Recent Publications from the Poltorak Lab

Research Publications Genetics Immunology Microbiology


Larkin B, Ilyukha V, Sorokin M, Buzdin A, Vannier E, Poltorak A. 2017. Cutting Edge: Activation of STING in T cells induces Type I IFN responses and cell death. J Immunol. Epub ahead of print. books

Surpris G, Poltorak A. 2016. The expanding regulatory network of STING-mediated signaling.  Curr Opin Microbiol. 32: 144-150. books

Najjar M*, Saleh D*, Zelic M, Nogusa S, Shah A, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis, Balachandran S, Kelliher M, Poltorak A, Degterev A. 2016. RIPK1 and RIPK3 kinases promote cell death-independent inflammation by TLR4-TRIF Immunity Epub ahead of print. * equal contribution. books

Poltorak A, Kurmyshkina O, Volkova T. 2016. Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine Growth Factor Rev. Epub ahead of print.  books

Ram DR, Ilyukha V, Volkova T, Buzdin A, Tai A, Smirnova I, Poltorak A. 2016. Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proc Natl Acad Sci USA 113: 1606-1611.  books

Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A. 2016. Cutting Edge: Novel Tmem173 allele reveals importance of STING N terminus in trafficking and type I IFN production. J Immunol. 196: 547-552.  books

Low D, DeGruttola AK, Poltrak A, Mizoguchi A, Mino-Kenudson M, Mizoguchi E. 2015. High endogenous expression of dhitinase 3-like 1 and excessive epithelial proliferation with colonic tumor formation in MOLF/EiJ mice. PLoS One 10: e0139149.  books

Schworer SA, Smirnova II, Kurbatova I, Bagina U, Churova M, Fowler T, Roy AL, Degterev A, Poltorak A. 2014. Toll-like receptor-mediated downregulation of the deubiquitinase CYLD protects macrophages from necroptosis in wild-derived mice. J Biol Chem. 289: 14422-14433. books

Moseman AP, Moseman EA, Schworer S, Smirnova I, Volkova T, von Andrian U, Poltorak A. 2013. Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. J Immunol. 191: 5615-5624. books

Smith PM, Jacque B, Conner JR, Poltorak A, Stadecker MJ. 2011. IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection. PLoS Pathog. 7: e1002272. books

Conner JR, Smirnova II, Moseman AP, Poltorak A. IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-κB p50. Proc Natl Acad Sci USA 107: 11477-11482. books

Smith PM, Shainheit MG, Bazzone LE, Rutitzky LI, Poltorak A, Stadecker MJ. 2009. Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis. J Immunol 183: 3317-3323. books

Conner JR, Smirnova II, Poltorak A. 2009. A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J Exp Med 206: 1615-1631. books

Losick VP, Stephan K, Smirnova II, Isberg RR, Poltorak A. 2009. A hemidominant Naip5 allele in MOLF/Ei-derived macrophages restricts L. pneumophila intracellular growth. Inf Immun 77: 196-204. books

Conner JR, Smirnova II, Poltorak A. 2008. Forward genetic analysis of toll-like receptor responses in wild-derived mice reveals a novel anti-inflammatory role for IRAK1BP1. J Exp Med 205: 305-314. books

Stephan K, Smirnova I, Jacque B, Poltorak A. 2007. Genetic analyses of the innate immune responses in wild-derived strains of mice. Eur J Immunol 37: 212-223. books

Jacque B, Stephan K, Smirnova I, Kim B, Gilling D, Poltorak A. 2006. Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality. Eur J Immunol 36: 1-10. books

Ehl S, Bischoff R, Ostler T, Vallbracht S, Schulte-Monting J, Poltorak A, Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34: 1146-1153. books

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