Recent Publications from the Ward Lab

Research Publications Immunology Microbiology


Cruz MS, AlarconFalconi TM, Hartwick MA, Venkat A, Ehrlich HY, Anandan S, Ward HD, Veeraraghavan B, Naumova EN. 2017. From hospitalization records to surveillance: The use of local patient profiles to characterize cholera in Vellore, India. PLoS One 12: e0182642. books

Ward HD. 2017. New tools for Cryptosporidium lead to new hope for Cryptosporidiosis. Trends Parasitol. Epub ahead of print. books

Vong M, Ludington JG, Ward HD, Nibert ML. 2017. Complete cryspovirus genome sequences from Cryptosporidium parvum isolate Iowa. Arch Virol. Epub ahead of print. books

DeCicco RePass MA, Chen Y, Lin Y, Zhou W, Kaplan DL, Ward HD. 2017. A novel bioengineered 3D human intestinal model for long-term infection of Cryptosporidium parvum. Infect Immun. Epub ahead of print. books

Kattula D, Jeyavelu N, Prabhakaran AD, Premkumar PS, Velusamy V, Venugopal S, Geetha JC, Lazarus RP, Das P, Nithyanandhan K, Gunasekaran C, Muliyil J, Sarkar R, Wanke C, Ajjampur SS, Babji S, Naumova EN, Ward HD, Kang G. 2016. Natural history of cryptosporidiosis in a birth cohort in southern India. Clin Infect Dis. Epub ahead of print. books

Dinh DM, Ramadass B, Kattula D, Sarkar R, Braunstein P, Tai A, Wanke CA, Hassoun S, Kane AV, Naumova EN, Kang G, Ward HD. 2016. Longitudinal analysis of the intestinal microbiota in persistently stunted young children in South India. PLoS One 11: e0155405.  books

Ludington JG, Ward HD. 2016. The Cryptosporidium parvum C-type lectin CpClec mediates infection of intestinal epithelial cells via interactions with sulfated proteoglycans. Infect Immun. 84: 1593-1602.  books

Kulinkina AV, Mohan VR, Francis MR, Kattula D, Sarkar R, Plummer JD, Ward H, Kang G, Balraj V, Naumova EN. 2016. Seasonality of water quality and diarrheal disease counts in urban and rural settings in south India. Sci Rep. 6: 20521.  books

Rogawski ET, Meshnick SR, Becker-Dreps S, Adair LS, Sandler RS, Sarkar R, Kattula D, Ward HD, Kang G, Westreich DJ. 2016. Reduction in diarrhoeal rates through interventions that prevent unnecessary antibiotic exposure early in life in an observational birth cohort. J Epidemiol Community Health 70: 500-505.  books

Rogawski ET, Westreich DJ, Adair LS, Becker-Dreps S, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick S, Kang G. 2015. Early life antibiotic exposure Is not associated with growth in young children of Vellore, India. J Pediatr. 167: 1096-102.e3.  books

Lazarus RP, Ajjampur SS, Sarkar R, Geetha JC, Prabakaran AD, Velusamy V, Naumova EN, Ward HD, Kang G. 2015. Serum anti-Cryptosporidial gp15 antibodies in mothers and children less than 2 years of age in India. Am J Trop Med Hyg. 95: 931-938.  books

Ludington JG, Ward HD. 2015. Systemic and mucosal immune responses to Cryptosporidium-vaccine development. Curr Topics Med Rep. 2: 171-180.  books

Collinet-Adler S, Babji S, Francis M, Kattula D, Premkumar PS, Sarkar R, Mohan VR, Ward H, Kang G, Balraj V, Naumova EN. 2015. Environmental factors associated with high fly densities and diarrhea in Vellore, India. Appl Environ Microbiol. 81: 6053-6058. books

