Recent Publications from the Schaffhausen Lab

Research Publications Cell Biology Genetics Microbiology


Denis D, Rouleau C, Schaffhausen BS. 2016. A transformation-defective polyomavirus middle T antigen with a novel defect in PI3 kinase signaling. J Virol. Epub ahead of print. Abstract in PubMed

Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. 2016. Transformation by Polyomavirus middle T antigen involve a unique bimodal interaction with the Hippo effector YAP. J Virol. 90: 7032-7045. Abstract in PubMed

White EA, Kramer RE, Hwang JH, Pores Fernando AT, Nana N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM. 2014. Papillomavirus E7 oncoproteins share functions with Polyomavirus small T antigens. J Virol. 89: 2857-2865. Abstract in PubMed

Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. 2014. Polyoma small T antigen interacts with YES-Associated Protein (YAP) to regulate cell survival and differentiation. J Virol. 88: 12055-12064. Abstract in PubMed  (Correction: J Virol. 89: 6971)  Abstract in PubMed

Utermark T, Schmit F, Lee SH, Gao X, Schaffhausen BS, Roberts TM. 2014. The PI3K isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type. J Virol. 88: 10673-10679. books

Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM. 2014. Polyoma small T antigen triggers cell death via mitotic catastrophe. Oncogene 34: 2483-2492. books

Banerjee P, Dejesus R, Gjoerup O, Schaffhausen BS. 2013. Viral Interference with DNA Repair by Targeting of the Single-Stranded DNA Binding Protein RPA. PLoS Pathog. 9: e1003725. books

Harrison C, Jiang T, Banerjee P, Meinke G, D'Abramo CM, Schaffhausen B, Bohm A. 2013. Polyomavirus large T-antigen binds symmetrical repeats at the viral origin in an asymmetrical manner. J Virol. 87: 13751-13759. books

Hwang JH, Jiang T, Kulkarni S, Faure N, Schaffhausen BS. 2013. Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt. J Biol Chem. 288: 32064-32073. books

Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A. 2012. Inhibition of cell migration by PITENINs: the role of ARF6. Oncogene 31: 4317-4332. books

Andrabi S, Hwang JH, Choe JK, Roberts TM, Schaffhausen BS. 2011. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. J Virol. 85: 10649-10658. books

Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM. 2011. Transgenic expression of polyoma virus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol. 85: 5581-5592. books

Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. 2010. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci USA 107: 21026-21031. books

Fluck MM, Schaffhausen BS. 2009. Lessons in signaling and tumorigenesis from polyomavirus middle T antigen. Microbiol Mol Biol Rev. 73: 542-563. books

Knoblich K, Whittaker S, Ludwig C, Michiels P, Jiang T, Schaffhausen B, Günther U. 2009. Backbone assignment of the N-terminal polyomavirus large T antigen. Biomol NMR Assign. 3: 119-123. books

Cheng J, DeCaprio J, Fluck M,  Schaffhausen B. 2009. Cellular transformation by SV40 and murine polyoma virus T antigens. Semin Cancer Biol. 19: 218-228. books

Schaffhausen B, Roberts T. 2009. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology 384: 304-316. books

Gunther U, Schaffhausen B. 2009. Studying Protein Interactions by Line Shape Analysis. In: Ligand Binding and Ligand Screening by NMR. Istvan Pelczer, Ed, Oxford University Press, Oxford.

Schaffhausen B. 2008. Molecular Biology of Murine Polyomaviruses. In: Encyclopedia of Virology, 3rd Ed.  Mahay B, Van Regenmortel M, Eds., Elsevier, Oxford, pp 271-277.

Siwko SK, Bu W, Gutierrez C, Lewis B, Jechlinger M, Schaffhausen B, Li Y. 2008. Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.  Neoplasia 10: 653-662. books

Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS. 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. J Virol. 82: 4946-4954. books

Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B. 2007. Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci USA 104: 19011-19016. books

Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM.  2007. Surveillance mechanism linking Bub1 loss to the p53 pathway.  Proc Natl Acad Sci USA 104: 8334-8339. books

Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F.  2007. Essential role of PDK1 in regulating endothelial cell migration.  J Cell Biol. 176:1035-1047. books

Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ. 2007. The p110α isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 81:7069-7076. books

Mittag T, Franzoni L, Cavazzini D, Schaffhausen B, Rossi GL, Gunther UL. 2006. Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding. J Am Chem Soc. 128: 9844-9848. books

Love TM, de Jesus R, Kean JA, Sheng Q, Leger A, Schaffhausen BS. 2005. Activation of CREB/ATF sites by polyomavirus large T antigen. J Virol. 79: 4180-4190. books

Whalen KA, de Jesus R, Kean JA, Schaffhausen BS. 2005. Genetic analysis of the polyomavirus DnaJ domain. J Virol. 79:15, 9982-9990. books

Lu A, Zhang H, Zhang X, Wang H, Hu Q, Shen L, Schaffhausen B, Hou W, Li L. 2004. Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase. Virology 324: 84-89. books

Mittag T, Schaffhausen B, Gunther U. 2004. Tracing kinetic intermediates during ligand binding. J Am Chem Soc. 126: 9017-9023. books

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