Recent Publications from the Moss Lab

Research Publications Neuroscience


Melón LC, Hooper A, Yang X, Moss SJ, Maguire J. 2017. Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology Epub ahead of print. books

Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, Holenz J, Duggan ME, Dunlop J, Mather RJ, Wang Q, Medina I, Brandon NJ, Deeb TZ, Moss SJ. 2017. The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity. Nat Med. 23: 1394-1396. books

Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A. 2017. Molecular architecture of potassium chloride co-transporter KCC2. Sci Rep. 7: 16452. books

Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ. 2017. Proc Natl Acad Sci USA 114: 11763-11768. books

Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker DJ, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ. 2017. N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. J Biol. Chem. Epub ahead of print. books

Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ. 2017. Seizing control of KCC2: A new therapeutic target for epilepsy. Trends Neurosci. Epub ahead of print.  books

Wobst HJ, Delsing L, Brandon NJ, Moss SJ. 2017. Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. PLoS one 12: e0177181.  books

Wobst HJ, Wesolowski SS, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, Deeb TZ, Dunlop J, Brandon NJ, Moss SJ. 2017. Cytoplasmic relocalization of TAR DNA-binding protein 43 is not sufficient to reproduce cellular pathologies associated with ALS In vitro. Front Mol Neurosci. Epub ahead of print.  books

Rifkin RA, Moss SJ, Slesinger PA. 2017. G protein-gated potassium channels: A link to drug addiction. Trends Pharmacol Sci. Epub ahead of print. books

Kang JY, Chadchankar J, Vien TN, Mighdoll MI, Hyde TM, Mather RJ, Deeb TZ, Pangalos MN, Brandon NJ, Dunlop J, Moss SJ. 2017. Deficits in the activity of presynaptic γ-Aminobutyric acid type B receptors contribute to altered neuronal excitability in Fragile X Syndrome. J Biol Chem. Epub ahead of print. books

Modgil A, Parakala ML, Ackley MA, Doherty JJ, Moss SJ, Davies PA. 2016. Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism. Neuropharmacology 113(Pt A):314-322.  books

Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA. 2016. Effects of Gabra2 point mutations on alcohol intake: Increased binge-like and blunted chronic drinking by mice. Alcohol Clin Exp Res. 40: 2445-2455. books

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL. 2016. Expandable and rapidly differentiating human induced neural stem cell lines for multiple tissue Engineering applications. Stem Cell Rep. Epub ahead of print. Abstract in PubMed

Vien TN, Moss SJ, Davies PA. 2016. Regulating the efficacy of inhibition through trafficking of γ-aminobutyric acid type A receptors. Anesth Analg. 123: 1220-1227. Abstract in PubMed

Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G. 2016. Genetic deletion of the clathrin adaptor GGA3 reduces anxiety and alters GABAergic transmission. PLoS One 11: e0155799. Abstract in PubMed

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ. 2016. Compromising KCC2 transporter activity enhances the development of continuous seizure activity. Neuropharmacology Epub ahead of print. books

Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ. 2016. Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR α2 subunit knock-in mouse. J Biol Chem. Epub ahead of print. books

Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA. 2016. A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons. J Neurosci. 36: 3106-3114. books

Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. 2016. Copper and protons directly activate the zinc-activated channel. Biochem Pharmacol. 103: 109-117. books

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. 2015. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci USA 112: 14805-14810. books

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. 2015. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices in vitro and in vivo. J Neurosci. 35: 8291-8286. books

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci USA  111: 3523-3528. books

Nakamura Y, Darnieder LM, Deeb TZ, Moss SJ. 2015. Regulation of GABAARs by phosphorylation. Adv Pharmacol. 72:97-146. books

Terunuma M, Haydon PG, Pangalos MN, Moss SJ. 2015. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Neuropharmacology 88: 74-81. books

Huyghe D, Nakamura Y, Terunuma M, Faideau M, Haydon P, Pangalos NM, Moss SJ. 2014. Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by G-aminobutyric type B receptors. J Biol Chem. 289: 28808-28815.  books

Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A. 2014. Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Nat Commun. 5: 3921. books

Comenencia-Ortiz E, Moss SJ, Davies PA. 2014. Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions. Psychopharmacology (Berl) 231: 3453-3465. books

Abramian AM, Comenencia-Ortiz E, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. 2014. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Sci USA 111: 7132-7137. books

Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U. 2014. Neural basis of benzodiazepine reward: Requirement for α2 containing GABAA receptors in the nucleus accumbens. Neuropsychopharmacology 39: 1805-1815. books

Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ. 2014. Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. J Neurosci. 34: 804-816. books

Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ. 2013. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABAA-receptor γ2 subunit. J Neurosci. 39: 15567-15577.

Hines RM, Hines DJ, Houston CM, Mukherjee J, Haydon PG, Tretter V, Smart TG, Moss SJ. 2013. Disrupting the clustering of GABAA receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficits. Proc Natl Acad Sci USA 110: 16628-16633. books

Nani F, Bright DP, Revilla-Sanchez R, Tretter V, Moss SJ, Smart TG. 2013. Tyrosine phosphorylation of GABAA receptor γ2-subunit regulates tonic and phasic inhibition in the thalamus. J Neurosci. 33: 12718-12727. books

Deeb TZ, Nakamura Y, Frost GD, Davies PA, Moss SJ. 2013. Disrupted Cl- homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. Eur J Neurosci. 38: 2453-2467. books

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA. 2013. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 33: 7264-7273. books

Hines DJ, Schmitt LI, Hines RM, Moss SJ, Haydon PG. 2013. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry 3: e212. books

Deeb TZ, Maguire J, Moss SJ. 2012. Possible alterations in GABA(A) receptor signaling that underlie benzodiazepine-resistant seizures. Epilepsia 53 Suppl 9: 79-88. books

