Recent Publications from the Leong Lab

Research Publications Immunology Microbiology


Lin YP, Leong JM. 2017. Characterization of Borrelia burgdorferi binding to mammalian cells and extracellular matrix. Methods Mol Biol 1690: 57-67. books

Caine JA, Lin YP, Kessler JR, Sato H, Leong JM, Coburn J. 2017. Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival. Cell Microbiol. Epub ahead of print.  books

Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA 2017. Cytosolic phospholipase A2α promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection. Infect Immun. Epub ahead of print. books

Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A. 2017. The Alpha-tocopherol form of Vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae. Front Cell Infect Microbiol. 7:161.  books

Flowers LJ, Bou Ghanem EN, Leong JM. 2016. Synchronous disease kinetics in a murine model for enterohemorrhagic E. coli infection using food-borne inoculation. Front Cell Infect Microbiol. 6:138. Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic E. coli Infection Using Food-Borne Inoculation. books

Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM. 2016. A novel Zak knockout mouse with a defective ribotoxic stress response. Toxins (Basel) 8: 9. books

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.  books

Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U. 2015. Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cell Microbiol. 18: 97-110.  books

Lin YP, Bhowmick R, Coburn J, Leong JM. 2015. Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cell Microbiol. 17: 1464-1476. books

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN. 2014. The α-yocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 194: 1090-1099. books

Lin YP, Chen Q, Ritchie JA, Dufour NP, Fischer JR, Coburn J, Leong JM. 2014. Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization. Cell Microbiol. 17: 860-875. books

DesRochers TM, Kimmerling EP, Jandhyala DM, El-Jouni W, Zhou J, Thorpe C, Leong JM, Kaplan DL. 2014. The effects of shiga toxin type 2 on a bioengineered 3D model of human renal tissue. Infect Immun. 83: 28-38. books

Lin YP, Benoit V, Yang X, Martínez-Herranz R, Pal U, Leong JM. 2014. Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the Lyme disease spirochete. PLoS Pathog. 10: PLoS Pathog. 10: e1004238. books

Battle SE, Brady MJ, Vanaja SK, Leong JM, Hecht GA. 2014. Infect Immun. Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation. 82: 3713-3722. books

Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS. 2014. Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infect Immun. 82: 3186-3198. books

Kailasan Vanaja S, Rathinam VA, Atianand MK, Kalantari P, Skehan B, Fitzgerald KA, Leong JM. 2014. Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome. Proc Natl Acad Sci USA 111: 7765-7770. books

Bhowmick R, Tin Maung NH, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM. 2013. Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. J Immunol. 191: 5115-5123.  books

Jandhyala DM, Vanguri V, Boll EJ, Lai Y, McCormick BA, Leong JM. 2013. Shiga toxin-producing Escherichia coli O104:H4: An emerging pathogen with enhanced virulence. Infect Dis Clin North Am. 27: 631-649.  books

Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G. 2012. Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Mol Microbiol. 86: 1116-1131. books

Mallick EM, McBee ME, Vanguri VK, Melton-Celsa AR, Schlieper K, Karalius BJ, O'Brien AD, Butterton JR, Leong JM, Schauer DB. 2012. A novel murine infection model for Shiga toxin-producing Escherichia coli. J Clin Invest. 122: 4012-4024. books

Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 80: 4071-4077. books

Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P. 2012. Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure 20: 1692-1703. books

Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA. 2012. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell 150: 609-619. books

Campellone KG, Siripala AD, Leong JM, Welch MD. 2012.Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli. J Biol Chem. 287: 20613-20624. books

Mallick EM, Brady MJ, Luperchio SA, Vanguri VK, Magoun L, Liu H, Sheppard BJ, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM, Schauer DB. 2012. Allele- and tir-independent functions of intimin in diverse animal infection models. Front Microbiol. 3: 11.  books

Flockhart AF, Tree JJ, Xu X, Karpiyevich M, McAteer SP, Rosenblum R, Shaw DJ, Low CJ, Best A, Gannon V, Laing C, Murphy KC, Leong JM, Schneiders T, La Ragione R, Gally DL. 2012. Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion. Mol Microbiol. 83: 208-223.  books

Brady MJ, Radhakrishnan P, Liu H, Magoun L, Murphy KC, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM. 2011. Enhanced actin pedestal formation by enterohemorrhagic Escherichia coli O157:H7 adapted to the mammalian host. Front Microbiol. 2: 226.  books

Lai Y, Riley K, Cai A, Leong JM, Herman IM. 2011. Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli. Front Microbiol. 2: 222. books

de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE. 2011. Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure 19: 1297-1306. books

Lesser CF, Leong JM. 2011. Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes.  Sci Signal. 4: pe32. books

Benoit VM, Fischer JR, Lin YP, Parveen N, Leong JM. 2011. Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells. Infect Immun. 79: 3501-3509.  books

Piscatelli H, Kotkar SA, McBee ME, Muthupalani S, Schauer DB, Mandrell RE, Leong JM, Zhou D. 2011. The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. PLoS One 6: e19331. books

Tree JJ, Roe AJ, Flockhart A, McAteer SP, Xu X, Shaw D, Mahajan A, Beatson SA, Best A, Lotz S, Woodward MJ, La Ragione R, Murphy KC, Leong JM, Gally DL. 2011. Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7. Mol Microbiol. 80: 1349-1365. books

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ. 2011. Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.  PLoS Pathog. 7: e1001332. books

Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P. 2010. Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Proc Natl Acad Sci USA 107: 21743-21748. books

Vingadassalom D, Campellone KG, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, Leong JM. 2010.  Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation. PLoS Pathog. 6: e1001056. books

Liu H, Fitzgerald D, Gran B, Leong JM, Alugupalli KR. 2010.  Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. J Immunol. 184: 5859-5864. books

Hayward RD, Goguen JD, Leong JM. 2010. No better time to FRET: shedding light on host pathogen interactions. J Biol. 9: 12. books

Benoit VM, Petrich A, Alugupalli KR, Marty-Roix R, Moter A, Leong JM, Boyartchuk VL. 2010. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infect Immun. 78: 586-594.  books

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