Recent Publications from the Miczek Lab

Research Publications Neuroscience Pharmacology


Niederkofler V, Asher TE, Okaty BW, Rood BD, Narayan A, Hwa LS, Beck SG, Miczek KA, Dymecki SM. 2016. Identification of serotonergic neuronal modules that affect aggressive behavior. Cell Rep. 17: 1934-1949. books

Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA. 2016. Effects of Gabra2 point mutations on alcohol intake: Increased binge-like and blunted chronic drinking by mice. Alcohol Clin Exp Res. 40: 2445-2455. books

Boyson CO, Holly EN, Burke AR, Montagud-Romero S, DeBold JF, Miczek KA. 2016. Maladaptive choices by defeated rats: link between rapid approach to social threat and escalated cocaine self-administration. Psychopharmacology Epub ahead of print. books

Burke AR, DeBold JF, Miczek KA. 2016. CRF type 1 receptor antagonism in ventral tegmental area of adolescent rats during social defeat: prevention of escalated cocaine self-administration in adulthood and behavioral adaptations during adolescence.  Psychopharmacology Epub ahead of print. books

Holly EN, Boyson CO, Montagud-Romero S, Stein DJ, Gobrogge KL, DeBold JF, Miczek KA. 2016. Episodic social stress-escalated cocaine self-administration: Role of phasic and tonic corticotropin releasing factor in the anterior and posterior ventral tegmental area. J Neurosci. 36: 4093-4105.  books

Holly EN, Miczek KA. 2016. Ventral tegmental area dopamine revisited: effects of acute and repeated stress. Psychopharmacology 233: 163-186.  books

Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA. (2016) Dissociation of μ-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addict Biol 21: 111-124  books

Holly EN, Miczek KA. 2015. Capturing individual differences: Challenges in animal models of posttraumatic stress disorder and drug abuse. Biol Psychiatry 78: 816-818.  books

Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW. 2015. The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A 167A: 1993-2008. books

Hwa LS, Holly EN, DeBold JF, Miczek KA. 2015. Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. Psychopharmacology 233: 681-690.  books

Holly EN, DeBold JF, Miczek KA. 2015. Increased mesocorticolimbic dopamine during acute and repeated social defeat stress: modulation by corticotropin releasing factor receptors in the ventral tegmental area. Psychopharmacoloy 232: 4469-4479.  books

Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA. 2015. α2-containing GABAA receptors: a requirement for midazolam-escalated aggression and social approach in mice. Psychopharmacology 232: 4359-4369.  books

Miczek KA, DeBold JF, Hwa LS, Newman EL, de Almeida RM. 2015. Alcohol and violence: neuropeptidergic modulation of monoamine systems. Ann N Y Acad Sci. 1349: 96-118.  books

Albrechet-Souza L, Hwa LS, Han X, Zhang EY, DeBold JF, Miczek KA. 2015. Corticotropin releasing factor binding protein and CRF2 receptors in the ventral tegmental area: Modulation of ethanol binge drinking in C57BL/6J mice. Alcohol Clin Exp Res. 39: 1609-1618.  books

Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW. 2015. The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A 167A: 1993-2008. books

Miczek KA, Takahashi A, Gobrogge KL, Hwa LS, de Almeida RM. 2015. Escalated aggression in animal models: Shedding new light on mesocorticolimbic circuits. Curr Opin Behav Sci. 3: 90-95. books

Burke AR, Miczek KA. 2015. Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior. Psychopharmacology 232: 3067-3079. books

Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. 2015. Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J Neurosci 35: 6452-6463. books

Hwa LS, Nathanson AJ, Shimamoto A, Tayeh JK, Wilens AR, Holly EN, Newman EL, DeBold JF, Miczek KA. 2015. Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice. Psychopharmacology 232:2889-2902. books

Yap JJ, Chartoff EH, Holly EN, Potter DN, Carlezon WA Jr, Miczek KA. 2015. Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area. Psychopharmacology 232: 1555-1569. books

Norman KJ, Seiden JA, Klickstein JA, Han X, Hwa LS, DeBold JF, Miczek KA. 2014. Social stress and escalated drug self-administration in mice I. Alcohol and corticosterone. Psychopharmacology 232:991-1001. books

Han X, Albrechet-Souza L, Doyle MR, Shimamoto A, DeBold JF, Miczek KA. 2014. Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens. Psychopharmacology 232:1003-1010. books

Shimamoto A, Holly EN, Boyson CO, DeBold JF, Miczek KA. 2014. Individual differences in anhedonic and accumbal dopamine responses to chronic social stress and their link to cocaine self-administration in female rats. Psychopharmacology 232: 825-34. books

Quadros IM, Hwa LS, Shimamoto A, Carlson J, DeBold JF, Miczek KA. 2014. Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: Critical role for DRN-PFC serotonin pathway. Neuropsycopharmacology 39: 2874-2883. books

Boyson CO, Holly EN, Shimamoto A, Albrechet-Souza L, Weiner LA, Debold JF, Miczek KA. 2014. Social stress and CRF-dopamine interactions in the VTA: Role in long-term escalation of cocaine self-administration. J Neurosci. 34: 6659-6667. books

Takahashi A, Miczek KA. 2014. Neurogenetics of aggressive behavior: Studies in rodents. Curr Top Behav Neurosci. 17: 3-44. books

Burke AR, Miczek KA. 2013. Stress in adolescence and drugs of abuse in rodent models: Role of dopamine, CRF, and HPA axis. Psychopharmacology 231: 1557-1580. books

Hwa LS, Kalinichev M, Haddouk H, Poli S, Miczek KA. 2013. Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice. Psychopharmacology 231: 333-343. books

