Recent Publications from the Sonenshein Lab

Research Publications Microbiology


Levdikov VM, Blagova EV, Young VL, Belitsky BR, Lebedev A, Sonenshein AL, Wilkinson AJ. 2016. Structure of the branched chain amino acid and GTP sensing global regulator, CodY, from Bacillus subtilis. J Biol Chem. Epub ahead of print.  Abstract in PubMed

Barbieri G, Albertini AM, Ferrari E, Sonenshein AL, Belitsky BR. 2016. Interplay of CodY and ScoC in the regulation of major extracellular protease genes of Bacillus subtilis. J Bacteriol. 198: 907-920.  Abstract in PubMed

Belitsky BR, Brinsmade SR, Sonenshein AL 2015. Intermediate levels of Bacillus subtilis CodY activity are required for derepression of the branched-chain amino acid permease, BraB. PLoS Genet. 11: e1005600. Abstract in PubMed

Richardson AR, Somerville GA, Sonenshein AL. 2015. Regulating the intersection of metabolism and pathogenesis in gram-positive bacteria. Microbiol Spectr. 3.  Abstract in PubMed

Sand A, Holwerda EK, Ruppertsberger NM, Maloney M, Olson DG, Nataf Y, Borovok I, Sonenshein AL, Bayer EA, Lamed R, Lynd LR, Shoham Y. 2015. Three cellulosomal xylanase genes in C. thermocellum are regulated by both vegetative SigA (σA) and alternative SigI6 (σI6) factors. FEBS Letts. 589(20 Pt B): 3133-3140.  Abstract in PubMed

Belitsky BR, Barbieri G, Albertini AM, Ferrari E, Strauch MA, Sonenshein AL. 2015. Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC. Mol Micrbiol. 97: 698-716. Abstract in PubMed

Bouillaut L, McBride S, Sorg JA, Schmidt DJ, Suarez JM, Tzipori S, Mascio C, Chesnel L, Sonenshein AL. 2015. Effects of surotomycin on Clostridium difficile viability and tPLosoxin production in vitro. Antimicrob Agents Chemother. 59: 4199-4205. Abstract in PubMed

Barbieri G, Voigt B, Albrecht D, Hecker M, Albertini AM, Sonenshein AL, Ferrari E, Belitsky BR. 2015. CodY regulates expression of the Bacillus subtilis extracellular proteases Vpr and Mpr. J Bacteriol. Epub ahead of print. 197: 1423-1432. Abstract in PubMed

Bouillaut L, Dubois T, Sonenshein AL, Dupuy B. 2014. Integration of metabolism and virulence in Clostridium difficile. Res Microbiol. 166: 375-383. Abstract in PubMed

Lobel L, Sigal N, Borovok I, Belitsky BR, Sonenshein AL, Herskovits AA. 2015. The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA. Mol Microbiol. 95: 624-644. Abstract in PubMed

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL. 2014. Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY. Proc Natl Acad Sci USA 111: 8227-8232. Abstract in PubMed

Roux A, Todd DA, Velázquez JV, Cech NB, Sonenshein AL. 2014. CodY-mediated regulation of the Staphylococcus aureus Agr system integrates nutritional and population density signals. J Bacteriol. 196: 1184-1196. Abstract in PubMed

Shulami S, Shenker O, Langut Y, Lavid N, Gat O, Zaide G, Zehavi A, Sonenshein AL, Shoham Y. 2014. Multiple regulatory mechanisms control the expression of the Geobacillus stearothermophilus gene for extracellular xylanase. J Biol Chem. 289: 25957-25975. Abstract in PubMed

Mooyottu S, Kollanoor-Johny A, Flock G, Bouillaut L, Upadhyay A, Sonenshein AL, Venkitanarayanan K. 2014. Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro. Int J Mol lSic. 15: 4415-4430. Abstract in PubMed

Belitsky BR, Sonenshein AL. 2013. Genome-wide identification of Bacillus subtilis CodY-binding sites at single-nucleotide resolution. Proc Natl Acad Sci USA 110: 7264-7273. Abstract in PubMed

