Recent Publications from the Taylor Lab

Research Publications Biochemistry Cell Biology Pharmacology


Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A. 2017. Proc Natl Acad Sci USA Epub ahead of print.  books

Chiu CJ, Chang ML, Li T, Gensler G, Taylor A. 2017. Visualization of dietary patterns and their associations with age-related macular degeneration. Invest Ophthalmol Vis Sci. 58: 1404-1410. books

Chiu CJ, Chang ML, Taylor A. 2016. Associations between periodontal microbiota and death rates. Sci Rep. 6:35428. books

Rowan S, Chang ML, Reznikov N, Taylor A. 2016. Disassembly of the lens fiber cell nucleus to create a clear lens: the p27 descent. Exp Eye Res. pii: S0014-4835(16)30028-8. books

Lyu L, Whitcomb EA, Jiang S, Chang ML, Gu Y, Duncan MK, Cvekl A, Wang WL, Limi S, Reneker LW, Shang F, Du L, Taylor A. 2015. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation leading to cataract. FASEB J 30: 1087-1095. books

Rowan S, Taylor A. 2015. Gene-diet interactions in age-related macular degeneration. Adv Exp Biol. 854: 95-101. books

Whitcomb EA, Chiu CJ, Taylor A 2015. Dietary glycemia as a determinant of health and longevity. Mol Aspects Med. 46: 14-20.  books

Liu K, Lyu L, Chin D, Gao J, Sun X, Shang F, Caceres A, Chang ML, Rowan S, Peng J, Mathias R, Kasahara H, Jian S, Taylor A. 2015. Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract. Proc Natl Acad. Sci USA 112: 1071-1076.  books

Chaffee BR, Shang F, Chang ML, Clement TM, Eddy EM, Wagner BD, Nakahara M, Nagata S, Robinson ML, Taylor A. 2014. Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development 141: 3388-3398. books

Chiu CJ, Chang ML, Zhang FF, Li T, Gensler G, Schleicher M, Taylor A. 2014. The relationship of major American dietary patterns to age-related macular degeneration. Am J Ophthalmol. 158: 118-127. books

Liu Z, Qin T, Zhou J, Taylor A, Sparrow JR, Shang F. 2014. Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes. Adv Exp Med Biol. 801: 237-250. books

Chang ML, Chiu CJ, Shang F, Taylor A. 2014. High glucose activates ChREBP-mediated HIF-1α and VEGF sxpression in human RPE cells under normoxia. Adv Exp Med Biol. 801: 609-621. books

Rowan S, Weikel KA, Chang ML, Nagel BA, Thinschmidt J, Carey AN, Grant MB, Fliesler SJ, Smith D, Taylor A. 2014. Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. Invest Ophthalmol Vis Sci. 55: 492-501. books

Whitcomb EA, Shang F, Taylor A. 2013. Common cell biologic and biochemical changes in aging and age-related diseases of the eye: toward new therapeutic approaches to age-related ocular diseases. Invest Ophthalmol Vis Sci. 54: ORSF31-36. books

Weikel KA, Garber C, Baburins A, Taylor A. 2013. Nutritional modulation of cataract. Nutr Rev. 72: 30-47. books

Schleicher M, Weikel K, Garber C, Taylor A. 2013. Diminishing risk for age-related macular degeneration with nutrition: a current view. Nutrients 5:2405-2456.  books

Liu Z, Taylor A, Liu Y, Wu M, Gong X, Shang F. 2012. Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin. Invest Ophthalmol Vis Sci. 53: 6655-6665. books

Taylor A. 2012. Mechanistically linking age-related diseases and dietary carbohydrate via autophagy and the ubiquitin proteolytic systems. Autophagy 8: 1404-1406. books

Bian Q, Gao S, Zhou J, Qin J, Taylor A, Johnson EJ, Tang G, Sparrow JR, Gierhart D, Shang F.  2012. Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med. 53: 1298-1307. books

Weikel KA, Chiu CJ, Taylor A.  2012. Nutritional modulation of age-related macular degeneration. Mol Aspects Med. 33: 318-375. books

Wu M, Zhang X, Bian Q, Taylor A, Liang JJ, Ding L, Horwitz J, Shang F.  2012. Oligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin. Invest Ophthalmol Vis Sci. 53: 2541-2550. books

Uchiki T, Weikel KA, Jiao W, Shang F, Caceres A, Pawlak D, Handa JT, Brownlee M, Nagaraj R, Taylor A. 2012. Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics). Aging Cell 11: 1-13. books

Weikel KA, Fitzgerald P, Shang F, Caceres MA, Bian Q, Handa JT, Stitt AW, Taylor A. 2012. Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets. Invest Ophthalmol Vis Sci. 53: 622-632. books

Shang F, Taylor A. 2011. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Rad Biol Med. 51: 5-16. books

Chiu CJ, Conley YP, Gorin MB, Gensler G, Lai CQ, Shang F, Taylor A. 2011. Associations between Genetic Polymorphisms of Insulin-like Growth Factor Axis Genes and Risk for Age-Related Macular Degeneration.. Invest Ophthalmol Vis Sci. 52: 9099-1907. books

Chiu C-J, Taylor A. 2011. Dietary hyperglycemia, glycemic index and age-related metabolic retinal diseases. Prog Ret Eye Res. 30: 18-53. books

Chiu C-J, Liu S, Willett WC, Wolever, TMS, Brand-Miller JC, Barclay AC, Taylor A. 2011.  Informing food choices and health outcomes by use of the dietary glycemic index. Nutr Rev. 69: 231-242. books

Caceres A, Shang F, Wawrousek E, Liu Q, Avidan O, Cvekl A, Yang Y, Haririnia A, Storaska A, Fushman D, Kuszak J, Dudek E, Smith D, Taylor A.  2010. Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in vivo. PLoS ONE 5: e13331. books

Chiu CJ, Robman L, McCarty CA, Mukesh BN, Taylor HR, Taylor A. 2010. Dietary carbohydrate in relation to cortical and nuclear lens opacities in the Melbourne Visual Impairment Project. Invest Ophthalmol Vis Sci. 51: 2897-2905. books

Dudek EJ, Lampi KJ, Lampi J, Shang F, King J, Wang Y,Taylor A. 2010. Ubiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidation. Invest Ophthalmol Vis Sci. 51: 4164-4173. books

Whitcomb EA, Taylor A. 2009. Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7 Cell Division  4: 17. books

Fernandes AF, Bian Q, Taylor A, Pereira P and Shang F. 2009. Proteasome inactivation promotes p38 MAPK-dependent PI3K activation and increases IL-8 production in retinal pigment epithelial cells. Mol Biol Cell. 20: 3690-3699 books

Chiu CJ, Milton RC, Klein R, Gensler G, Taylor A. 2009. Dietary compound score and risk of age-related macular degeneration in the Age-Related Eye Disease Study. Ophthalmology 116: 939-946. books

Chiu CJ, Klein R, Milton RC, Gensler G, Taylor A. 2009. Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements? Br J Ophthalmol. 93: 1241-1246. books

Whitcomb EA, Dudek EJ, Liu Q, Taylor A. 2009. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. Mol Cell Biol. 20: 1-9. books

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