Recent Publications from the Meydani Lab

Research Publications Immunology


Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A. 2017. The Alpha-tocopherol form of Vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae. Front Cell Infect Microbiol. 7:161.  books

Karl JP, Meydani M, Barnett JB, Vanegas SM, Goldin B, Kane A, Rasmussen H, Saltzman E, Vangay P, Knights D, Chen CO, Das SK, Jonnalagadda SS, Meydani SN, Roberts SB. 2017. Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women. Am J Clin Nutr. Epub ahead of print. books

Vanegas SM, Meydani M, Barnett JB, Goldin B, Kane A, Rasmussen H, Brown C, Vangay P, Knights D, Jonnalagadda S, Koecher K, Karl JP, Thomas M, Dolnikowski G, Li L, Saltzman E, Wu D, Meydani SN. 2017. Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults. Am J Clin Nutr. Epub ahead of print. books

Chung H, Wu D, Smith D, Meydani SN, Han SN. 2016. Lower hepatic iron storage associated with obesity in mice can be restored by decreasing body fat mass through feeding a low-fat diet. Nutr Res. 36: 955-963. books

Azzi A, Meydani SN, Meydani M, Zingg JM. 2016. The rise, the fall and the renaissance of vitamin E. Arch Biochem Biophys. 595: 100-108. books

Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L. 2016. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. Aging Epub ahead of print. books

Barnett JB, Dao MC, Hamer DH, Kandel R, Brandeis G, Wu D, Dallal GE, Jacques PF, Schreiber R, Kong E, Meydani SN. 2016. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 103: 942-951. books

Rozati M, Barnett J, Wu D, Handelman G, Saltzman E, Wilson T, Li L, Wang J, Marcos A, Ordovás JM, Lee YC, Meydani M, Meydani SN. 2015. Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial. Nutr Metab (London) 12: 28. books

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN. 2014. The α-yocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 194: 1090-1099. books

Wu D, Meydani SN. 2014. Age-associated changes in immune function: Impact of vitamin E intervention and the underlying mechanisms. Endocr Metab Immune Disord Drug Targets 14: 283-289. books

El-Abbadi NH, Dao MC, Meydani SN. 2014. Yogurt: role in healthy and active aging. Am J Clin Nutr. 99: 1263S-1270S. books

Sen S, Iyer C, Meydani SN. 2013. Obesity during pregnancy alters maternal oxidant balance and micronutrient status. J Perinatol. 34: 105-111. books

Dao MC, Meydani SN. 2013. Iron biology, immunology, aging, and obesity: Four fields connected by the small peptide hormone hepcidin. Adv Nutr. 4: 602-617. books

Economos CD, Moore CE, Hyatt RR, Kuder J, Chen T, Meydani SN, Meydani M, Klein E, Biancuzzo RM, Holick MF. 2013. Multinutrient-fortified juices improve vitamin D and vitamin E status in children: A randomized controlled trial. J Acad Nutr Diet 114: 709-717. books

Kawai K, Meydani SN, Urassa W, Wu D, Mugusi FM, Saathoff E, Bosch RJ, Villamor E, Spiegelman D, Fawzi WW. 2013. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiol Infect. 7: 1-5. books

Zingg JM, Han SN, Pang E, Meydani M, Meydani SN, Azzi A. 2013. In vivo regulation of gene transcription by alpha- and gamma-tocopherol in murine T lymphocytes. Arch Biochem Biophys. 538: 111-119. books

Wang J, Pae M, Meydani SN, Wu D. 2013. Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4⁺ T cells into specific lineage effector cells. J Mol Med (Berl) 91: 485-495. books

Sudfeld CR, Duggan C, Histed A, Manji KP, Meydani SN, Aboud S, Wang M, Giovannucci EL, Fawzi WW. 2013. Effect of multivitamin supplementation on measles vaccine response among HIV-exposed uninfected Tanzanian infants. Clin Vaccine Immunol. 20: 1123-1132. books

Wang J, Vanegas SM, Du X, Noble T, Zingg JM, Meydani M, Meydani SN, Wu D. 2013. Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit. Nutr Metab (Lond) 10: 29. books