Pechter KB, Meyer FM, Serio AW, Stülke J, Sonenshein AL. 2013. Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis. J Bacteriol. 195: 1525-1537. Abstract in PubMed

Château A, van Schaik W, Joseph P, Handke LD, McBride SM, Smeets FM, Sonenshein AL, Fouet A. 2013. Identification of CodY-targets in Bacillus anthracis by genome-wide in vitro binding analysis. J Bacteriol. 195: 1204-1213. Abstract in PubMed

Mittal M, Pechter KB, Picossi S, Kim HJ, Kerstein KO, Sonenshein AL. 2013. Dual role of CcpC protein in regulation of aconitase gene expression in Listeria monocytogenes and Bacillus subtilis. Microbiology 159 (Pt 1): 68-76. Abstract in PubMed

Bouillaut L, Self WT, Sonenshein AL. 2013. Proline-dependent regulation of Clostridium difficile stickland metabolism. J Bacteriol. 195: 844-854. Abstract in PubMed

Babakhani F, Bouillaut L, Sears P, Sims C, Gomez A, Sonenshein AL. 2013. Fidaxomicin inhibits toxin production in Clostridium difficile. J Antimicrob Chemother. 68: 515-522. Abstract in PubMed

Liu H, Bouillaut L, Sonenshein AL, Melville SB. 2012. Use of a mariner-based transposon mutagenesis system to isolate Clostridium perfringens mutants deficient in gliding motility. J Bacteriol. 195: 629-636. Abstract in PubMed

Babakhani F, Bouillaut L, Gomez A, Sears P, Nguyen L, Sonenshein AL. 2012. Fidaxomicin inhibits spore production in Clostridium difficile. Clin Infect Dis. 55 Suppl 2: S162-169. Abstract in PubMed

Montgomery CP, Boyle-Vavra S, Roux A, Ebine K, Sonenshein AL, Daum RS. 2012. CodY deletion enhances in vivo virulence of community-associated methicillin-resistant Staphylococcus aureus clone USA300. Infect Immun. 80: 2382-2389. Abstract in PubMed

Moses S, Sinner T, Zaprasis A, Stöveken N, Hoffmann T, Belitsky BR, Sonenshein AL, Bremer E. 2012. Proline utilization by Bacillus subtilis: uptake and catabolism. J Bacteriol. 194: 745-758. Abstract in PubMed

Belitsky BR, Sonenshein AL. 2011. CodY-mediated regulation of guanosine uptake in Bacillus subtilis. J Bacteriol. 193: 6276-6287. Abstract in PubMed

Brinsmade SR, Sonenshein AL. 2011. Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides. J Bacteriol. 193: 5637-5648. Abstract in PubMed

Belitsky BR, Sonenshein AL. 2011. Roadblock repression of transcription by Bacillus subtilis CodY. J Mol Biol. 411: 729-743. Abstract in PubMed

Amuguni JH, Lee S, Kerstein KO, Brown DW, Belitsky BR, Herrmann JE, Keusch GT, Sonenshein AL, Tzipori S. 2011. Sublingually administered Bacillus subtilis cells expressing tetanus toxin C fragment induce protective systemic and mucosal antibodies against tetanus toxin in mice. Vaccine. 29: 4778-4784. Abstract in PubMed

McBride SM, Sonenshein AL. 2011. The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile.  Microbiology. 157: 1457-1465. Abstract in PubMed

Belitsky BR, Sonenshein AL. 2011. Contributions of multiple binding sites and effector-independent binding to CodY-mediated regulation in Bacillus subtilis. J Bacteriol. 193: 473-484. Abstract in PubMed

McBride SM, Sonenshein AL 2011. Identification of a genetic locus responsible for antimicrobial peptide resistance in Clostridium difficile. Infect Immun. 79: 167-176. Abstract in PubMed

Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL. 2010. Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools. J Bacteriol. 192: 6357-6368. Abstract in PubMed

