Recent Publications from the Pothos Lab

Research Publications Neuroscience Pharmacology

 

Obici S, Magrisso IJ, Ghazarian AS, Shirazian A, Miller JR, Loyd CM, Begg DP, Krawczewski Carhuatanta KA, Haas MK, Davis JF, Woods SC, Sandoval DA, Seeley RJ, Goodyear LJ, Pothos EN, Mul JD. 2015. Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation. Mol Metab. 4: 692-705. books

Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. 2015. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc Natl Acad Sci USA 112: 3463-3468. books

Pothos EN. 2012.The first Tufts University seminar on the obesity epidemic: science and food economics. Physiol Behav. 107: 125. books

Allen PJ, Batra P, Geiger BM, Wommack T, Gilhooly C, Pothos EN. 2012. Rationale and consequences of reclassifying obesity as an addictive disorder: neurobiology, food environment and social policy perspectives. Physiol Behav. 107: 126-137. books

Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ. 2012. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 122: 507-518. books

Leinninger GM, Opland DM, Jo YH, Faouzi M, Christensen L, Cappellucci L8. A, Rhodes CJ, Gnegy ME, Becker JB, Pothos EN, Seasholtz AF, Thompson RC, Myers MG Jr. 2011. Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. 7: 313-323. books

Umberg EN, Pothos EN. 2011. Neurobiology of aversive states. Physiol Behavior 104: 69-75. books

Cordeira JW, Frank L, Sena-Esteves M, Pothos EN, Rios M. 2010. Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system. J Neurosci. 30: 2533-2541. books

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. 2009. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci USA. 106: 14622-14627.  books

Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J. 2009. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J Neurochem. 110: 613-621.  books

Geiger BM, Frank LE, Caldera-Siu AD, Pothos EN. 2008. Survivable stereotaxic surgery in rodents. J Vis Exp. pii: 880.  books

Frank LE, Caldera-Siu AD, Pothos EN. 2008. Primary dissociated midbrain dopamine cell cultures from rodent neonates. J Vis Exp. 21: 820.  books

Sinnayah P, Jobst EE, Rathner JA, Caldera-Siu AD, Tonelli-Lemos L, Eusterbrock AJ, Enriori PJ, Pothos EN, Grove KL, Cowley MA. 2008. Feeding induced by cannabinoids is mediated independently of the melanocortin system. PLoS One 3: e2202.  books

Geiger BM, Behr GG, Frank LE, Caldera-Siu AD, Beinfeld MC, Kokkotou EG, Pothos EN. 2008. Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB J. 22: 2740-2746.  books

Pissios P, Frank L, Kennedy AR, Porter DR, Marino FE, Liu FF, Pothos EN, Maratos-Flier E. 2008. Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice. Biol Psychiatry 64: 184-191.  books

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J. 2007. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci USA. 104: 11441-11446.  books

Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. 2006. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51: 811-822.  books

Zhong N, Kim CY, Rizzu P, Geula C, Porter DR, Pothos EN, Squitieri F, Heutink P, Xu J. 2006. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem. 281: 20940-20948.  books

Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. 2005. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-496.  books

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