Recent Publications from the Hu Lab

Research Publications Immunology Microbiology


Petnicki-Ocwieja T, Hu LT. 2017. Magnetic isolation of phagosomes containing Toll-like receptor ligands. Methods Mol Biol. 1690: 329-336. books

Killpack TL, Ballesteros M, Bunnell SC, Bedugnis A, Kobzik L, Hu LT, Petnicki-Ocwieja T. 2017. Phagocytic receptors activate Syk and Src signaling during Borrelia burgdorferi phagocytosis. Infect Immun. Epub ahead of print. books

Klein BA, Cornacchione LP, Collins M, Malamy MH, Duncan MJ, Hu LT. 2017. Using Tn-seq to identify pigmentation related genes of Porphyromonas gingivalis: Characterization of the role of a putative glycosyltransferase. J Bacteriol. Epub ahead of print.  books

Ramsey ME, Hyde JA, Medina-Perez DN, Lin T, Gao L, Lundt ME, Li X, Norris SJ, Skare JT, Hu LT. 2017. A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species. PLoS Pathog. Epub ahead of print.  books

Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS. 2016. Lyme borreliosis. Nat Rev Dis Primers 2:16090. books

Hu, L. 2016. Lyme disease. Ann Intern Med. 165: 677.  books

Kern A, Zhou CW, Jia F, Xu Q, Hu LT. 2016. Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release. Vaccine 34: 45078-4513. books

Wang Y, Kern A, Boatright NK, Schiller ZA, Sadowski A, Ejemel M, Souders CA, Reimann KA, Hu L, Thomas WD Jr, Klempner MS. 2016. Pre-exposure prophylaxis with OspA-specific human monoclonal antibodies protects mice against tick transmission of Lyme Disease spirochetes. J Infect Dis. 214: 205-211.  books

Troy EB, Lin T, Gao L, Lazinski DW, Lundt M, Camilli A, Norris SJ, Hu LT. 2016. Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi. Mol Microbiol. 101: 1003-1023.  books

Sanchez E, Vannier E, Wormser GP, Hu LT. 2016. Diagnosis, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: A review. JAMA. 315: 1767-1777.  books

Klein BA, Chen T, Scott JC, Koenigsberg AL, Duncan MJ, Hu LT. 2015. Identification and characterization of a minisatellite contained within a novel miniature inverted-repeat transposable element (MITE) of Porphyromonas gingivalis Mob DNA 6:18.  books

Petnicki-Ocwieja T, Kern A, Killpack TL, Bunnell SC, Hu LT. 2015. Adaptor protein-3-mediated trafficking of TLR2 ligands controls specificity of inflammatory responses but not adaptor complex assembly. J Immunol. 195: 4331-4340. books

Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. 2015. Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells. Antimicrob Agents Chemother. 59: 4616-4624. books

Klein BA, Duncan MJ, Hu LT. 2015. Defining essential genes and identifying virulence factors of Porphyromonas gingivalis by massively parallel sequencing of transposon libraries (Tn-seq). Methods Mol Biol. 1279:25-43. books

Telford SR 3rd, Hu LT, Marques A. 2014. Is there a place for xenodiagnosis in the clinic? Expert Rev Anti Infect Ther. 12: 1307-1310. books

Scott JC, Klein BA, Duran-Pinedo A, Hu L, Duncan MJ. 2013. A two-component system regulates hemin acquisition in Porphyromonas gingivalis. PLoS One 8: e73351. books

Troy EB, Lin T, Gao L, Lazinski DW, Camilli A, Norris SJ, Hu L. 2013. Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing. Infect Immun. 81: 2347-2357. books

Petnicki-Ocwieja T, Chung E, Acosta DI, Ramos LT, Shin OS, Ghosh S, Kobzik L, Li X, Hu LT. 2013. TRIF mediates TLR2 dependent inflammatory responses to Borrelia burgdorferi. Infect Immun. 81: 402-410. books

Klein BA, Tenorio EL, Lazinski DW, Camilli A, Duncan MJ, Hu LT. 2012. Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis. BMC Genomics 13: 578. books

Hu LT. 2012. In the clinic. Lyme disease. Ann Intern Med. 157: ITC2-2 - ITC2-16. books

