Recent Publications from the Walt Lab

Research Publications Cell Biology
Genetics Neuroscience


Yang X, Hartman MR, Harrington KT, Etson CM, Fierman MB, Slonim DK, Walt DR. 2017. Using next-generation sequencing to explore genetics and race in the high school classroom. CBE Lif Sic Educ. 16: pii: ar22. doi: 10.1187/cbe.16-09-0281.  books

Cohen L, Walt DR. 2017. Single-molecule arrays for protein and nucleic acid analysis. Annu Rev Anal Chem Epub ahead of print.   books

Hartman MR, Harrington KT, Etson CM, Fierman MB, Slonim DK, Walt DR. 2016. Personal microbiomes and next-generation sequencing for laboratory-based education. FEMS Microbiol Lett. Epub ahead of print.   books

Mogalisetti P, Walt DR. 2016. Enzyme kinetics in femtoliter arrays. Methods Enzymol. 581: 541-560.   books

Nie S, Zhang H, Mayer KM, Oppenheim FG, Little FF, Greenberg J, Uluer AZ, Walt DR. 2015. Correlations of salivary biomarkers with clinical assessments in patients with cystic fibrosis. PLoS One 10: e0135237.   books

Wu D, Milutinovic MD, Walt DR. 2015. Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples. Analyst 140: 6277-6282.   books

Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Buchsbaum RJ, Kuperwasser C, Walt DR. 2015. Ultra-sensitive protein detection via single molecule arrays towards early stage cancer monitoring. Sci Rep. 5: 11034.  books

Khanna P, Walt DR. 2015. Salivary diagnostics using a portable point-of-service platform: A review. Clin Ther. 37: 498-504. books

Gaylord ST, Abdul-Aziz S, Walt DR. 2015. Single molecule arrays (Simoa) for the ultra-sensitive detection of the host immune response to dengue infection. J Clin Microbiol. 53: 1722-1724. books

Mogalisetti P, Walt DR. 2015. Stoichiometry of the α-complementation reaction of Escherichia coli β-galactosidase as revealed through single-molecule studies. Biochemistry 54: 1583-1588. books

Mayer KM, Shnipes J, Davis D, Walt DR. 2015. Catalytic kinetics of single gold nanoparticles observed via optical microwell arrays. Nanotechnology 26: 055704. books

Raz N, Danin-Poleg Y, Hayman RB, Bar-On Y, Linetsky A, Shmoish M, Sanjuán E, Amaro C, Walt DR, Kashi Y. 2014. Genome-Wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus Biotype 3. PLoS One 9: e114576. books

Kelley SO, Mirkin CA, Walt DR, Ismagilov RF, Toner M, Sargent EH. 2014. Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. Nat Nanotechnol. 9: 969-980. books

Warren AD, Gaylord ST, Ngan KC, Dumont Milutinovic M, Kwong GA, Bhatia SN, Walt DR. 2014. Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. J AM Chem Soc. 136: 13709-13714. books

Walt DR,. 2014. Protein measurements in microwells. Lab Chip 14: 3195-3200. books

Rojek MJ, Walt DR. 2014. Observing single enzyme molecules interconvert between activity states upon heating. PLoS One 9: e86224. books

Nie S, Henley WH, Miller SE, Zhang H, Mayer KM, Dennis PJ, Oblath EA, Alarie JP, Wu Y, Oppenheim FG, Little FF, Uluer AZ, Wang P, Ramsey JM, Walt DR. 2014. An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples. Lab Chip 14: 1087-1098. books

Little FF, Delgado DM, Wexler PJ, Oppenheim FG, Mitchell P, Feldman JA, Walt DR, Peng RD, Matsui EC. 2014. Little FF, Delgado DM, Wexler PJ, Oppenheim FG, Mitchell P, Feldman JA, Walt DR, Peng RD, Matsui EC. PLoS One 9: e84449. books