Rogawski ET, Westreich DJ, Becker-Dreps S, Adair LS, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick SR, Kang G. 2015. Antibiotic treatment of diarrhoea is associated with decreased time to the next diarrhoea episode among young children in Vellore, India.Int J Epidemiol. 44: 978-987. books

Rogawski ET, Westreich D, Becker-Dreps S, Adair LS, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick SR, Kang G. 2015. The effect of early life antibiotic exposures on diarrheal rates among young children in Vellore, India. Pediatr Infect Dis. 34: 583-588. books

Dinh DM, Volpe GE, Duffalo C, Bhalchandra S, Tai AK, Kane AV, Wanke CA, Ward HD. 2015. The intestinal microbiota, microbial translocation and systemic inflammation in chronic HIV infection. J Infect Dis. 211: 19-27. books

Kattula D, Francis MR, Kulinkina A, Sarkar R, Mohan VR, Babji S, Ward HD, Kang G, Balraj V, Naumova EN. 2015. Environmental predictors of diarrhoeal infection for rural and urban communities in south India in children and adults. Epidemiol Infect. 143: 3036-3047. books

Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA Jr, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER. 2015. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. Lancet Infect Dis. 15: 85-94. books

Kane AV, Dinh DM, Ward HD. 2014. Childhood malnutrition and the intestinal microbiome. Pediatr Res. 77: 256-262. books

Kattula D, Sarkar R, Sivarathinaswamy P, Velusamy V, Venugopal S, Naumova EN, Muliyil J, Ward H, Kang G. 2014. The first 1000 days of life: prenatal and postnatal risk factors for morbidity and growth in a birth cohort in southern India. BMj Open 4: e005404. books

Sarkar R, Kattula D, Francis MR, Ajjampur SS, Prabakaran AD, Jayavelu N, Muliyil J, Balraj V, Naumova EN, Ward HD, Kang G. 2014. Risk factors for cryptosporidiosis among children in a semi urban slum in Southern India: A nested case-control study. Am J Trop Med. 91: 1128-1137. books

Kattula D, Sarkar R, Sivarathinaswamy P, Velusamy V, Venugopal S, Naumova EN, Muliyil J, Ward H, Kang G. 2014. The first 1000 days of life: prenatal and postnatal risk factors for morbidity and growth in a birth cohort in southern India. BMJ Open 4: e005404. books

Sarkar R, Tate JE, Ajjampur SS, Kattula D, John J, Ward HD, Kang G. 2014. Burden of diarrhea, hospitalization and mortality due to cryptosporidial infections in Indian children. PLoS Negl Trop Dis. 8:e3042. books

Wanyiri JW, Kanyi H, Maina S, Wang DE, Steen A, Ngugi P, Kamau T, Waithera T, O'Connor R, Gachuhi K, Wamae CN, Mwamburi M, Ward HD. 2014. Cryptosporidiosis in HIV/AIDS patients in Kenya: Clinical features, epidemiology, molecular characterization and antibody responses. Am J Trop Med Hyg. 91: 319-328. books

Wanyiri JW, Kanyi H, Maina S, Wang DE, Ngugi P, O'Connor R, Kamau T, Waithera T, Kimani G, Wamae CN, Mwamburi M, Ward HD. 2013. Infectious diarrhoea in antiretroviral therapy-naive HIV/AIDS patients in Kenya. Trans R Soc Trop Med Hyg. 107: 631-638. books

Bhalchandra S, Ludington J, Coppens I, Ward HD. 2013. Identification and characterization of CpClec, a novel C-type lectin domain-containing mucin-like glycoprotein of Cryptosporidium. Infect Immun. 81: 3356-3365. books

Bhat N, Wojczyk BS, DeCicco M, Castrodad C, Spitalnik S, Ward H. 2013. Identification of a family of four UDP-polypeptide N-acetylgalactosaminyl transferases in Cryptosporidium species. Mol Biochem Parasitol. 191: 24-27. books

Ehrenman K, Wanyiri JW, Bhat N, Ward HD, Coppens I. 2013. Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes. Cell Microbiol. 15: 1182-1197. books

