Recent Publications from the Weinstock Lab

Research Publications Immunology


Elliott DE, Weinstock JV. 2016. Nematodes and human therapeutic trials for inflammatory disease. Parasite Immunol. Epub ahead of print. books

Hang L, Blum AM, Kumar S, Urban JF Jr, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. 2016. Downregulation of the Syk signaling pathway in intestinal dendritic cells is sufficient to induce dendritic cells that inhibit colitis. J Immunol. 197: 2948-2957. books

Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. 2015. Corrigendum to somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int. 2015: 869648. books

Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. 2014. Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int. 2014: 247182. books

Weinstock JV. 2014. Substance P and the regulation of inflammation in infections and inflammatory bowel disease. Acta Physiol (Oxf). 213: 453-461. books

Weinstock, JV. 2015. Do we need worms to promote immune health? Clin Rev Allergy Immunol. 49: 227-231. books

Weinstock JV, Elliott DE. 2014. Helminth infections decrease host susceptibility to immune-mediated diseases. J Immunol. 193: 3239-3247. books

Oxenkrug G, Turski W, Zgrajka W, Weinstock J, Ruthazer R, Summergrad P. 2014. Disturbances of tryptophan metabolism and risk of depression in HCV patients treated with IFN-. J Infect Dis Ther. 2. books

Hang L, Blum AM, Setiawan T, Urban JP Jr, Stoyanoff KM, Weinstock JV. 2013. Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitis. J Immunol. 191: 1927-1934. books

Weinstock JV. 2013. Have worms lost their luster? Imflamm Bowel Dis. 19: 672-673. books

Weinstock, JV, Elliott DE. 2013. Translatability of helminth therapy in inflammatory bowel diseases. Int J Parasitol. 43: 245-251. books

Weinstock, JV. 2012. Autoimmunity: The worm returns. Nature 491: 183-185. books

Elliott DE, Weinstock JV. 2012. Where are we on worms? Curr Opin Gastroenterol. 28: 551-556. books

Blum AM, Hang L, Setiawan T, Urban JP Jr, Stoyanoff KM, Leung J, Weinstock JV. 2012. Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut T cell responses. J Immunol. 189: 2512-2520. books

Elliott DE, Weinstock JV.  2012. Helminth-host immunological interactions: prevention and control of immune-mediated diseases. Ann NY Acad Sci. 1247: 83-96. books

Leung J, Hang L, Blum A, Setiawan T, Stoyanoff K, Weinstock J. 2012. Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease. Inflamm Bowel Dis. 18: 1447-1455. books

Walk ST, Blum AM, Ewing SA, Weinstock JV, Young VB. 2010. Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus. Inflamm Bowel Dis. 16: 1841-1849. books

Hang L, Setiawan T, Blum AM, Urban J, Stoyanoff K, Arihiro S, Reinecker HC, Weinstock JV. 2010. Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. J Immunol. 185: 3184-3189. books

Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV. 2010. TGF-β regulates T-cell neurokinin-1 receptor internalization and function. Proc Natl Acad Sci USA 107: 4293-4298. books

Summers RW, Elliott DE, Weinstock JV. 2010. Trichuris suis might be effective in treating allergic rhinitis. J Allergy Clin Immunol. 125: 766-767. books

Ruyssers NE, De Winter BY, De Man JG, Ruyssers ND, Van Gils AJ, Loukas A, Pearson MS, Weinstock JV, Pelckmans PA, Moreels TG. 2010. Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice. World J Gastroenterol 16: 703-712. books

Elliott DE, Weinstock JV. 2009. Helminthic therapy: using worms to treat immune-mediated disease. Adv Exp Biol Med. 666: 157-166. books

Clay BS, Shilling RA, Bandukwala HS, Moore TV, Cannon JL, Welcher AA, Weinstock JV, Sperling AI. 2009. Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. PLoS One 4: e7525. books

Tong J, Clay BS, Ferreira CM, Bandukwala HS, Moore TV, Blaine KM, Williams JW, Hoffman LM, Hamann KJ, Shilling RA, Weinstock JV, Sperling AI. 2009. FasL expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma. Am J Respir Cell Mol Biol. Epub ahead of print. books

Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI. 2009. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. Cell Immunol 259: 177-184. books

Ince MN, Elliott DE, Setiawan T, Metwali A, Blum A, Chen HL, Urban JF, Flavell RA, Weinstock JV. 2009. Role of T cell TGF-β signaling in intestinal cytokine responses and helminthic immune modulation. Eur J Immunol 39: 1870-1878. books

Weinstock JV, Elliott DE. 2009. Helminths and the IBD hygiene hypothesis. Inflamm Bowel Dis. 15: 491-500. books

Ruyssers NE, De Winter BY, De Man JG, Loukas A, Pearson MS, Weinstock JV, Van den Bossche RM, Martinet W, Pelckmans PA, Moreels TG. 2008. Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice. Inflamm Bowel Dis 15: 491-500. books

Bazzone LE, Smith PM, Rutitzky LI, Shainheit MG, Urban JF, Setiawan T, Blum AM, Weinstock JV, Stadecker MJ. 2008. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis. Infect Immun 76: 5164-5172. books

Elliott DE, Metwali A, Leung J, Setiawan T, Blum AM, Ince MN, Bazzone LE, Stadecker MJ, Urban JF Jr, and Weinstock JV. 2008. Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. J Immunol 181: 2414-2419. books

Tesciuba AG, Shilling RA, Agarwal MD, Bandukwala HS, Clay BS, Moore TV, Weinstock JV, Welcher AA, Sperling AI. 2008. ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes. J Immunol. 181: 1019-1024. books

Blum A, Setiawan T, Hang L, Stoyanoff K, Weinstock JV. 2008. IL12 and IL23 induction of substance P synthesis in murine T cells and macrophages is subject to IL10 and TGFβ regulation. Infect Immun. 76: 3651-3656. books

Bandukwala ,H. S., Clay, B. S., Tong, J., Mody, P. D., Cannon, J. L., Shilling, R. A., Verbeek, J. S., Weinstock, J. V., Solwa, J, Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204: 1875-1889. books

Setiawan T, Metwali A, Blum AM, Ince MN, Urban JF Jr, Elliott DE, Weinstock JV. 2007. Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine. Infect Immun 75: 4655-4663. books

Elliott DE, Summers RW, Weinstock JV. 2007. Helminths as governors of immune-mediated inflammation. Int J Parasitol 37: 457-464. books

Weinstock JV. 2006. Helminths and mucosal immune modulation. Ann NY Acad Sci 1072: 356-364. books

Reinke EK, Johnson MJ, Ling C, Karman J, Lee J, Weinstock JV, Sandor M, Fabry Z. 2006. Substance P receptor mediated maintenance of chronic inflammation in EAE. J Neuroimmunol 180: 117-125. books

Kitagaki K, Businga TR, Racila D, Elliott DE, Weinstock JV, Kline JN. 2006. Intestinal helminths protect in a murine model of asthma. J Immunol 177: 1628-1635. books

Metwali A, Setiawan T, Blum AM, Urban J, Elliott DE, Hang L, Weinstock JV. 2006. Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. Am J Physiol Gastrointest Liver Physiol 291: G253-259. books

Guarner F, Bourdet-Sicard R, Brandtzaeg P, Gill HS, McGuirk P, van Eden W, Versalovic J, Weinstock JV, Rook GA. 2006. Mechanisms of disease: the hygiene hypothesis revisited. Nat Clin Pract Gastroenterol Hepatol 3:275-284. books

Tong J, Bandulwala HS, Clay BS, Anders RA, Shilling RA, Balachandran DD, Chen B, Weinstock JV, Solway J, Hamann KJ, Sperling AI. 2006. Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma. J Exp Med 203: 1173-1184. books

Ince MN, Elliott DE, Setiawan T, Blum A, Metwali A, Wang Y, Urban JF, Jr Weinstock JV. 2006. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFβ after lipopolysaccharide stimulation. J Immunol (Cutting Edge) 176: 726-729. books

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