Lee S, Belitsky BR, Brinker JP, Kerstein KO, Brown DW, Clements JD, Keusch GT, Tzipori S, Sonenshein AL, Herrmann JE. 2010. Development of a Bacillus subtilis-based rotavirus vaccine. Clin Vaccine Immunol.  17: 1647-1655. Abstract in PubMed

Dineen SS, McBride SM, Sonenshein AL. 2010. Integration of metabolism and virulence by Clostridium difficile CodY. J Bacteriol. 192: 5350-5362. Abstract in PubMed

Lee S, Belitsky BR, Brown DW, Brinker JP, Kerstein KO, Herrmann JE, Keusch GT, Sonenshein AL, Tzipori S. 2010. Efficacy, heat stability and safety of intranasally administered Bacillus subtilis spore or vegetative cell vaccines expressing tetanus toxin fragment C. Vaccine 28: 6658-6665. Abstract in PubMed

Sorg JA, Sonenshein AL. 2010. Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J Bacteriol. 192: 4983-4990. Abstract in PubMed

Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, Somerville GA, Bodi K, Sonenshein AL. 2010. Direct targets of CodY in Staphylococcus aureus. J Bacteriol. 192: 2861-2877. books

Giel JL, Sorg JA, Sonenshein AL, Zhu J. 2010. Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One 15: e8740. books

Villapakkam AC, Handke LD, Belitsky BR, Levdikov VM, Wilkinson AJ, Sonenshein AL. 2009. Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids. J Bacteriol. 191: 6865-6876. books

van Schaik W, Château A, Dillies MA, Coppée JY, Sonenshein AL, Fouet A. 2009. The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence. Infect Immun. 77: 4437-45. Abstract in PubMed

Levdikov VM, Blagova E, Colledge VL, Lebedev AA, Williamson DC, Sonenshein AL, Wilkinson AJ. 2009. Structural rearrangement accompanying ligand binding in the GAF domain of CodY from Bacillus subtilis. 2009. J Mol Biol.  390: 1007-1018. Abstract in PubMed

Sorg JA, Sonenshein AL. 2009. Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol. 191: 1115-1117. Abstract in PubMed

Mittal M, Picossi S, Sonenshein AL 2009. CcpC-dependent regulation of citrate synthase gene expression in Listeria monocytogenes. 2009. J Bacteriol. 191: 862-872. Abstract in PubMed

Sorg JA, Sonenshein AL. 2008. Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol. 190: 2505-2512. Abstract in PubMed

Majerczyk CD, Sadykov MR, Luong TT, Lee C, Somerville GA, Sonenshein AL. 2008. Staphylococcus aureus CodY negatively regulates virulence gene expression.J Bacteriol. 190: 2257-2265. Abstract in PubMed

Belitsky BR, Sonenshein AL. 2008. Genetic and biochemical analysis of CodY-binding sites in Bacillus subtilis. J Bacteriol. 190: 1224-1236. Abstract in PubMed

Handke LD, Shivers RP, Sonenshein AL. 2008. Interaction of Bacillus subtilis CodY with GTP. J Bacteriol. 190: 798-806. Abstract in PubMed

Dineen SS, Villapakkam AC, Nordman JT, Sonenshein AL. 2007. Repression of Clostridium difficile toxin gene expression by CodY. Mol Microbiol. 66: 206-219. Abstract in PubMed

Picossi S, Belitsky BR, Sonenshein AL. 2007. Molecular mechanism of the regulation of Bacillus subtilis gltAB expression by GltC. J Mol Biol. 365: 1298-1313. Abstract in PubMed

Bennett HJ, Pearce DM, Glenn S, Taylor CM, Kuhn M, Sonenshein AL, Andrew PW, Roberts IS. 2007. Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence. Mol Microbiol. 63: 1453-1467. Abstract in PubMed

Sonenshein AL. 2007. Control of key metabolic intersections in Bacillus subtilis. Nat Rev Microbiol. 5: 917-927. Abstract in PubMed

Shivers RP, Dineen SS, Sonenshein AL. 2006. Positive regulation of Bacillus subtilis ackA by CodY and CcpA: establishing a potential hierarchy in carbon flow. Mol Microbiol. 62: 811-822. Abstract in PubMed

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