Leaderer D, Cashman SM, Kumar-Singh R. 2016. G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection. Exp Eye Res. 145: 380-392.
Leaderer D, Cashman SM, Kumar-Singh R. 2015. Topical application of a G-quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration. Exp Eye Res. 140: 171-178.
Cashman SM, Gracias J, Adhi M, Kumar-Singh R. 2015. Adenovirus mediated delivery of factor H attenuates complement C3 induced pathology in the murine retina: a potential gene therapy for AMD. J Gen Med. 17: 229-243.
Leaderer D, Cashman SM, Kumar-Singh R. 2015. Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59. J Gene Med. 17: 101-115.
Kwong JM, Gu L, Nassiri N, Bekerman V, Kumar-Singh R, Rhee KD, Yang XJ, Hauswirth WW, Caprioli J, Piri N. 2014. AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury. Gene Ther. 22: 138-145.
Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA. 2014. Domain contributions to signaling specificity differences between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF)1 and Ras-GRF2. J Biol Chem. 289: 16551-16564.
Birke MT, Lipo E, Adhi M, Birke K, Kumar-Singh R. 2014. AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice. Gene Ther. 21: 507-513.
Binder C, Cashman SM, Kumar-Singh R. 2013. Extended duration of transgene expression from pegylated POD nanoparticles enables attenuation of photoreceptor degeneration. PLoS One 8: e82295.
Adhi M, Cashman SM, Kumar-Singh R. 2013. Adeno-associated virus mediated delivery of a non-membrane targeted human soluble CD59 attenuates some aspects of diabetic retinopathy in mice. PLoS One 8: e79661.
Birke K, Lipo E, Birke MT, Kumar-Singh R. 2013. Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration. PLoS One 8: e76766.
Lipo EK, Cashman S, Kumar-Singh R. 2013. Aurintricarboxylic acid inhibits complement activation, membrane attack complex and choroidal neovascularization in a model of macular degeneration. Invest Ophthalmol Vis Sci. 54: 7107-7114.
Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA. 2013. Acquisition of contextual discrimination involves the appearance of a Ras-GRF1/p38 map kinase-mediated signaling pathway that promotes LTP. J Biol Chem. 288: 21703-21713.
Greenwald DL, Cashman SM, Kumar-Singh R. 2013. Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa. Gene Ther. 20: 425-434.
Gandhi J, Cashman SM, Kumar-Singh R. 2011. Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endothelium. PLoS One. 6: e21621.
Cashman SM, Ramo K, Kumar-Singh R. 2011. A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration. PLoS One. 6: e19078.
Cashman SM, Desai A, Ramo K, Kumar-Singh R. 2011. Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina. Invest Ophthalmol Vis Sci. 52: 3436-3445.
Binder C, Cashman, SM, Read, SP, Kumar-Singh, R. 2011. Nuclear targeted delivery of macromolecules to retina and cornea. J Gene Med. 13: 158-170.
Sweigard JH, Cashman SM, Kumar-Singh R. 2011. Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: implications for age-related macular degeneration. Gene Ther. 18: 613-621.
Read SP, Cashman SM, Kumar-Singh R. 2010. POD nanoparticles expressing GDNF provide structural and functional rescue of light-induced retinal degeneration in an adult mouse. Mol Ther. 18: 1917-1926.
Ma KN, Cashman SM, Sweigard JH, Kumar-Singh R. 2010. Decay accelerating factor (CD55)-mediated attenuation of complement: therapeutic implications for age-related macular degeneration. Invest Ophthalmol Vis Sci. 51: 6776-6783.
Greenwald DL, Cashman SM, Kumar-Singh R. 2010. Engineered zinc finger nuclease-mediated homologous recombination of the human rhodopsin gene. Invest Ophthalmol Vis Sci. 51: 6374-6380.
Parker Read S, Cashman SM, Kumar-Singh R. 2010. A poly(ethylene) glycolylated peptide for ocular delivery compacts DNA into nanoparticles for gene delivery to post-mitotic tissues in vivo. J Gene Med. 12: 86-96.
Read SP, Cashman SM, Kumar-Singh R. 2010. Gene-based Therapy in Ocular Angiogenesis. In: Therapy of Ocular Angiogenesis: Principles & Practice, Das A and Friberg T, eds, Lippincott Williams & Wilkins, Chapter 15.
Sweigard JH, Cashman S, Kumar-Singh R. 2009. Adenovirus vectors targeting distinct cell types in the retina. Invest Ophthalmol Vis Sci. 51: 2219-2228.
Johnson, LN, Cashman SM, Read SP, Kumar-Singh R. 2009. Cell penetrating peptide POD mediates delivery of recombinant proteins to retina, cornea and skin. Vision Res. 50: 686-697.
Johnson LA, Cashman S, Kumar-Singh R. 2008. Cell penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea. Mol Ther. 16: 107-114.
Ramo K, Cashman S, Kumar-Singh R. 2008. Evaluation of adenovirus-delivered human CD59 as a potential therapy for AMD in a model of human membrane attack complex formation on murine RPE. Invest Ophthalmol Vis Sci. 9: 4126-4136.
Kumar-Singh R. 2008. Barriers for retinal gene therapy: Separating fact from fiction. Vision Res. 48: 1671-1680.
Cashman S, McCullough L, Kumar-Singh R. 2007. Improved retinal transduction in vivo and photoreceptor-specific transgene expression using adenovirus vectors with modified penton base. Mol Ther. 15: 1640-1646.
Menotti-Raymond M, David VA, Schaffer AA, Stephens R, Wells D, Kumar-Singh R, O’Brien SJ, Narfstrom K. 2007. Mutation in CEP290 discovered for cat model of human retinal degeneration. J Hered. 98: 211-220.
Cashman,S., Bowman, L, Christofferson, J. and Kumar-Singh, R. 2006. Inhibition of choroidal neovascularization by adenovirus mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD. Invest Ophthalmol Vis Sci. 47: 3496-3504.
Cashman SM, Binkley EA, Kumar-Singh R. 2005. Towards mutation-independent silencing of genes involved in retinal degeneration by RNA interference. Gene Ther. 12: 1223-1228.
Cashman S, Morris D, Kumar-Singh R. 2004. Adenovirus type 5 pseudotyped with adenovirus type 37 fiber uses sialic acid as a cellular receptor. Virology 324: 129-139.