Sukoff Rizzo SJ, Neal SJ, Hughes ZA, Beyna M, Rosenzweig-Lipson S, Moss SJ, Brandon NJ. 2012. Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes. Transl Psychiatry 2: e199. books

Gonzalez C, Moss SJ, Olsen RW. 2012. Ethanol promotes clathrin adaptor-mediated endocytosis via the intracellular domain of δ-containing GABAA receptors. J Neurosci. 32: 17874-17881. books

Jacob TC, Michels G, Silayeva L, Haydon J, Succol F, Moss SJ. 2012. Benzodiazepine treatment induces subtype-specific changes in GABAA receptor trafficking and decreases synaptic inhibition. Proc Natl Acad Sci USA 109: 18595-18600. books

Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA. 2012. Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors. Cell Rep. 2: 488-496. books

Oberlander JG, Porter DM, Onakomaiya MM, Penatti CA, Vithlani M, Moss SJ, Clark AS, Henderson LP. Estrous cycle variations in GABA(A) receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area. Neuroscience 226: 397-410. books

Tretter V, Mukherjee J, Maric HM, Schindelin H, Sieghart W, Moss SJ. 2012.Gephyrin, the enigmatic organizer at GABAergic synapses. Front Neurosci. 6: 23. books

Saliba RS, Kretschmannova K, Moss SJ. 2012. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. EMBO J. 31: 2937-29-51. books

Padgett CL, Lalive AL, Tan KR, Terunuma M, Munoz MB, Pangalos MN, Martínez-Hernández J, Watanabe M, Moss SJ, Luján R, Lüscher C, Slesinger PA. 2012. Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron 73: 879-889. books

Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. 2011. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J. Neurosci. 31: 18198-18210. books

Hines RM, Davies PA, Moss SJ, Maguire J.  2011. Functional regulation of GABA(A) receptors in nervous system pathologies. Curr Opin Neurobiol. 22: 552-558. books

Deeb TZ, Lee HH, Walker JA, Davies PA, Moss SJ.  2011. Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential. Channels (Austin). 5: 475-481. books

Hines RM, Davies PA, Moss SJ, Maguire J.  2011. Functional regulation of GABA(A) receptors in nervous system pathologies. Curr Opin Neurobiol. 22: 552-558. books

Mukherjee J, Kretschmannova K, Gouzer G, Maric HM, Ramsden S, Tretter V, Harvey K, Davies PA, Triller A, Schindelin H, Moss SJ. 2011. The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin. J Neurosci. 31: 14677-14687. books

Deng Q, Terunuma M, Fellin T, Moss SJ, Haydon PG. 2011. Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a Src kinase dependent pathway. Glia. 59: 1084-1093. books

Lee HH, Deeb TZ, Walker JA, Davies PA, Moss SJ. 2011. NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat Neurosci. 14: 736-743. books

Arancibia-Cárcamo IL, Fairfax BP, Moss SJ, Kittler JT. 2010. Studying the localization, surface stability and endocytosis of neurotransmitter receptors by antibody labeling and biotinylation approaches. in: The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology, Kittler, JT, Moss, SJ, eds, CRC Press, Boca Raton, FL, Chapter 6. books

Abramian AM, Comenencia-Ortiz E, Vithlani M, Tretter EV, Sieghart W, Davies PA, Moss SJ. 2010. Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. J Biol Chem. 285: 41795-41805. books

Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ. 2010. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry 16: 1006-1023. books

Terunuma M, Pangalos MN, Moss SJ. 2010. Functional modulation of GABAB receptors by protein kinases and receptor trafficking. Adv Pharmacol. 58: 113-122. books

Terunuma M, Vargas KJ, Wilkins ME, Ramírez OA, Jaureguiberry-Bravo M, Pangalos MN, Smart TG, Moss SJ, Couve A. 2010. Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. Proc Natl Acad Sci USA 107: 13918-13923. books

Lee HH, Jurd R, Moss SJ. 2010. Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci. 45: 173-179. books

Jurd R, Moss SJ. 2010. Impaired GABA(A) receptor endocytosis and its correlation to spatial memory deficits. Commun Integr Biol. 3: 176-178. books 

Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT. 2010. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Mol Cell Neurosci. 44: 330-341. books

Jurd R, Tretter V, Walker J, Brandon NJ, Moss SJ. 2010. Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Mol Cell Neurosci. 44: 129-133. books

Boyer SB, Clancy SM, Terunuma M, Revilla-Sanchez R, Thomas SM, Moss SJ, Slesinger PA. 2009. Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling. J Neurosci. 29: 15796-15809. books

Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart TG, Moss SJ. 2009. Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc Natl Acad Sci USA 106: 10039-10044. books

Arancibia-Cárcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Saliba RS, Smart TG, Yan Z, Kittler JT, Moss SJ. 2009. Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. Proc Natl Acad Sci USA 106: 17552-17557. books

Saliba RS, Gu Z, Yan Z, Moss SJ. 2009. Blocking L-type voltage-gated Ca2+ channels with dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and synaptic inhibition.  J Biol Chem. 284: 32544-32450.  books

Fellin T, Halassa MM, Terunuma M, Succol F, Takano H, Frank M, Moss SJ, Haydon PG. 2009. Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc Natl Acad Sci USA 106: 15037-15042. books

Mukherjee J, Kuryatov A, Moss SJ, Lindstrom JM, Anand R. 2009. Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors. J Neurochem. 110: 1885-1894. books

Jacob TC, Wan Q, Vithlani M, Saliba RS, Succol F, Pangalos MN, Moss SJ. 2009. GABA(A) receptor membrane trafficking regulates spine maturity. Proc Natl Acad Sci USA 106: 12500-12505. books

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research