Sarkar R, Ajjampur SS, Prabakaran AD, Geetha JC, Sowmyanarayanan TV, Kane A, Duara J, Muliyil J, Balraj V, Naumova EN, Ward H, Kang G. 2013. Cryptosporidiosis among children in an endemic semiurban community in southern India: does a protected drinking water source decrease infection? Clin Infect Dis. 47: 398-406. books

Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. 2013. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLoS Pathog. 9: e1003261. books

Sarkar R, Sivarathinaswamy P, Thangaraj B, Sindhu KN, Ajjampur SS, Muliyil J, Balraj V, Naumova EN, Ward H, Kang G. 2013. Burden of childhood diseases and malnutrition in a semi-urban slum in southern India. BMC Public Health 13: 87. books

Jagai JS, Sarkar R, Castronovo D, Kattula D, McEntee J, Ward H, Kang G, Naumova EN. 2012. Seasonality of rotavirus in South Asia: a meta-analysis approach assessing associations with temperature, precipitation, and vegetation index. PLoS One 7: e38168. books

Sarkar R, Ajjampur SS, Muliyil J, Ward H, Naumova EN, Kang G. 2012. Serum IgG responses and seroconversion patterns to Cryptosporidium gp15 among children in a birth cohort in south India. Clin Vaccine Immunol. 19: 849-855. books

Borad AJ, Allison GM, Wang D, Ahmed S, Karim MM, Kane AV, Moy J, Hibberd PL, Rao Ajjampur SS, Kang G, Calderwood SB, Ryan ET, Naumova E, Khan WA, Ward HD. 2012. Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh. Am J Trop Med Hyg. 86: 214-222. books

Sarkar R, Ajjampur SR, Ward HD, Kang G, Naumova EN. 2012. Analysis of human immune responses in quasi-experimental settings: Tutorial in biostatistics. BMC Med Res Methodol. 12: 1. books

Allison GM, Rogers KA, Borad A, Ahmed S, Karim MM, Kane AV, Hibberd PL, Naumova EN, Calderwood SB, Ryan ET, Khan WA, Ward HD. 2011. Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh. Am J Trop Med Hyg. 85: 97-104. books

Hira KG, Mackay MR, Hempstead AD, Ahmed S, Karim MM, O'Connor RM, Hibberd PL, Calderwood SB, Ryan ET, Khan WA, Ward HD. 2011. Genetic diversity of Cryptosporidium spp. from Bangladeshi children. J Clin Microbiol. 49: 2307-2310. books 

O'Connor RM, Shaffie R, Kang G, Ward HD. 2011. Cryptosporidiosis in patients with HIV/AIDS. AIDS 25: 549-560. books

Collinet-Adler S, Ward HD. 2010. Cryptosporidiosis: environmental, therapeutic, and preventive challenges. Eur J Clin Infect Dis. 29: 927-935. books

Egorov AI, Montuori Trimble LM, Ascolillo L, Ward HD, Levy DA, Morris RD, Naumova EN, Griffiths JK. 2010. Recent diarrhea is associated with elevated salivary IgG responses to Cryptosporidium in residents of an eastern Massachusetts community. Infection 38: 117-123. books

Pantenburg B, Castellanos-Gonzalez A, Dann SM, Connelly RL, Lewis DE, Ward HD, White AC Jr. 2010. Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells. Am J Trop Hyg. 82: 600-607. books

Chatterjee A, Banerjee S, Steffen M, O'Connor RM, Ward HD, Robbins PW, Samuelson J. 2010. Evidence for mucin-like glycoproteins that tether sporozoites of Cryptosporidium parvum to the inner surface of the oocyst wall. Eukarot Cell 9: 84-96. books

Ward HD. 2009. Intestinal protozoal parasites and diarrheal disease in Bangladesh. Clin Infect Dis 48:1198-12200. books

