Recent Publications from the Tsichlis Lab

Research Publications Cell Biology Genetics Immunology

 

Peterson JN, Lin B, Shin J, Phelan PJ, Tsichlis P, Schwob JE, Bullock PA. 2017. The Replication of JCV DNA in the G144 oligodendrocyte cell line is dependent upon Akt. J Virol. Epub ahead of print.  books

Paraskevopoulou MD, Tsichlis PN. 2017. A perspective on AKT 25-plus years after its discovery. Sci Signal. 10(486). books

McNiel EA, Tsichlis PN. 2017. Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1. Signal Tansduct Target Ther Epub ahead of print.  books

Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH. 2017. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol. Epub ahead of print. books

Voulgarelis M, Tsichlis PN. 2016. Proline hydroxylation linked to Akt activation. Science 353: 870-871. books

Vyrla D, Nikolaidis G, Oakley F, Perugorria MJ, Tsichlis PN, Mann DA, Eliopoulos AG. 2016. TPL2 kinase is a crucial signaling factor and mediator of NKT effector cytokine expression in immune-mediated liver injury. J Immunol. 196: 4298-4310. books

Richardson ET, Shukla S, Sweet DR, Wearsch PA, Tsichlis PN, Boom WH, Harding CV. 2015. TLR2-dependent ERK signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells. Infect Immun. 83: 2242-2254. books

Kanellis DC, Bursac S, Tsichlis PN, Volarevic S, Eliopoulos AG. 2014. Physical and functional interaction of the TPL2 kinase with nucleophosmin. Oncogene 34: 2516-2526. books

Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. 2014. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett. 347: 204-211. books

Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel EA, Kuperwasser C, Tsichlis PN. 2014. NDY1/KDM2B functions as a master regulator of Polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Res. 74: 3935-3946. books

Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. 2014. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. PLoS Pathog. 10: e1004136. books

Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz OH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. 2014. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett. 347: 204-211. books

Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU. 2014. Stat5 regulates the PI3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol. 34: 1363-1377. books

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. 2014. Phosphoproteomics screen reveals Akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell 53: 577-590. books

Corum DG, Tsichlis PN, Muise-Helmericks RC. 2014. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J. 28: 395-407. books

McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A. 2013. TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. J Immunol. 191: 1732-1743. books

Kyrmizi I, Ioannou M, Hatziapostolou M, Tsichlis PN, Boumpas DT, Tassiulas I. 2013. Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice. J Leukoc Biol. 94: 751-757. books

Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. 2013. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res. 73: 4337-4348. books

Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG. 2013. Proc Natl Acad Sci USA 110: E1470-1479. books

Ezell SA, Tsichlis PN. 2012. Akt1, EMSY, BRCA2 and type I IFN signaling: A novel arm of the IFN response. Transcription 3: 305-309. books

Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. 2012. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci USA 109: 9517-9522. books

Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. 2012. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci USA 109: E1082-1091. books

Ezell SA, Polytarchou C, Hatziapostolou M, Guo A, Sanidas I, Bihani T, Comb MJ, Sourvinos G, Tsichlis PN. 2012. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Proc Natl Acad Sci USA. 109: E613-621. books

Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O'Keeffe M, Berzins SP, Belz GT, Grumont RJ, Banerjee A, Strasser A, Godfrey DI, Tsichlis PN, Gerondakis S. 2011. The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J. 31: 692-706. books

Hatziapostolou M, Koukos G, Polytarchou C, Kottakis F, Serebrennikova O, Kuliopulos A, Tsichlis PN. 2011. Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal. 4: ra55. books

Kottakis F, Polytarchou C, Foltopoulou P, Sanidas I, Kampranis SC, Tsichlis PN. 2011. FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Mol Cell. 43: 285-298. books

Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN. 2011. Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res. 71: 4720-4731. books

Perfield JW 2nd, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. 2011. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes 60:1168-1176. books

Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, Gerondakis S, Godfrey DI. 2011. Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway. Immunnol Cell Biol. 89: 294-303. books

Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. 2010. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell 39: 761-772. books

Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, Bulyk M, Tsichlis PN, Shirley Liu X, Struhl K. 2010. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17: 348-361. books

Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN. 2010. Ablation of tumor progression locus 2 promotes a type 2 Th cell response in ovalbumin-immunized mice. J. Immunol. 184: 105-113. books

Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT. 2009. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1β production. J Immunol. 183: 7984-7993. books

Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. 2009. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2: ra62. books

Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. 2009. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69: 7507-7511. books

Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. 2009. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. immunity 31: 220-231. books

Kaiser F, Cook D, Papoutsopoulou S, Rajsbaum R, Wu X, Yang HT, Grant S, Ricciardi-Castagnoli P, Tsichlis PN, Ley SC, O'Garra A. 2009. TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells. J Exp Med 206: 1863-1871. books

Kampranis SC, Tsichlis PN. 2009. Histone demethylases and cancer. Adv Cancer Res 102: 103-169. books

Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN. 2009. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci USA 106: 2641-2646. books

Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, Chang R, Guo Z, Dose M, Mao C, Tsichlis PN, Gounari F, Hinds PW. 2009. A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res 69: 810-818. books

Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ. 2008. Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med 205: 2803-2812. books

Polytarchou C, Pfau, R, Hatziapostolou M, Tsichlis PN. 2008. The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol Cell Biol 28: 7451-7464. books

Maroulakou IG, Oemler W, Naber SP, Klebba I, Kuperwasser C, Tsichlis PN. 2008. Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol 217: 468-477. books

Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC. 2008. VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J 22: 3264-3275. books

Hatziapostolou M, Polytarchou C, Panutsopulos D, Covic L, Tsichlis PN. 2008. Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration. Cancer Res. 68: 1851-1861. books

Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN,Tsichlis PN. 2008. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci USA 105, 2987-2992. books

Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. 2008. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci USA 105, 1907-1912. books

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