H, Morel L. 2013. Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders. J Neurodev Disord. 5 : 22. Abstract in PubMed

Morel L, Regan M, Higashimori H, Ng SK, Esau C, Vidensky S, Rothstein J, Yang Y. 2013. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem. 288: 7105-7116. Abstract in PubMed

Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, Freeman M, Yang Y. 2013. Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the Fragile X mouse. Hum Mol Genet. 22: 2041-2054.Abstract in PubMed

Higashimori H, Yang Y. 2012. Imaging analysis of neuron to glia interaction in microfluidic culture platform (MCP)-based neuronal axon and glia co-culture system. J Vis Exp. pii: 4448. Abstract in PubMed

Ghosh M, Yang Y, Rothstein JD, Robinson MB. 2011. Nuclear factor-kB contributes to neuron-dependent induction of GLT1 expression in astrocytes. J Neurosci. 31: 9159-9169. Abstract in PubMed

Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V, Kanthasamy AG. 2010. Alpha-synuclein negatively regulates PKC δ expression to suppress apoptosis in dopaminergic neurons by reducing p300 HAT activity. J Neurosci. 3: 2035-2051. Abstract in PubMed 

Yang Y, Vidensky S, Jin L, Jie C, Rothstein JD. 2010. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 59: 200-207. Abstract in PubMed

Yang Y, Gozen O, Vidensky S, Robinson MB, Rothstein JD. 2010. Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia 58: 277-286. Abstract in PubMed

Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Park JW, Jeon NL, Robinson MB, Rothstein JD. 2009. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron 61: 880-894. Abstract in PubMed

Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. 2008. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C δ: Implications for neurodegeneration in Parkinson’s disease. Mol Brain 1: 12. Abstract in PubMed

Sun F, Kanthasamy A, Song C, Yang Y, Anantharam V, Kanthasamy AG. 2008. Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKC δ proteolytic activation and mitochondrial translocation. J Cell Mol Med. 12: 2467-2481. Abstract in PubMed  

Schymick JC*, Yang Y*, Andersen PM*, Vonsattel JP, Greenway M, Momeni P, Elder J, Chio A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, Hutton M, Gass J, Cannon A, Rademakers R, Singleton AB, Hardiman O, Rothstein J, Hardy J, Traynor BJ. 2007. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis–frontotemporal dementia phenotypes. J Neurol Neurosurg Psychiatry 78:754-756. (*, these authors contributed equally to this work).  Abstract in PubMed

Zhang D, Kanthasamy A, Yang Y, Anantharam V, Kanthasamy AG. 2007. Protein Kinase C δ negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J Neurosci. 27: 5349-5372. Abstract in PubMed

Anantharam V, Lehrmann E, Kanthasamy A, Yang Y, Banerjee P, Becker KG, Freed WJ, Kanthasamy AG. 2007. Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochem Int. 50: 834-847. Abstract in PubMed  

Kaul S, Anantharam V, Yang Y, Choi CJ, Kanthasamy A, Kanthasamy AG. 2005. Tyrosine phosphorylation regulates the proteolytic activation of protein kinase C δ in dopaminergic neuronal cells. J Biol Chem. 280: 28721-30. Abstract in PubMed

Kitazawa M, Anantharam V, Yang Y, Hirata Y, Kanthasamy A, Kanthasamy AG. 2005. Activation of Protein kinase C δ by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochem Pharmacol. 69: 133-146. Abstract in PubMed

Latchoumycandane C, Anantharam V, Kitazawa M, Yang Y, Kanthasamy A, Kanthasamy AG. 2005. Protein kinase C δ is a key downstream mediator of manganese induced apoptosis. J Pharmacol Exp Ther. 313: 46-55. Abstract in PubMed

Yang Y, Kaul S, Zhang D, Anantharam V, Kanthasamy AG. 2004 Suppression of caspase-3 dependent proteolytic activation of protein kinase C δ by small interfering RNA (siRNA) prevents MPP+-induced dopaminergic degeneration. Mol Cell Neurosci. 25: 406-421. Abstract in PubMed

Kanthasamy AG, Kitazawa M, Kaul S, Yang Y, Lahiri DK, Anantharam V, Kanthasamy A. 2003. Proteolytic activation of pro-apoptotic kinase PKC δ is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. Ann NY Acad Sci. 1010: 683-686. Abstract in PubMed

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