Recent Publications from the Theoharides Lab

Research Publications Cell Biology Pharmacology

 

Conti P, Caraffa A, Ronconi G, Kritas SK, Mastrangelo F, Tettamanti L, Theoharides TC. 2017. Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37. Eur J Pharmacol. Epub ahead of print.  Abstract in PubMed

Conti P, Carinci F, Caraffa A, Ronconi G, Lessiani G, Theoharides TC. 2017. Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines. Med Hypotheses 106: 10-14.  Abstract in PubMed

Conti P, Carinci F, Lessiani G, Spinas E, Kritas SK, Ronconi G, Caraffa A, Theoharides TC. 2017. Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells. Immunol Res. Epub ahead of print.   Abstract in PubMed

Conti P, Caraffa A, Kritas SK, Ronconi G, Lessiani G, Toniato E, Theoharides TC. 2017. Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues. J Biol Regul Homeost Agents 31: 263-267.   Abstract in PubMed

Patel AB, Theoharides TC. 2017. Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J Pharmaol Exp Ther. 361: 462-471.   Abstract in PubMed

Theoharides TC. 2017. Vitamin D and atopy. Clin Ther. Epub ahead of print.  Abstract in PubMed

Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. 2017. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci USA Epub ahead of print.   Abstract in PubMed

Conti P, Lessiani G, Kritas SK, Ronconi G, Caraffa A, Theoharides TC. 2017. Mast cells emerge as mediators of atherosclerosis: Special emphasis on IL-37 inhibition. Tissue Cell Epub ahead of print.   Abstract in PubMed

Theoharides TC. 2017. Neuroendocrinology of mast cells: Challenges and controversies. Exp Dermatol. Epub ahead of print.   Abstract in PubMed

Patel AB, Tsilioni I, Leeman SE, Theoharides TC. 2016. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci USA Epub ahead of print.   Abstract in PubMed

Palaska I, Gagari E, Theoharides TC. 2016. The effects of P. gingivalis and E. coli LPS on the expression of proinflammatory mediators in human mast cells and their relevance to periodontal disease. J Biol Regul Homeost Agents. 30: 655-664.  Abstract in PubMed

Theoharides TC, Tsilioni I, Patel AB, Doyle R. 2016. Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders. Transl Psychiatry. 6: e844.  Abstract in PubMed

Caraffa A, Spinas E, Kritas SK, Lessiani G, Ronconi G, Saggini A, Antinolfi P, Pizzicannella J, Toniato E, Theoharides TC, Conti P. 2016. Endocrinology of the skin: intradermal neuroimmune network, a new frontier. J Biol Regul Homeost Agents 30: 349-353.   Abstract in PubMed

Theoharides TC, Stewart JM, Taracanova A, Conti P, Zouboulis CC. 2016. Neuroendocrinology of the skin. Rev Endocr Meab Disorders Epub ahead of print.  Abstract in PubMed

Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng Y, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan-Nabzdyk L, Theoharides TC, Veves A. 2016. Mast cells regulate wound healing in diabetes. Diabetes Epub ahead of print.  Abstract in PubMed

Weng Z, Zhang B, Tsilioni I, Theoharides TC. 2016. Nanotube formation: A rapid form of "alarm signaling"? Clin Ther. pii: S0149-2918(16)30127-8.  Abstract in PubMed

Theoharides, TC. 2016. Danger signals and inflammation. Clin Ther. pii: S0149-2918(16)30182-5.  Abstract in PubMed

Theoharides TC, Stewart JM. 2016. Post-Lyme syndrome-associated polyneuropathy treated with immune immunoglobulin and a luteolin-containing formulation. J Clin Pharmacol. 36: 290-291.   Abstract in PubMed

Theoharides TC. 2016. Skin mast cells: Are we missing the forest for the trees? Exp Dermatol. Epub ahead of print.   Abstract in PubMed

Theoharides TC, Stewart JM. 2016. Antihistamines and mental status. J Clin Pharmacol. 36: 195-197.   Abstract in PubMed

Tsilioni I, Russell IJ, Stewart JM, Gleason RM, Theoharides TC. 2016. Substance P, Hemokinin-1, CRH, TNF and IL-6 are increased in serum of patients with Fibromyalgia Syndrome and may serve both as biomarkers and targets for treatment. J Pharmacol Exp Ther. 356: 664-672.   Abstract in PubMed

Tsilioni I, Taliou A, Francis K, Theoharides TC. 2015. Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6. Transl Psychiatry. 5: e647.  Abstract in PubMed

Polyzoidis S, Koletsa T, Panagiotidou S, Ashkan K, Theoharides TC 2015. Mast cells in meningiomas and brain inflammation. J Neuroinflammation 12: 170. Abstract in PubMed

Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. 2015. Fibromyalgia, a syndrome in search of pathogenesis and therapy. J Pharmacol Exp Ther. 355: 255-263.  Abstract in PubMed

Theoharides TC, Stewart JM. 2015. Genitourinary mast cells and survival. Transl Androl Urol. 4: 579-586.  Abstract in PubMed

Theoharides TC, Valent P, Akin C. 2015. Mast Cells, mastocytosis, and related disorders. N Engl J Med. 373: 163-72. Abstract in PubMed

Theoharides TC, Stewart JM, Hatziagelaki E, Kolaitis G. 2015. Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci. 9: 225.  Abstract in PubMed

Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC. 2015. Gut-microbiota-brain axis and Its effect on neuropsychiatric disorders with suspected immune dysregulation. Clin Ther. 37: 984-995. Abstract in PubMed

Theoharides TC. 2015. On the gut microbiome-brain zxis and altruism. Clin Ther. 37: 937-940.  Abstract in PubMed

Theoharides TC, Petra AI, Taracanova A, Panagiotidou S, Conti P. 2015. Targeting IL-33 in autoimmunity and inflammation. J Pharmacol Exp Ther. 354: 24-31. Abstract in PubMed

Theoharides TC, Stewart JM, Panagiotidou S, Melamed I. 2015. Mast cells, brain inflammation and autism. Eur J Pharmacol. 778: 96-102. Abstract in PubMed

Theoharides TC. 2015. Mast cells promote malaria infection? Clin Ther. 37: 1374-1377. Abstract in PubMed

Theoharides TC, Athanassiou M, Panagiotidou S, Doyle R. 2015. Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders. J Nueroimmunol. 279C: 33-38. Abstract in PubMed

Weng Z, Patel AB, Panagiotidou S, Theoharides TC. 2014. The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J Allergy Clin Immunol. 135: 1044-1052. Abstract in PubMed

Tsilioni I, Dodman N, Petra AI, Taliou A, Francis K, Moon-Fanelli A, Shuster L, Theoharides TC. 2014. Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism. Transl Psychiatry 4: e466. Abstract in PubMed

Vasiadi M, Newman J, Theoharides TC. 2014. Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome. J Neuroinflammation 11: 168. Abstract in PubMed

Karamitopoulou E, Shoni M, Theoharides TC 2014. Increased number of non-degranulated mast cells in pancreatic ductal adenocarcinoma but not in acute pancreatitis. Int J Immunopathol Pharmacol. 27: 213-220. Abstract in PubMed

Tsilioni I, Panagiotidou S, Theoharides TC. 2014. Exosomes in neurologic and psychiatric disorders. Clin Ther. 4: e446. Abstract in PubMed

Alevizos M, Karagkouni A, Kontou-Fili K, Theoharides TC. 2014. A probable case of stress-induced anaphylaxis. Ann Allergy Asthma Immunol. 112: 383-384. Abstract in PubMed

Alevizos M, Karagkouni A, Panagiotidou S, Vasiadi M, Theoharides TC. 2014. Stress triggers coronary mast cells leading to cardiac events. Ann Allergy Asthma Immunol. 112: 309-316. Abstract in PubMed

Petra AI, Panagiotidou S, Stewart JM, Conti P, Theoharides TC. 2014. Spectrum of mast cell activation disorders. Exp Rev Clin Immunol. 10: 729-739. Abstract in PubMed

Alhelal MA, Palaska I, Panagiotidou S, Letourneau R, Theoharides TC. 2014. Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability. Ann Allergy Asthma Immunol. 112: 40-45. Abstract in PubMed

Weng Z, Patel AB, Vasiadi M, Therianou A, Theoharides TC. 2014. Luteolin inhibits human keratinocyte activation and decreases NF-κB induction that is increased in psoriatic skin. PLoS One 9: e90739. Abstract in PubMed

Theoharides TC, Conti P, Economu M. 2014. Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin. J Clin Psychopharmacol. 34: 187-189. Abstract in PubMed

Theoharides TC. 2014. Mast cells in irritable bowel syndrome and ulcerative colitis: Function not numbers is what makes all the difference. Dig Dis Sci. 59: 897-898. Abstract in PubMed

Miniati A, Weng Z, Zhang B, Therianou A, Vasiadi M, Nicolaidou E, Stratigos AJ, Antoniou C, Theoharides TC. 2014. Stimulated human melanocytes express and release interleukin-8, which is inhibited by luteolin: relevance to early vitiligo. Clin Exp Dermatol. 39: 54-57. Abstract in PubMed

Alhelal MA, Palaska I, Panagiotidou S, Letourneau R, Theoharides TC. 2014. Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability. Ann Allergy Asthma Immunol. 112: 40-45. Abstract in PubMed