Sen S, Iyer C, Klebenov D, Histed A, Aviles JA, Meydani SN. 2013. Obesity impairs cell-mediated immunity during the second trimester of pregnancy. Am J Obstet Gynecol. 208: 139.e1-8. books

Wu D, Ren Z, Pae M, Han SN, Meydani SN. 2013. Diet-induced obesity has a differential effect on adipose tissue and macrophage inflammatory responses of young and old mice. Biofactors 39: 326-333. books

Xu Y, Na L, Ren Z, Xu J, Sun C, Smith D, Meydani SN, Wu D. 2013. Effect of dietary supplementation with white button mushrooms on host resistance to influenza infection and immune function in mice. Br J Nutr. 109: 1052-1061. books

Dao MC, Sen S, Iyer C, Klebenov D, Meydani SN. 2013. Obesity during pregnancy and fetal iron status: is Hepcidin the link? J Perinatol. 33: 177-181. books

Han SN, Lichtenstein AH, Ausman LM, Meydani SN. 2012. Novel soybean oils differing in Fatty Acid composition alter immune functions of moderately hypercholesterolemic older adults. J Nutr. 142: 2182-2187. books

Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN. 2012. Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. PLoS One 7: e47650. books

Pae M, Meydani SN, Wu D. 2012. The role of nutrition in enhancing immunity in aging. Aging Dis. 3: 91-129. books

Ren Z, Na L, Xu Y, Rozati M, Wang J, Xu J, Sun C, Vidal K, Wu D, Meydani SN. 2012. Dietary supplementation with lacto-wolfberry enhances the immune response and reduces pathogenesis to influenza infection in mice. J Nutr. 142: 1596-1602. books

Meydani SN, Beck MA. 2012. The relationship of host nutritional status to immune function. Mol Aspects Med. 33: 1. books

Wang J, Pae M, Meydani SN, Wu D. 2012. Epigallocatechin-3-Gallate inhibits expression of receptors for T cell regulatory cytokines and their downstream signaling in mouse CD4+ T cells. J Nutr. 142: 566-571. books

Molano A, Meydani SN. 2012. Vitamin E, signalosomes and gene expression in T cells. Mol Aspects Med. 33: 55-62. books

Wang J, Ren Z, Xu Y, Xiao S, Meydani SN, Wu D. 2012. Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets. Am J Pathol. 180: 221-234. books

Wu D, Wang J, Pae M, Meydani SN. 2012. Green tea EGCG, T cells, and T cell-mediated autoimmune diseases. Mol Aspects Med. 33: 107-118. books

Pae M, Ren Z, Meydani M, Shang F, Smith D, Meydani SN, Wu D. 2012. Dietary supplementation with high dose of epigallocatechin-3-gallate promotes inflammatory response in mice. J Nutr Biochem. 23: 526-531. books

Vergidis P, Hamer DH, Meydani SN, Dallal GE, Barlam TF. 2011. Patterns of antimicrobial use for respiratory tract infections in older residents of long-term care facilities. J Am Geriatr Soc. 59: 1093-1098. books

Delgado-Lista J, Garcia-Rios A, Perez-Martinez P, Solivera J, Yubero-Serrano EM, Fuentes F, Parnell LD, Shen J, Gomez P, Jimenez-Gomez Y, Gomez-Luna MJ, Marin C, Belisle SE, Rodriguez-Cantalejo F, Meydani SN, Ordovas JM, Perez-Jimenez F, Lopez-Miranda J. 2011. Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism. J Clin Endocrinol Metab. 96: E816-820. books

Guo W, Nie L, Wu D, Wise ML, Collins FW, Meydani SN, Meydani M. 2011. Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro. Nutr Cancer 62: 1007-1016. books

Sempértegui F, Estrella B, Tucker KL, Hamer DH, Narvaez X, Sempértegui M, Griffiths JK, Noel SE, Dallal GE, Selhub J, Meydani SN. 2011. Metabolic syndrome in the elderly living in marginal peri-urban communities in Quito, Ecuador. Public Health Nutr. 14: 758-767. books

