Recent Publications from the McVey Lab

Research Publications Genetics

 

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Scharer O, McVey M. 2017. Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair. PLoS Genet. 13: e1006813. books

McVey M, Khodaverdian VY, Meyer D, Cerqueira PG, Heyer WD. 2016. Eukaryotic DNA polymerases in homologous recombination. Ann Rev Genet. 50: 393-421. books

Alexander JL, Beagan K, Orr-Weaver TL, McVey M. 2016. Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells. Proc Natl Acad Sci USA 113: 13809-13814. books

Beagan K, McVey M. 2016. Linking DNA polymerase theta structure and function in health and disease. Cell Mol Life Sci 73: 603-615. books

Rodgers K, McVey M. 2015. Error-prone repair of DNA double-strand breaks. J Cell Physiol. 231: 15-24. books

Kloosterman WP, Francioli LC Hormozdiari F, Marschall T, Hehir-Kwa JY, Abdellaoui A, Lameijer EW, Moed MH, Koval V, Renkens I, van Roosmalen MJ, Arp P, Karssen LC, Coe BP, Handsaker RE, Suchiman ED, Cuppen E, Thung DT, McVey M, Wendl MC, Uitterlinden A, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Schönhuth A, Eichler EE, de Bakker PI, Ye K, Guryev V. 2015. Characteristics of de novo structural changes in the human genome. Genome Res. 25: 792-801. books

McVey M. 2014. RPA puts the brakes on MMEJ. Nat Struct Mol Biol. 21: 348-349. books

Bolterstein E, Rivero R, Marquez M, McVey M. 2014. The drosophila werner exonuclease participates in an exonuclease-independent response to replication stress. Genetics 197: 643-652. books

Thomas AM, Hui C, South A, McVey M. 2013. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2. G3 (Bethesda) 3: 91-99. books

Kane DP, Shusterman M, Rong Y, McVey M. 2012. Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. PLoS Genet. 8: e1002659. books

Garcia AM, Salomon RN, Witsell A, Liepkalns J, Calder RB, Lee M, Lundell M, Vijg J, McVey M. 2011. Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biol. 12: R121. books

Chan SH, Yu AM, McVey M. 2010. Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila. PLoS Genetics 6: e1001005. books

Yu AM, McVey M. 2010. Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. Nucleic Acids Res. 38: 5706-5717. books

McVey, M. 2010. In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair. Methods Mol Biol. 587: 185-194. books

McVey, M. 2010. Strategies for DNA interstrand crosslink repair: Insights from worms, flies, frogs, and slime molds. Environ Mol Mutagen 51: 646-658. books

Witsell A, Kane DP, McVey M. 2010. Super-sized deletions: Improved transposon excision screens using a mus309 mutant background. Fly (Austin) 4: 137-140. books

Witsell A, Kane DP, Rubin S, McVey M. 2009. Removal of the Bloom Syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila. Genetics 183: 1187-1193. books

McVey M, Lee SE. 2008. MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet. 24: 529-538. books

McVey M, Andersen S, Broze GJ, Sekelsky JJ. 2007. Multiple roles for the Drosophila DmBlm helicase in maintenance of genome stability. Genetics 176: 1979-1992. books

Rybarczyk BJ, Baines AT, McVey M, Thompson JT, Wilkins HR. 2007. A case-based approach increases student learning outcomes and comprehension of cellular respiration concepts. Biochem Mol Biol Ed. 35: 181-186. Abstract in PubMed

McVey M, Radut D, Sekelsky JJ. 2004. End-joining repair of double-strand breaks in Drosophila is largely DNA ligase IV independent. Genetics 168: 2067-2076. books

McVey M, LaRocque JR, Adams MD, Sekelsky JJ. 2004. Formation of deletions during double strand break repair in Drosophila DmBlm mutants occurs after strand invasion. Proc Natl Acad Sci USA 101: 15694-15699. books

McVey M, Adams MD, LaRocque J, Sekelsky JJ. 2004. Evidence for multiple cycles of strand invasion during repair of double-strand gaps in Drosophila. Genetics 167: 699-705. books

Baines AT, McVey M, Rybarczyk B, Thompson JT, Wilkins HR. 2004. The mystery of the toxic flea dip: an interactive approach to teaching aerobic cellular respiration. Cell Biol Ed. 3: 62-68. Abstract in PubMed

Adams MD, McVey M, Sekelsky JJ. 2003. Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science 299: 265-267. books

McVey M, Kaeberlein M, Tissenbaum HA, Guarente L. 2001. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157: 1531-1542. books

Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L. 2001. The Saccharomyces cerevisiae WRN homologue Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 20: 905-913. books

Stone EM, Reifsnyder C, McVey M, Gazo B, Pillus L. 2000. Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae. Genetics 155: 509-522. books

Kaeberlein M, McVey M, Guarente L. 1999. SIR2/3/4 and SIR2 alone regulate life span in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13: 2570-2780. books

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