Recent Publications from the Moore Lab

Research Publications Cell Biology Genetics Microbiology


McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM. 2017. A defective mRNA cleavage and polyadenylation complex facilitates expansions of transcribed (GAA)n repeats associated with Friedreich's Ataxia. Cell Rep. 20: 2490-2500.  books

Kuehner JN, Kaufman JW, Moore C. 2017. Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3'-end processing factors is a conserved DNA damage response in eukaryotes. DNA Repair 57:151-160. books

Costanzo M, Vander Sluis B, Koch E, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, et al, Moore C, Caudy A, Myers C, Andrews B & Boone C. 2016 The global yeast genetic interaction network: a hierarchical model of cell function and conserved principles of inheritance. Science 23;353(6306).  books

Blair L, Labitigan R, Liu Z, Zheng D, Pearson E, Nazeer F, Cao J, Rines R, Mackintosh S, Moore C, Li W, Tian B, Tackett A, Yan Q. 2016. KDM5 lysine demethylases are involved in maintenance of 3’ UTR length. Science Advances 2:e1501662. books

Yang F, Hsu P, Lee SD, Yang W, Xu W, Moore C, Varani G. 2016. The C-terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'- end processing. RNA Epub ahead of print.  books

Pearson E, Moore C. 2014. The evolutionarily conserved Pol II flap loop contributes to proper snoRNA transcription termination in yeast, Cell Reports 9:821-828. books<

Lee SD, Moore CL. 2014. Efficient mRNA polyadenylation requires a ubiquitin-like domain, a zinc knuckle, and a RING finger domain, all contained in the Mpe1 protein. Mol Cell Biol.34: 3955-3967. books

Pearson EL, Moore CL. 2013. Dismantling promoter-driven RNA polymerase II transcription complexes in vitro by the termination factor Rat1. J Biol Chem. 288: 19750-19759. books

Graber JH, Nazeer FI, Yeh PC, Kuehner JN, Borikar S, Hoskinson D, Moore CL. 2013. DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast. Genome Res. 23: 1690-1703. books

Barnwal RP, Lee SD, Moore C, Varani G. 2012. Structural and biochemical analysis of the assembly and function of the yeast pre-mRNA 3' end processing complex CF I. Proc Natl Acad Sci USA 109: 21342-21347. books

Schmid M, Poulsen MB, Olszewski P, Pelechano V, Saguez C, Gupta I, Steinmetz LM, Moore C, Jensen TH. 2012. Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins. Mol Cell 47: 267-280. books

Ghazy MA, Gordon JM, Lee SD, Singh BN, Bohm A, Hampsey M, Moore C. 2012. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Nucleic Acids Res. 40: 1214-1225. books

Gordon JM, Shikov S, Kuehner JN, Liriano M, Lee E, Stafford W, Poulsen MB, Harrison C, Moore C, Bohm A. 2011. Reconstitution of CF IA from overexpressed subunits reveals stoichiometry and provides insights into molecular topology. Biochemistry 50: 10203-10214. books

Ezeokonkwo C, Ghazy MA, Zhelkovsky A, Yeh PC, Moore C. 2012. Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae. FEBS Lett. 586: 1173-1178. books

Ezeokonkwo C, Zhelkovsky A, Lee R, Bohm A, Moore CL. 2011. A flexible linker region in Fip1 is needed for efficient mRNA polyadenylation. RNA 17: 652-664. books

Kuehner JN, Pearson EL, Moore C. 2011. Unravelling the means to an end: RNA polymerase II transcription termination. Nat Rev Mol Cell Biol. 12: 283-294. books

Leeper TC, Qu X, Lu C, Moore C, Varani G. 2010. Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1. J Mol Biol. 401: 334-349. books

Qu X, Lykke-Andersen S, Nasser T, Saguez C, Bertrand E, Jensen TH, Moore C. 2009. Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation. Mol Cell Biol. 29: 5327-2338. books

Krishnamurthy S, Ghazy MA, Moore C, Hampsey M. 2009. Functional interaction of the Ess1 prolyl isomerase with components of the RNA polymerase II initiation and termination machineries. Mol Cell Biol. 29: 2925-2934. books

Ghazy MA, He X, Singh BN, Hampsey M, Moore C. 2009. The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing. Mol Cell Biol. 29: 2296-2307. books

Dermody J, Dreyfuss J, Villén J, Ogundipe B, Gygi S, Park P, Ponticelli A, Moore C, Buratowski S, Bucheli M. 2008. Phosphorylation regulates novel stimulation of RNA polymerase II elongation by the SR-like protein Npl3. PLoS One 3: e3273. books

Saguez C, Schmid M, Olesen J, Ghazy M, Qu X, Poulsen M, Nasser T, Moore C, Jensen T. 2008. Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol Cell  31: 91-103. books

Meinke G, Ezeokokwo C, Balbo P, Moore C, Bohm A. 2008. Structure of yeast poly(A) polymerase in complex with the polymerase-binding domain of Fip1. Biochemistry 47: 6859-6869. books

Deka P, Bucheli M, Moore C, Buratowski S, Varani G. 2007. Structure of the yeast SR protein Npl3 and interaction with mRNA 3’-end processing signals. J Mol Biol. 375: 136-150. books

Qu X, Perez-Canadillas J-M, Agrawal S, De Baecke J, Cheng H, Varani G, Moore C. 2007. The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3’-end processing. J Biol Chem. 282: 2101-2115. books

Bucheli M, He H, Kaplan C, Moore C, Buratowski S. 2007. Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI. RNA 13: 1756-1764. books

Zhelkovsky A, Tacahashi Y, Nasser T, He X, Sterzer U, Jensen T, Domdey H, Moore, C. 2006.  The role of the Brr5/Ysh1 C-terminal domain and its homolog, Syc1, in mRNA 3’ end processing in Saccharomyces cerevisiae. RNA 12: 435-445. books

Kim M, Vasiljeva L, Rando O, Zhelkovsky A, Moore C, Buratowski S. 2006. Distinct mechanisms for snoRNA and mRNA termination. Mol Cell. 24: 723-734. books

He X, Moore C. 2005. Regulation of yeast mRNA 3' end processing by phosphorylation. Mol Cell. 19: 619-629. books 

Zhelkovsky A, Helmling S, Bohm A, Moore C. 2004. Mutations in the middle domain of yeast poly(A) polymerase affect interactions with RNA but not ATP. RNA 10: 558-564. books

Cheng H, He X, Moore C. 2004. The WD repeat protein Swd2 has dual functions in transcription termination and lysine 4 methylation of histone H3.  Mol Cell Biol. 24: 2932-2943. books

Krishnamurthy S, He X, Reyes-Reyes M, Moore C, Hampsey M. 2004. Ssu72 is a novel RNA polymerase II CTD phosphatase. Mol Cell. 14: 387-394. books 

Tacahashi Y, Helmling S, Moore C.  2003. Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor.  Nucleic Acids Res. 31: 1-9. books

He X, Khan A, Cheng H, Pappas D, Hampsey M, Moore C. 2003. Functional interactions between transcription and mRNA 3’ end processing machineries mediated by Ssu72 and Sub1. Genes Dev. 17: 1030-1042. books

Nedea E, He X, Kim M, Pootoolal J, Zhong G, Canadien V, Hughes T, Buratowski S, Moore C, Greenblatt J. 2003. Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem. 278: 33000-33010. books

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