Bensaci M, Bhattacharya D, Clark R, Hu LT. 2012. Oral vaccination with vaccinia virus expressing the tick antigen subolesin inhibits tick feeding and transmission of Borrelia burgdorferi. Vaccine 30: 6040-6046. books

Radolf JD, Caimano MJ, Stevenson B, Hu LT. 2011. Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat Rev Microbiol. 10: 87-99. books

Tenorio EL, Klein BA, Cheung WS, Hu LT. 2011. Identification of interspecies interactions affecting Porphyromonas gingivalis virulence phenotypes. J Oral Mircobiol. 3. books

Telford SR 3rd, Cunningham JA, Waltari E, Hu L. 2011. Nest box-deployed bait for delivering oral vaccines to white-footed mice. Ticks Tick Borne Dis. 2: 151-155. books

Bhattacharya D, Bensaci M, Luker KE, Luker G, Wisdom S, Telford SR, Hu LT. 2011. Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease. Vaccine. 29: 7818-7825. books

Petnicki-Ocwieja T, Defrancesco AS, Chung E, Darcy CT, Bronson RT, Kobayashi KS, Hu LT. 2011.  Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance. PLoS One 6: e17414. books

Bhattacharya D, Mecsas J, Hu LT. 2010. Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis. Vaccine 28: 7683-7689. books

Marré ML, Darcy CT, Yinh J, Akira S, Uematsu S, Steere AC, Hu LT. 2010. Role of adrenomedullin in Lyme disease. Infect Immun. 78: 5307-5313. books

Marré ML, Petnicki-Ocwieja T, DeFrancesco AS, Darcy CT, Hu LT. 2010. Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments. PLoS One 5: e12871. books

Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT. 2009. Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol 183: 491-498. books

Heilpern AJ, Wertheim W, He J, Perides G, Bronson RT, Hu LT. 2009. Matrix metalloproteinase 9 plays a key role in lyme arthritis but not in dissemination of Borrelia burgdorferi. Infect Immun. 77: 2643-2649. books

Clark RP,  Hu LT. 2008. Prevention of Lyme disease and other tick-borne infections. Inf Dis Clin N Amer 22: 381-396. books

Shin OS, Isberg RR, Akira S, Uematsu S, Behera AK,  Hu LT. 2008. Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun 76: 2341-2351. books

Behera AK, Durand E, Cugini C, Antonara S, Bourassa L, Hildebrand E, Hu LT, Coburn J. 2008. Borrelia burgdorferi BBB07 interaction with integrin α3β1 stimulates production of pro-inflammatory mediators in primary human chondrocytes. Cell Microbiol 10: 320-331. books

Shin SO, Behera AK, Bronson RT, Hu LT. 2007. Role of novel protein kinase C isoforms in Lyme arthritis. Cell. Microbiol. 9: 1987-1996. books

Scheckelhoff MR, Telford SR, Wesley M, Hu LT. 2007. Borrelia burgdorferi intercepts host hormonal signals to regulate expression of outer surface protein A. Proc Natl Acad Sci USA 104: 7247-7252. books

Klempner MS, Unnasch TR, Hu LT. 2007. Taking a bite out of vector-transmitted infectious diseases. N Engl J Med 356: 2567-2569. books

Medrano M, Ding Y, Wang XG, Lu P, Coburn J, Hu LT. 2007. Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi. J Bacteriol 189: 2653-2659. books

Behera AK, Hildebrand E, Szafranski J, Hung HH, Grodzinsky AJ, Lafyatis R, Koch AE, Kalish R, Perides G, Steere AC, Hu LT. 2006. Role of aggrecanase-1 in Lyme arthritis. Arthr Rheum 54: 3319-3329. books

Behera AK, Hildebrand E, Uematsu S, Akira S, Coburn J, Hu LT. 2006. Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin α3β1. J Immunol 177: 657-664. books

Behera AK, Hildebrand E, Bronson RT, Perides, G, Uematsu S, Akira S, Hu LT. 2006. MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi. Infect Immun 74: 1462-1470. books

Scheckelhoff MR, Telford SR, Hu, LT. 2006. Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs. Vaccine 24: 1949-1947. books

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