Recent Publications from the Stadecker Lab

Research Publications Immunology


Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ. 2018. CD209a synergizes with Dectin-2 and mincle to drive severe Th17 cell-mediated schistosome egg-induced immunopathology. Cell Rep. 22: 1288-1300. Abstract in PubMed

Smith PM, Sproule TJ, Philip VM, Roopenian DC, Stadecker MJ. 2015. Minor genomic differences between related B6 and B10 mice affect severity of schistosome infection by governing the mode of dendritic cell activation. Eur J Immunol. 45: 2312-2323. Abstract in PubMed

Ponichtera HE, Stadecker MJ. 2015. Dendritic cell expression of the c-type lectin receptor CD209a: a novel innate parasite-sensing mechanism inducing Th17 cells that drive severe immunopathology in murine schistosome infection. Exp Parasitol. 158: 42-47. Abstract in PubMed

Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, Salantes DB, Lai CQ, Parnell LD, Yun TJ, Cheong C, Bunnell SC, Hacohen N, Stadecker MJ. 2014. CD209a expression on dendritic cells Is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J Immunol. 192: 4655-4665. Abstract in PubMed

Liberman R, Bond S, Shainheit MG, Stadecker MJ, Forgac M. 2013. Regulated assembly of the V-ATPase is increased during cluster disruption-induced maturation of dendritic cells through a PI-3 Kinase/mTOR-dependent pathway. J Biol Chem. 289: 1355-1363. Abstract in PubMed

Mbow M, Larkin BM, Meurs L, Wammes LJ, de Jong SE, Labuda LA, Camara M, Smits HH, Polman K, Dieye TN, Mboup S, Stadecker MJ, Yazdanbakhsh M. 2013. T-helper 17 cells are associated with pathology in human schistosomiasis. J Infect Dis. 207: 186-195. books

Deleon D, Paniz Mondolfi AE, Stadecker MJ, Lizzul P. 2013. Annular erythematous plaques in a patient with asthma. Clin Exp Dermatol. 38: 102-104. books

Stadecker, MJ. 2012. The gamut of host immune responses and immunopathology in parasitic diseases caused by protozoa and helminths: human perspective and experimental models. Semin Immunopathol. 34: 733-734. books

Larkin BM, Smith PM, Ponichtera HE, Shainheit MG, Rutitzky LI, Stadecker MJ. 2012. Induction and regulation of pathogenic Th17 cell responses in schistosomiasis. Semin Immunopathol. 34: 873-888. books

Kosinski KC, Adjei MN, Bosompem KM, Crocker JJ, Durant JL, Osabutey D, Plummer JD, Stadecker MJ, Wagner AD, Woodin M, Gute DM. 2012. Effective control of Schistosoma haematobium infection in a Ghanaian community following installation of a water recreation area. PLoS Negl Trop Dis. 6: e1709. books

Koch LH, Layton CJ, Pilichowska M, Stadecker MJ, Barak O. 2011. Paraneoplastic pemphigus and Castleman's Disease in the setting of herpes simplex virus infection. Pediatr Dermatol. 29: 629-632. books

Shainheit MG, Lasocki KW, Finger E, Larkin BM, Smith PM, Sharpe AH, Dinarello CA, Rutitzky LI, Stadecker MJ. 2011. The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β. J Immunol. 187: 5328-5335. books

Smith PM, Jacque B, Conner JR, Poltorak A, Stadecker MJ. 2011. IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection. PLoS Pathog. 7: e1002272. books

Rutitzky LI, Stadecker MJ. 2011. Exacerbated egg-induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL-17 and restrained by IFN-γ. Eur J Immunol. 41: 2677-2687. books

Kosinski KC, Bosompem KM, Stadecker MJ, Wagner AD, Plummer J, Durant JL, Gute DM. 2011. Diagnostic accuracy of urine filtration and dipstick tests for Schistosoma haematobium infection in a lightly infected population of Ghanaian schoolchildren. Acta Trop. 118: 123-127. books

Rutitzky LI, Smith PM, Stadecker MJ. 2009. T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation. Eur J Immunol 39: 2470-2481. books

Smith PM, Shainheit MG, Bazzone LE, Rutitzky LI, Poltorak A, Stadecker MJ. 2009. Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis. J Immunol 183: 3317-3323. books

Shainheit MG, Smith PM, Bazzone LE, Wang AC, Rutitzky LI, Stadecker MJ. 2008. Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology. J Immunol 181: 8559-8566. books

Bazzone LE, Smith PM, Rutitzky LI, Shainheit MG, Urban JF, Setiawan T, Blum AM, Weinstock JV, Stadecker MJ. 2008. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis. Infect Immun 76: 5164-5172. books

Elliott DE, Metwali A, Leung J, Setiawan T, Blum AM, Ince MN, Bazzone LE, Stadecker MJ, Urban JF Jr, and Weinstock JV. 2008. Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. J Immunol 181: 2414-2419. books

Rutitzky LI, Bazzone L, Shainheit MG, Joyce-Shaikh B, Cua DJ, Stadecker MJ. 2008. IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17. J Immunol 180, 2486-2495. books

Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ,Gause WC. 2007. Protective immune mechanisms in helminth infection. Nat Rev Immunol 7: 975-987. books

Cass CL, Johnson JR, Califf LL, Xu T, Hernandez HJ, Stadecker MJ, Yates JR 3rd, Williams DL. 2007. Proteomic analysis of Schistosoma mansoni egg secretions. Mol Biochem Parasitol 155: 84-93. books

Shainheit MG, Saraceno R, Bazzone LE, Rutitzky LI, Stadecker MJ. 2007. Disruption of interleukin-27 signaling results in impaired gamma interferon production but does not significantly affect immunopathology in murine schistosome infection. Infect Immun 75: 3167-3177. books

Rutitzky LI, Stadecker MJ. 2006. CD4 T cells producing pro-inflammatory interleukin-17 mediate high pathology in schistosomiasis. Mem Inst Oswaldo Cruz 101 Suppl 1:327-30. books

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