Recent Publications from the Thorley-Lawson Lab

Research Publications Genetics Immunology

 

Thorley-Lawson D, Deitsch KW, Duca KA, Torgbor C. 2016. The link between Plasmodium falciparum malaria and dndemic Burkitt's Lymphoma-New insight into a 50-year-old enigma. PLoS Pathog. 12: e1005331.  books

Thorley-Lawson DA. EBV persistence - Introducing the virus. Curr Top Microbiol Immunol. 390: 151-209. books

Qiu J, Smith P, Leahy L, Thorley-Lawson DA. 2015. The Epstein-Barr virus encoded BART miRNAs potentiate tumor growth In vivo. PLoS Pathog. 11: e1004561. books

Qiu J, Thorley-Lawson DA. EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells. Proc Natl Acad Sci USA 111: 11157-11162. books

Torgbor C, Awuah P, Deitsch K, Kalantari P, Duca KA, Thorley-Lawson DA. 2014. A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis. PLoS Pathog. 10: e1004170. books

Hawkins JB, Delgado-Eckert E, Thorley-Lawson DA, Shapiro M. 2013. The cycle of EBV infection explains persistence, the sizes of the infected cell populations and which come under CTL regulation. PLoS Pathog. 9: e1003685. books

Thorley-Lawson DA, Hawkins JB, Tracy SI, Shapiro M. 2013. The pathogenesis of Epstein-Barr virus persistent infection. Curr Opin Virol. 3: 227-232. books

Tracy SI, Kakalacheva K, Lünemann JD, Luzuriaga K, Middeldorp J, Thorley-Lawson DA. 2012. Persistence of Epstein-Barr virus in self-reactive memory B cells. J Virol. 86: 12330-12340. books

Smith PA, Merritt D, Barr L, Thorley-Lawson DA. 2011. An orthotopic model of metastatic nasopharyngeal carcinoma and its application in elucidating a therapeutic target that inhibits metastasis. Genes Cancer. 2: 1023-1033. books

Hawkins JB, Jones MT, Plassmann PE, Thorley-Lawson DA.  2011. Chemotaxis in densely populated tissue determines germinal center anatomy and cell motility: a new paradigm for the development of complex tissues. PLoS One. 6: e27650. books

Qiu J, Cosmopoulos K, Pegtel M, Hopmans E, Murray P, Middeldorp J, Shapiro M, Thorley-Lawson DA. 2011. A novel persistence associated EBV miRNA expression profile is disrupted in neoplasia. PLoS Pathog. 8: e1002193. books

Clute SC, Naumov YN, Watkin LB, Aslan N, Sullivan JL, Thorley-Lawson DA, Luzuriaga K, Welsh RM, Puzone R, Celada F, Selin LK. 2010. Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes. J Immunol. 185: 6753-6764. books

Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, Lindenberg JL, de Gruijl TD, Würdinger T, Middeldorp JM. 2010. Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci USA 107: 6328-6333. books

Roughan JE, Torgbor C, Thorley-Lawson DA. 2010. Germinal center B cells latently infected with Epstein-Barr virus proliferate extensively but do not increase in number. J Virol. 84: 1158-1168. books

Hadinoto V, Shapiro M, Sun CC, Thorley-Lawson DA. 2009. The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output. PLoS Pathog 5: e1000496. books

Roughan JE, Thorley-Lawson DA. 2009. The intersection of Epstein-Barr virus with the germinal center. J Virol 83: 3968-3976. books

Cosmopoulos K, Pegtel M, Hawkins J, Moffett H, Novina C, Middeldorp J, Thorley-Lawson DA. 2009. Comprehensive profiling of EBV microRNAs in nasopharyngeal carcinoma. J Virol 83: 2357-2367. books

Thorley-Lawson DA, Allday MJ. 2008. The curious case of the tumour virus: 50 years of Burkitt's lymphoma. Nat Rev Microbiol 6: 913-624. books

Shapiro M, Duca KA, Lee K, Delgado-Eckert E, Hawkins J, Jarrah AS, Laubenbacher R, Polys NF, Hadinoto V, Thorley-Lawson DA. 2008. A virtual look at Epstein-Barr virus infection: simulation mechanism. J Theor Biol 252: 633-648. books

Thorley-Lawson DA, Duca KA, Shapiro M. 2008. Epstein-Barr virus: a paradigm for persistent infection - for real and in virtual reality. Trends Immunol 29, 195-201. books

Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. 2008. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood 111: 1420-1427. books

Thorley-Lawson DL, Duca KA. 2007. Pathogens cooperate lymphomagenesis. Nat Med 13: 906-907. books

Sun CC, Thorley-Lawson D. 2007. Plasma cell-specific transcription factor XBP-1s binds to and transactivates Epstein-Barr virus BZLF1 promoter. J Virol 81: 13566-13577. books

Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. 2007. Influence of EBV on the peripheral blood memory B cell compartment. J Immunol 179: 3153-3160. books

Duca KA, Shiprio M, Delgado-Eckert E, Hadinoto V, Jarrah AS, Laubenbacher R, Lee K, Luzuriaga K, Polys NF, Thorley-Lawson D. 2007. A vitrual look at Epstein-Barr virus infection: Biological interpretation. Plos Pathog 3: 1388-1400. books

Castiglione F, Duca K, Jarrah A, Laubenbacher R, Hochberg D, Thorley-Lawson D. 2007. Simulating Epstein-Barr virus infection with C-ImmSim. Bioinformatics 23: 1371-1377. books

Pegtel DM, Subramanian A, Merritt D, Tsai CH, Sheen TS, Golub TR, Thorley-Lawson DA. 2007. IFN-α-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas. Cancer Res 67: 474-481. books

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