Recent Publications from the Tesco Lab

Research Publications Neuroscience


Yeates EF, Tesco G 2016. The endosomal-associated deubiquitinating enzyme USP8 regulates BACE1 ubiquitination and degradation. J Biol Chem. Epub ahead of print. Abstract in PubMed

Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G. 2016. Genetic deletion of the clathrin adaptor GGA3 reduces anxiety and alters GABAergic transmission. PLoS One 11: e0155799. Abstract in PubMed

Cantu D, Walker K, Andresen L, Taylor-Weiner A, Hampton D, Tesco G, Dulla CG. 2014. Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic control. Cereb Cortex 25: 2306-2320. Abstract in PubMed

Walker KR, Tesco G. 2013. Molecular mechanisms of cognitive dysfunction following traumatic brain injury. Front Aging Neurosci. 5: 29. books

Kang EL, Biscaro B, Piazza F, Tesco G. 2012. BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the di-leucine motif in the carboxyl terminus. J Biol Chem. 287: 42867-42880. books

Walker KR, Kang EL, Whalen MJ, Shen Y, Tesco G. 2012. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 32: 10423-10437. books

Kittelberger KA, Piazza F, Tesco G, Reijmers LG. 2012. Natural amyloid-beta oligomers acutely impair the formation of a contextual fear memory in mice. PLoS One. 7: e29940. books

Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM. 2012. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neurodegener Dis. 9: 187-198. books

Tesco, G. 2012. Autophagy: a common road to perdition in acute brain injuries and Alzheimer's disease. J Neurochem. 120: 475-476. books

Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ. 2011. Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 31: 351-361. books

Kang EL, Cameron AN, Piazza F, Walker KR, Tesco G. 2010. Ubiquitin regulates GGA3-mediated degradation of BACE1. J Biol Chem. 285: 24108-24119. books

Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, del Monte F. 2010. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation 121: 1216-1226. books

Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. 2009. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity. Hum Mol Genet. 18: 3987-3996. books

Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W. 2009. Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cell Signal. 21: 567-576. books

Tesco G. 2007. New advances in Alzheimer's disease: from biology to therapy. Curr Genomics 8:484-485. books

Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. 2007. Depletion of GGA3 stabilizes BACE and enhances β-secretase activity. Neuron 54: 721-737. books

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