Pae M, Ren Z, Meydani M, Shang F, Meydani SN, Wu D. 2010. Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression. J Nutr. 140: 1509-1515. books

Ren Z, Pae M, Dao MC, Smith D, Meydani SN, Wu D. 2010. Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr. 140:1335-1340. books

Barnett JB, Hamer DH, Meydani SN. 2010. Low zinc status: a new risk factor for pneumonia in the elderly? Nutr Rev. 68: 30-37. books

Han SN, Pang E, Zingg JM, Meydani SN, Meydani M, Azzi A. 2010. Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes. Arch Biochem Biophys. 495: 49-55. books

Mernitz H, Lian F, Smith DE, Meydani SN, Wang XD. 2009. Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse. Nutr Cancer 61: 663-669. books

Ren Z, Gay R, Thomas A, Pae M, Wu D, Logsdon L, Mecsas J, Meydani SN. 2009. Effect of age on susceptibility to Salmonella typhimurium infection in C57BL/6 mice. J Med Microbiol. 58:1559-1567. books

Belisle SE, Leka LS, Delgado-Lista J, Jacques PF, Ordovas JM, Meydani SN. 2009. Polymorphisms at cytokine genes may determine the effect of vitamin E on cytokine production in the elderly. J Nutr. 139: 1855-1860. books

Ahmed T, Das SK, Golden JK, Saltzman E, Roberts SB, Meydani SN. 2009. Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women. J Gerontol A Biol Sci Med Sci. 64: 1107-1113. books

Wu D, Guo Z, Ren Z, Guo W, Meydani SN. 2009. Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling. 47: 636-643. books

Meydani SN, Hamer DH. 2009. Zinc supplementation in elderly nursing home residents. 49: 479. books

Marko MG, Pang HJ, Ren Z, Azzi A, Huber BT, Bunnell SC, Meydani SN. 2009. Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice. J. Nutr 139: 1192-1197. books

Hamer DH, Sempértegui F, Estrella B, Tucker KL, Rodríguez A, Egas J, Dallal GE, Selhub J, Griffiths JK, Meydani SN. 2008. Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians. J Nutr 139: 113-119. books

Meydani SN, Wu D. 2008. Nutrition and age-associated inflammation: implications for disease prevention. J Parenter Enteral Nutr 32: 626-629. books

Wu D, Meydani SN. 2008. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol 84: 900-914. books

Falsey AR, Dallal GE, Formica MA, Andolina GG, Hamer DH, Leka LL, Meydani SN. 2008. Long-term care facilities: A cornucopia of viral pathogens. J Am Geriatr Soc 56:1281-1285. books

Belisle SE, Leka LS, Dallal GE, Jacques PF, Delgado-Lista J, Ordovas JM, Meydani SN. 2008. Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels. Biofactors 33: 191-200. books

Villamor E, Mugusi F, Urassa W, Bosch RJ, Saathoff E, Matsumoto K, Meydani SN, Fawzi WW. 2008. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J Infect Dis 197: 1499-1505. books

Ahmed T, Hamer DH, Meydani SN. 2008. Effects of repeated administration of intradermal skin test by Mantoux method on delayed-type hypersensitivity responses in healthy young and elderly subjects. Br J Nutr 98: 1388-1390. books

Ren Z, Guo Z, Meydani SN, Wu D. 2008. White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice. J Nutr 138: 544-550. books

Meydani SN, Wu D. 2007. Age-associated inflammatory changes: role of nutritional intervention. Nutr Rev 65: S213-216. books

Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, Hamer DH. 2007. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 86: 1167-1173. books

Wu D, Ren Z, Pae M, Guo W, Cui X, Merrill AH, Meydani SN. 2007. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J Immunol 179: 4829-2839. books

Wu D, Pae M, Ren Z, Guo Z, Smith D, Meydani SN. 2007. Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice. J Nutr 137: 1472-1477. books

Marko MG, Ahmed T, Bunnell SC, Wu D, Chung H, Huber BT, Meydani SN. 2007. Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation. J Immunol 178:1443-1449. books

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