LaFratta CN, Pelse I, Falla JL, Liu Y, Palacios MA, Manesse M, Whitesides GM, Walt DR. Measuring atomic emission from beacons for long-distance chemical signaling. Anal Chem. 85: 8933-8936. books

Palacios MA, Lacy MM, Schubert SM, Manesse M, Walt DR. 2013. Assessing the stochastic intermittency of single quantum dot luminescence for robust quantification of biomolecules. Anal Chem. 85: 6639-6645. books

Song L, Shan D, Zhao M, Pink BA, Minnehan KA, York L, Gardel M, Sullivan S, Phillips AF, Hayman RB, Walt DR, Duffy DC. 2013. Direct detection of bacterial genomic DNA at sub-femtomolar concentrations using single molecule arrays. Anal Chem. 85: 1932-1939. books

Nie S, Benito-Peña E, Zhang H, Wu Y, Walt DR. 2013. Multiplexed fluorescent microarray for human salivary protein analysis using polymer microspheres and fiber-optic bundles. J Vis Exp. Oct 10. books

Manesse M, Phillips AF, Lafratta CN, Palacios MA, Hayman RB, Walt DR. 2013. Dynamic microbead arrays for biosensing applications. Lab Chip 13: 2153-2160. books

Walt DR. 2012. Optical methods for single molecule detection and analysis. Anal Chem. 85: 1258-1263. books

Zhang H, Nie S, Etson CM, Wang RM, Walt DR. 2012. Oil-sealed femtoliter fiber-optic arrays for single molecule analysis. Lab Chip 12: 2229-2239. books

Palacios MA, Benito-Peña E, Manesse M, Mazzeo AD, Lafratta CN, Whitesides GM, Walt DR. 2011. InfoBiology by printed arrays of microorganism colonies for timed and on-demand release of messages. Proc Natl Acad Sci USA 108: 16510-16514. books

Whitaker RD, Pember S, Wallace BC, Brodley CE, Walt DR. 2011. Single cell time-resolved quorum responses reveal dependence on cell density and configuration. J Biol Chem. 286: 21623-21632. books

Walt DR, Kuhlik A, Epstein SK, Demmer LA, Knight M, Chelmow D, Rosenblatt M, Bianchi DW. 2011. Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genet Med. 13: 63-66. books

Lafratta CN, Huh SP, Mallillin AC, Riviello PJ, Walt DR. 2010. Visualizing fluorescence: Using a homemade fluorescence "microscope" to view latent fingerprints on paper. Chem Educ. 87: 1105-1187. books

Walt DR. 2010. Bead-based optical fiber arrays for artificial olfaction. Curr Opin Chem Biol. 14: 767-770. books

Aernecke MJ, Walt DR. 2009. Detection and classification of ignitable liquid residues using a fluorescence-based vapor-sensitive microsphere array.J Forensic Sci. 55: 178-184. books

Webb MR, LaFratta CN, Walt DR. 2009. Chromatically resolved optical microscope (CROMoscope): a grating-based instrument for spectral imaging. Anal Chem. 81: 7309-7313. books

Aernecke MJ, Guo J, Sonkusale S, Walt DR. 2009. Design, implementation, and field testing of a portable fluorescence-based vapor sensor. Anal Chem. 81: 5281-5290. books

Konry T, Hayman RB, Walt DR. 2009. Microsphere-based rolling circle amplification microarray for the detection of DNA and proteins in a single assay. Anal Chem. 81: 5777-5782. books

Aernecke MJ, Walt DR. 2009. Temporally resolved fluorescence spectroscopy of a microarray-based vapor sensing system. Anal Chem. 81: 5762-5769. books

Gorris HH, Walt DR. 2009. Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies. J Am Chem Soc. 131: 6277-6282. books

Tam JM, Song L, Walt DR. 2009. DNA detection on ultrahigh-density optical fiber-based nanoarrays. Biosens Bioelectron 24: 2488-2493. books

Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Wexler PJ, Little FF, Walt DR. 2009. Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem. 81: 2106-2114. books

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