Miczek KA, de Boer SF, Haller J. 2013. Excessive aggression as model of violence: a critical evaluation of current preclinical methods. Psychopharmacology 226: 445-458. books

Hwa LS, Debold JF, Miczek KA. 2013. Alcohol in excess: CRF1 receptors in the rat and mouse VTA and DRN. Psychopharmacology 225: 313-327. books

Holly EN, Shimamoto A, Debold JF, Miczek KA. 2012. Sex differences in behavioral and neural cross-sensitization and escalated cocaine taking as a result of episodic social defeat stress in rats. Psychopharmacology 224: 179-188. books

Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC, Wang J, Paul IA, Woolverton WL, Seo S, Sittman DB, Ou XM 2012. Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J Biol Chem. 287: 24195-22406. books

Newman EL, Chu A, Bahamón B, Takahashi A, Debold JF, Miczek KA. 2012. NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice. Psychopharmacology 224: 167-177. books

Takahashi A, Quadros IM, de Almeida RM, Miczek KA.  2012. Behavioral and pharmacogenetics of aggressive behavior. Curr Top Behav Neurosci. 12: 73-138. books

Takahashi A, Schilit AN, Kim J, Debold JF, Koide T, Miczek KA. 2012. Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus. Psychopharmacology 224: 155-166. books

Faccidomo S, Quadros IM, Takahashi A, Fish EW, Miczek KA.  2012. Infralimbic and dorsal raphé microinjection of the 5-HT(1B) receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice. Psychopharmacology 222: 117-128. books

Miczek KA, de Almeida RM.  2012. The case for basic research on the psychopharmacology of aggression. J Clin Psychopharmacol. 32: 1-2. books

Miczek KA, Nikulina EM, Shimamoto A, Covington HE 3rd.  2011. Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats. J Neurosci. 31: 9848-9857. books

Furay AR, McDevitt RA, Miczek KA, Neumaier JF.  2011. 5-HT1B mRNA expression after chronic social stress. Behav Brain Res. 224: 250-257. books

Shimamoto A, Debold JF, Holly EN, Miczek KA.  2011. Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. Psychopharmacology 218: 271-279. books

Hwa LS, Chu A, Levinson SA, Kayyali TM, DeBold JF, Miczek KA.  2011. Persistent escalation of alcohol drinking in C57BL/6J mice with intermittent access to 20% ethanol. Alcohol Clin Exp Res. 35: 1938-1947. books

Boyson CO, Miguel TT, Quadros IM, Debold JF, Miczek KA.  2011. Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA. Psychopharmacology 218: 257-269. books

Miczek KA, Nikulina EM, Takahashi A, Covington HE 3rd, Yap JJ, Boyson CO, Shimamoto A, de Almeida RM.  2011. Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuse. Behav Genet. 41: 787-802. books

Cruz FC, Quadros IM, Hogenelst K, Planeta CS, Miczek KA. 2011. Social defeat stress in rats: escalation of cocaine and "speedball" binge self-administration, but not heroin. Psychopharmacology 215: 165-175. books

da Veiga CP, Miczek KA, Lucion AB, de Almeida RM. 2011. Social instigation and aggression in postpartum female rats: role of 5-Ht(1A) and 5-Ht (1B) receptors in the dorsal raphé nucleus and prefrontal cortex. Psychopharmacology 213: 475-487. books

Takahashi A, Quadros IM, de Almeida RM, Miczek KA. 2011. Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression. Psychopharmacology 213: 183-212. books

Takahashi A, Shimamoto A, Boyson CO, DeBold JF, Miczek KA. 2010. GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice. J Neurosci. 30: 11771-1180. books

Takahashi A, Kwa C, Debold JF, Miczek KA. 2010. GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption. Psychopharmacology  211: 467-477. books

Carlezon WA Jr, Miczek KA. 2010. Ascent of the kappa-opioid receptor in psychopharmacology. Psychopharmacology 210: 107-108. books

Pautassi RM, Camarini R, Quadros IM, Miczek KA, Israel Y. 2010. Genetic and environmental influences on ethanol consumption: perspectives from preclinical research. Alcohol Clin Exp Res. 34: 976-987. books

Velez L, Sokoloff G, Miczek KA, Palmer AA, Dulawa SC. 2010. Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains. Behav Genet. 40: 201-210. books

Quadros IM, Miczek KA. 2009. Two modes of intense cocaine bingeing: increased persistence after social defeat stress and increased rate of intake due to extended access conditions in rats. Psychopharmacology  206: 109-120. books

Takahashi A, Yap JJ, Bohager DZ, Faccidomo S, Clayton T, Cook JM, Miczek KA. 2009. Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology 204: 61-71. books

Miczek KA, Yap JJ, Covington HE 3rd. 2008. Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake. Pharmacol Ther. 120: 102-128. books

Cruz FC, Quadros IM, Planeta Cda S, Miczek KA. 2008. Maternal separation stress in male mice: long-term increases in alcohol intake. Psychopharmacology 201:459-468. books

Centenaro LA, Vieira K, Zimmermann N, Miczek KA, Lucion AB, de Almeida RM. 2008. Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex. Psychopharmacology 201: 237-248. books

McKenzie-Quirk SD, Miczek KA. 2008. Social rank and social separation as determinants of alcohol drinking in squirrel monkeys. Psychopharmacology 201: 137-145. books

Miczek KA, de Wit H. 2008. Youth violence. Challenges for translational psychopharmacology research--some basic principles. Psychopharmacology 199: 291-301. books

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