Recent Publications from the Shen Lab

Research Publications Microbiology

 

Ribis JW, Ravichandran P, Putnam EE, Pishdadian K, Shen A. 2017. The conserved spore coat protein SpoVM Is largely dispensable in Clostridium difficile spore formation. mSphere eCollection 2017. Sept - Oct. books

Donnelly ML, Li W, Li YQ, Hinkel L, Setlow P, Shen A. 2017. A Clostridium difficile-specific, gel-forming protein required for optimal spore germination.MBio 8: e02085-16. books

Gibbs KA, Shen A. 2016. Editorial: Signals to sociality: how microbial communication fashions communities. FEMS Microbiol Rev. Epub ahead of print.  books

Donnelly ML, Fimlaid KA, Shen A. 2016. Characterization of Clostridium difficile spores lacking either SpoVAC or dipicolinic acid synthetase. J Bacteriol. 198: 1694-1707.  books

Kevorkian Y, Shirley DJ, Shen A. 2016. Regulation of Clostridium difficile spore germination by the CspA pseudoprotease domain. Biochime 122: 243-254.  books

Fimlaid KA, Jensen O, Donnelly ML, Francis MB, Sorg JA, Shen A. 2015. Identification of a novel lipoprotein regulator of Clostridium difficile spore germination. PLoS Pathog. 11: e1005239. books

Shen A. 2015. A gut odyssey: The impact of the microbiota on Clostridium difficile spore formation and germination. PLoS Pathog. 11: e1005157. books

Fimlaid KA, Jensen O, Donnelly ML, Siegrist MS, Shen A. 2015. Regulation of Clostridium difficile spore formation by the SpoIIQ and SpoIIIA proteins. PLoS Genet. 11: e1005562. books

Bender KO, Garland M, Ferreyra JA, Hryckowian AJ, Child MA, Puri AW, Solow-Cordero DE, Higginbottom SK, Segal E, Banaei N, Shen A, Sonnenburg JL, Bogyo M. 2015. A small-molecule antivirulence agent for treating Clostridium difficile infection. Sci Transl Med. 7: 306ra148. books

Wang S, Shen A, Setlow P, Li YQ. 2015. Characterization of the dynamic germination of individual Clostridium difficile spores using Raman spectroscopy and differential interference contrast microscopy. J Bacteriol. 197: 2361-2373. books

Fimlaid KA, Shen A. 2015. Diverse mechanisms regulate sporulation sigma factor activity in the Firmicutes. Curr Opin Microbiol. 24: 88-95. books

Pishdadian K, Fimlaid KA, Shen A. 2015. SpoIIID-mediated regulation of σK function during Clostridium difficile sporulation. Mol Microbiol. 95: 189-208. books

Shen A. 2014. Simplified protein purification using an autoprocessing, inducible enzyme tag. Methods Mol Biol. 1177: 59-70.  books

Paredes-Sabja D, Shen A, Sorg JA. 2014. Clostridium difficile spore biology: sporulation, germination, and spore structural proteins. Trends Microbiol. 22: 406-416 books

Fimlaid KA, Bond JP, Schutz KC, Putnam EE, Leung JM, Lawley TD, Shen A. 2013. Global analysis of the sporulation pathway of Clostridium difficile. PLoS Genet. 9: e1003660. books

Adams CM, Eckenroth BE, Putnam EE, Doublié S, Shen A. 2013. Structural and functional analysis of the CspB protease required for Clostridium spore germination. PLoS Pathog. 9: e1003165. books

Putnam EE, Nock AM, Lawley TD, Shen A. 2013. SpoIVA and SipL are Clostridium difficile spore morphogenetic proteins. J Bacteriol. 195: 1214-1225.  books

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