Papathanasiou E, Flavia T, Griffin T, Arguello E, Finkelman M, Hanley J, Theoharides TC. 2014. Gingival crevicular fluid levels of interferon-γ, but not interleukin-4 or -33 or thymic stromal lymphopoietin, are increased in inflamed sites in patients with periodontal disease. J Periodontal Res. 49: 55-61. Abstract in PubMed

Alevizos M, Karagkouni A, Vasiadi M, Sismanopoulos N, Makris M, Kalogeromitros D, Theoharides TC. 2013. Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. Ann Allergy Asthma Immunol. 111: 542-547. Abstract in PubMed

Kritas SK, Saggini A, Varvara G, Murmura G, Caraffa A, Antinolfi P, Toniato E, Pantalone A, Neri G, Frydas S, Rosati M, Tei M, Speziali A, Saggini R, Pandolfi F, Cerulli G, Theoharides TC. 2013. Impact of mast cells on the skin. Int J Immunopathol Pharmacol. 26: 855-859. Abstract in PubMed

Alevizos M, Karagkouni A, Panagiotidou S, Vasiadi M, Theoharides TC. 2013. Stress triggers coronary mast cells leading to cardiac events. Ann Allergy Asthma Immunol. pii: S1081-1206(13)00691-1. Abstract in PubMed

Kritas SK, Saggini A, Varvara G, Murmura G, Caraffa A, Antinolfi P, Toniato E, Pantalone A, Neri G, Frydas S, Rosati M, Tei M, Speziali A, Saggini R, Pandolfi F, Cerulli G, Theoharides TC, Conti P. 2013. Luteolin inhibits mast cell-mediated allergic inflammation. J Biol Regul Homeost Agents. 27: 955-959. Abstract in PubMed

Alevizos M, Karagkouni A, Kontou-Fili K, Theoharides TC. 2013. A probable case report of stress-induced anaphylaxis. Ann Allergy Asthma Immunol. pii: S1081-1206(13)00501-2. Abstract in PubMed

Alevizos M, Karagkouni A, Vasiadi M, Sismanopoulos N, Makris M, Kalogeromitros D, Theoharides TC. 2013. Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. Ann Allergy Asthma Immunol. 111: 542-547. Abstract in PubMed

Palaska I, Papathanasiou E, Theoharides TC. 2013. Use of polyphenols in periodontal inflammation. Eur J Pharmacol. 720: 77-83. Abstract in PubMed

Papathanasiou E, Palaska I, Theoharides TC.2013. Stress hormones regulate periodontal inflammation. J Biol Regul Homeost Agents 27: 621-626. Abstract in PubMed

Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. 2013. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 169: 695-699. Abstract in PubMed

Theoharides, TC. 2013. Extracellular mitochondrial ATP, suramin, and autism? Clin Ther. 35: 1454-1456. Abstract in PubMed

Theoharides TC, Asadi S, Panagiotidou S, Weng Z. 2013. The "missing link" in autoimmunity and autism: Extracellular mitochondrial components secreted from activated live mast cells. Autoimmun Rev. 12: 1136-1142. Abstract in PubMed

Theoharides, TC. 2013. Is a subtype of autism an allergy of the brain? Clin Ther. 35: 584-591. Abstract in PubMed

Mavrommati D, Theoharides TC. 2013. Dietary interventions for atopic disorders. Curr Pharm Des. 20: 996-1002. Abstract in PubMed

Theoharides TC. 2013. Atopic conditions in search of pathogenesis and therapy. Clin Ther. 35 544-547. Abstract in PubMed

Theoharides TC, Asadi S, Patel AB. 2013. Focal brain inflammation and autism. J Neuroinflammation. 10: 46. Abstract in PubMed

Karagkouni A, Alevizos M, Theoharides TC. 2013. Effect of stress on brain inflammation and multiple sclerosis. Autoimmun Rev. 12: 947-953. Abstract in PubMed

Zhang B, Asadi S, Weng Z, Sismanopoulos N, Theoharides TC. 2012. Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions. PLoS One 7: e49767. Abstract in PubMed

Alysandratos KD, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, Critchfield A, Theoharides TC. Neurotensin and CRH interactions augment human mast cell activation. PLoS One 7: e48934. Abstract in PubMed

Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. 2012. Perinatal stress, brain inflammation and risk of autism-Review and proposal. BMC Pediatrics 12: 89. Abstract in PubMed

Theoharides TC, Enakuaa S, Sismanopoulos N, Asadi S, Papadimas EC, Angelidou A, Alysandratos KD. 2012. Contribution of stress to asthma worsening through mast cell activation. Ann Allergy Asthma Immunol. 109: 14-19. Abstract in PubMed

Theoharides TC, Asadi S. 2012. Unwanted interactions among psychotropic drugs and other treatments for autism spectrum disorders. J Clin Psychopharmacol. 32: 437-440. Abstract in PubMed

Asadi S, Theoharides TC. 2012. Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. J Neuroinflammation 9: 85. Abstract in PubMed

Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD, Angelidou A, Shirihai O, Theoharides TC. 2012. Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 159: 23-32. Abstract in PubMed

Theoharides TC, Asadi S, Chen J, Huizinga JD. 2012. Inflammatory bowel syndrome and the elusive mast cell. Am J Gastroenterol. 107: 727-729. Abstract in PubMed

Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. 2012. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One 7: e33805. Abstract in PubMed

Sismanopoulos N, Delivanis DA, Alysandratos KD, Angelidou A, Vasiadi M, Therianou A, Theoharides TC. 2012. IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis. PLoS One 7: e33271. Abstract in PubMed

Vasiadi M, Therianou A, Sideri K, Smyrnioti M, Sismanopoulos N, Delivanis DA, Asadi S, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Antoniou C, Papadavid E, Stavrianeas N, Kalogeromitros D, Theoharides TC.  2012. Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis. J Allergy Clin Immunol. 129: 1410-1413. Abstract in PubMed

Vasiadi M, Therianou A, Alysandratos KD, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Papadavid E, Stavrianeas N, Antoniou C, Kalogeromitros D, Theoharides TC. 2012. Serum neurotensin (NT) is increased in psoriasis and NT induces VEGF release from human mast cells. Br J Dermatol. 166: 1349-1352. Abstract in PubMed

Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. 2012. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One 7: e33805. Abstract in PubMed

Asadi S, Alysandratos KD, Angelidou A, Miniati A, Sismanopoulos N, Vasiadi M, Zhang B, Kalogeromitros D, Theoharides TC.  2012. Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells. J Invest Dermatol. 132: 324-329. Abstract in PubMed

Zhang B, Alysandratos KD, Angelidou A, Asadi S, Sismanopoulos N, Delivanis DA, Weng Z, Miniati A, Vasiadi M, Katsarou-Katsari A, Miao B, Leeman SE, Kalogeromitros D, Theoharides TC. 2011. Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis. J Allergy Clin Immunol. 127: 1522-1531. Abstract in PubMed

Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D. 2012. Mast cell activation and autism. Biochim Biophys Acta. 1822: 34-41. Abstract in PubMed

Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. 2012. Mast cells and inflammation. Biochim Biophys Acta. 1822: 21-33.. Abstract in PubMed

Zhang B, Angelidou A, Alysandratos KD, Vasiadi M, Francis K, Asadi S, Theoharides A, Sideri K, Lykouras L, Kalogeromitros D, Theoharides TC. 2010. Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children. J Neuroinflammation 7: 80.  Abstract in PubMed

Kempuraj D, Conti P, Vasiadi M, Alysandratos KD, Tagen M, Kalogeromitros D, Kourelis T, Gregoriou S, Makris M, Stavrianeas NG, Theoharides TC. 2010. IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells. Eur J Dermatol. 20: 865-867. Abstract in PubMed

Castellani ML, Felaco P, Galzio RJ, Tripodi D, Toniato E, De Lutiis MA, Fulcheri M, Caraffa A, Antinolfi P, Tetè S, Felaco M, Conti F, Pandolfi F, Theoharides TC, Shaik-Dasthagirisaheb YB. 2010. IL-31 a Th2 cytokine involved in immunity and inflammation. Int J Immunopathol Pharmacol. 23: 709-713. Abstract in PubMed

Alysandratos KD, Angelidou A, Vasiadi M, Zhang B, Kalogeromitros D, Katsarou-Katsari A, Theoharides TC. 2010. Increased affected skin gene expression and serum levels of thymic stromal lymphopoietin in atopic dermatitis. Ann Allergy Asthma Immunol.105: 403-404. Abstract in PubMed

Rozniecki JJ, Sahagian GG, Kempuraj D, Tao K, Jocobson S, Zhang B, Theoharides TC. 2010. Brain metastases of mouse mammary adenocarcinoma is increased by acute stress. Brain Res. 1366: 204-210. Abstract in PubMed

Angelidou A, Francis K, Vasiadi M, Alysandratos KD, Zhang B, Theoharides A, Lykouras L, Sideri K, Kalogeromitros D, Theoharides TC. 2010. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflammation 7: 48. Abstract in PubMed

Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC. 2010. Luteolin and thiosalicylate inhibit HgCl2 and thimerosal-induced VEGF release from human mast cells. Int J Immunopathol Pharmacol. 23: 1015-1020. Abstract in PubMed

Boucher W, Kempuraj D, Michaelian M, Theoharides TC. 2010. Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor. BJU Int. 106: 1394-1399. Abstract in PubMed

Theoharides T, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos K-D, Kalogeromitros D, Asadi S, Stavrianeas N, Petersson E, Leeman S, Conti P. 2010.  IL-33 Augments SP-Induced VEGF Secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci USA 107: 4448-4453.  Abstract in PubMed

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