Recent Publications from the Maguire Lab

Research Publications Neuroscience Pharmacology


Maguire J. 2018. J Physiol. The relationship between GABA and stress… "it's complicated". J Physiol. Epub ahead of print. books

Hooper A, Fuller PM, Maguire J. 2018. Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability. PLoS One 13: e0191363. books

Melón LC, Hooper A, Yang X, Moss SJ, Maguire J. 2017. Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology Epub ahead of print. books

Hooper A, Paracha R, Maguire J. 2017. Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors. Epilepsy Behav. 78: 124-133. books

Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ. 2017. Proc Natl Acad Sci USA 114: 11763-11768. books

Davis P, Zaki Y, Maguire J, Reijmers LG. 2017. Cellular and oscillatory substrates of fear extinction learning. Nat Neurosci. 20: 1624-1633. books

Fuchs T, Jefferson SJ, Hooper A, Yee PP, Maguire J, Luscher B. 2017. Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors. Mol Psychiatry 22: 787. books

Maguire J. 2016. Synaptic plasticity and context-dependent behavioral responses expand the repertoire of stress reactivity (retrospective on DOI 10.1002/bies.201300178). Bioessays 38: 1066-1067.  books

MacKenzie G, O'Toole KK, Maguire J. 2016. Compromised GABAergic inhibition contributes to tumor-associated epilepsy. Epilespy Res 126:185-196. books

Lee V, MacKenzie G, Hooper A, Maguire J. 2016. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus Epub ahead of print. books

Maguire J, Mody I. 2016. Behavioral deficits in juveniles mediated by maternal stress hormones in mice. Neural Plast. 2016:2762518.  books

Camille Melón L, Maguire J. 2015. GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function. J Steroid Biochem Mol Biol. Epub ahead of print. books

Sivakumaran S, Maguire J. 2015. Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. Epilepsia 57: 222-232. books

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. 2015. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci USA 112: 14805-14810. books

Hooper A, Maguire J 2015. Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus 26: 41-53.   books

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. 2015. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices in vitro and in vivo. J Neurosci. 35: 8291-8286. books

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci USA 111: 3523-3528. books

MacKenzie G, Maguire J. 2015. Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. Epilepsy Res. 109C:13-27. Abstract in PubMed

Andresen L, Hampton D, Taylor A, Morel L, Yang Y, Maguire J, Dulla CG. 2014. Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Neurobiol Dis. 71: 305-316. Abstract in PubMed

Maguire J. 2014. Stress-induced plasticity of GABAergic inhibition. Front Cell Neurosci. 8: 157. books

Abramian AM, Comenencia-Ortiz E, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. 2014. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Sci. USA 111: 7132-7137. books

Maguire J. 2014. Plasticity in the GABAergic regulation of the HPA axis. Bioessays 36: 546. books

Lee V, Maguire J. 2014. The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type. Front Neural Circuits 8: 3. books

Lee V, Sarkar J, Maguire J. 2014. Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology 41: 75-88. books

Mackenzie G, Maguire J. 2014. The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders. Psychopharmacol (Berl) 231: 3333-3342. books

O'Toole KK, Hooper A, Wakefield S, Maguire J. 2014. Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res. 108: 29-43. books

Lee V, Maguire J. 2013. Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 110: 2520-2535. books

Maguire J, Salpekar JA. 2013. Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy. Epilepsy Behav. 26: 352-362. books

Deeb TZ, Maguire J, Moss SJ. 2012. Possible alterations in GABA(A) receptor signaling that underlie benzodiazepine-resistant seizures. Epilepsia 53 Suppl 9: 79-88. books

Mody I, Maguire J. 2011. The reciprocal regulation of stress hormones and GABA(A) receptors. Front Cell Neurosci. 6:4. books

Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. 2011. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J. Neurosci. 31: 18198-18210. books

Hines RM, Davies PA, Moss SJ, Maguire J.  2011. Functional regulation of GABA(A) receptors in nervous system pathologies. Curr Opin Neurobiol. 22: 552-558. books

Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC, Cope DW. 2009. Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci. 29: 12757-12763. books

Maguire J, Mody I. 2009. Steroid hormone fluctuations and GABAAR plasticity. Psychoneuroendocrinology. Suppl 1: S84-S90. books

Maguire J, Ferando I, Simonsen C, Mody I. 2009. Excitability changes related to GABAA receptorplasticity during pregnancy. J Neurosci. 29: 9592-9601. books

Maguire J, Mody I.  2008  GABAA receptor plasticity during pregnancy: Relevance to postpartum depression.  Neuron 592: 207 – 213. books

Maguire J, Mody I.  2007.  Neurosteroid synthesis-mediated regulation of GABAA receptors: Relevance to ovarian cycle and stress.  J Neurosci.  27: 2155–2162. books

Klaassen A, Glykys J, Maguire J, Labarca C, Mody I, Boulter J. 2006. Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.  Proc Natl Acad Sci USA. 103: 19152-19157. books

Maguire JL, Stell BM, Rafizadeh M, Mody I. 2005. Ovarian cycle-linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety.  Nature Neurosci. 8: 797-804. books

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