O'Connor RM, Burns PB, Ha-Ngoc T, Scarpato K, Khan W, Kang G, Ward H. 2009. Polymorphic mucin antigens CpMuc4 and CpMuc5 are integral to Cryptosporidium parvum infection in vitro. Eukaryot Cell 8: 461-469. books

Wanyiri JW, Techasintana P, O'Connor RM, Blackman MJ, Kim K, Ward HD. 2009. Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro. Eukaryot Cell 8: 470-477. books

Muchiri JM, Ascolillo L, Mugambi M, Mutwiri T, Ward HD, Naumova EN, Egorov AI, Cohen S, Else JG, Griffiths JK. 2009. Seasonality of Cryptosporidium oocyst detection in surface waters of Meru, Kenya as determined by two isolation methods followed by PCR. J Water Health 7: 67-75. books

O'Connor RM, Wanyiri JW, Cevallos AM, Priest JW, Ward HD. 2007. Cryptosporidium parvum glycoprotein gp40 localizes to the sporozoite surface by association with gp15. Mol Biochem Parasitol 156: 80-83. books

Bhat N, Joe A, PereiraPerrin M, Ward HD. 2007. Cryptosporidium p30, a galactose/N-acetylgalactosamine-specific lectin, mediates infection in vitro. J Biol Chem 282: 34877-34887. books

Preidis GA, Wang HC, Lewis DE, Castellanos-Gonzalez A, Rogers KA, Graviss EA, Ward HD, White AC Jr. 2007. Seropositive human subjects produce interferon gamma after stimulation with recombinant Cryptosporidium hominis gp15. Am J Trop Med Hyg 77:583-585. books

Wanyiri JW, O'Connor R, Allison G, Kim K, Kane A, Qiu J, Plaut AG. Ward HD. 2007. Proteolytic processing of the Cryptosporidium spp. glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity. Infect. Immun 75: 184-192. books

Wanyiri J, Ward HD. 2006. Molecular basis of Cryptosporidium-host cell interactions: Recent advances and future perspectives. Future Microbiol. 1:201-208. books

Stroup SE, Roy S, McHele J, Maro V, Ntabaguzi S, Siddique A, Kang G, Guerrant RL, Kirkpatrick BD, Fayer R, Herbein J, Ward H, Haque R, Houpt ER. 2006. Real-time PCR detection and speciation of Cryptosporidium infection using Scorpion probes. J Med Microbiol 55:1217-1222. books

Chhin S, Harwell JI, Bell JD, Rozycki G, Ellman T, Barnett JM, Ward H, Reinert SE, Pugatch D. 2006. Etiology of chronic diarrhea in antiretroviral-naive patients with HIV infection admitted to Norodom Sihanouk Hospital, Phnom Penh, Cambodia. Clin Infect Dis 43:925-932. books

Godiwala NT, Vandewalle A, Ward HD, Leav BA. 2006. Quantification of in vitro and in vivo Cryptosporidium parvum infection by using real-time PCR. Appl Environ Microbiol 72: 4484-4488. books

Muthusamy D, Rao SS, Ramani S, Monica B, Banerjee I, Abraham OC, Mathai DC, Primrose B, Muliyil J, Wanke CA, Ward HD, Kang G. 2006. Multilocus genotyping of Cryptosporidium sp. isolates from human immunodeficiency virus-infected individuals in South India. J Clin Microbiol 44: 632-634. books

Cohen S, Dalle F, Gallay A, Di Palma M, Bonnin A, Ward HD. 2006. Identification of Cpgp40/15 Type Ib as the predominant allele in isolates of Cryptosporidium spp. from a waterborne outbreak of gastroenteritis in South Burgundy, France. J Clin Microbiol 44: 589-591. books

Rogers KA, Rogers AB, Leav BA, Sanchez A, Vannier E, Uematsu S, Akira S, Golenbock D, Ward HD. 2006. MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice. Infect Immun 74: 549-556. books

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