Recent Publications from the Kumamoto Lab

Research Publications Genetics Microbiology


Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. 2018. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerob Epub ahead of print. books

Regan H, Scaduto C, Hirakawa MP, Gunsalus K, Correia-Mesquita TO, Sun Y, Chen Y, Kumamoto CA, Bennett R, Whiteway M. 2017. Negative regulation of filamentous growth in Candida albicans by Dig1p. Mol Microbiol. 105: 810-824. books

Herwald SE, Zucchi PC, Tan S, Kumamoto CA. 2017. The two transmembrane regions of Candida albicans Dfi1 contribute to its biogenesis. Biochem Biophys Res Commun. 488: 153-158. books

Green ER, Clark S, Crimmins GT, Mack M, Kumamoto CA, Mecsas J. 2016. Fis is essential for Yersinia pseudotuberculosis virulence and protects against reactive oxygen species produced by phagocytic cells during infection. PLoS Pathog. 12: e1005898.   books

Kumamoto CA. 2016. The fungal mycobiota: Small numbers, large impacts. Cell Host Microbe 19: 750-751.   books

Tyc KM, Herwald SE, Hogan JA, Pierce JV, Klipp E, Kumamoto CA. 2016. The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression. BMC Syst Biol. 10: 20.   books

Gunsalus KT, Kumamoto CA. 2016. Transcriptional profiling of Candida albicans in the host. Methods Mol Biol. 1356:17-29.   books

Gunsalus KT, Tornberg-Belanger SN, Matthan NR, Lichtenstein AH, Kumamoto CA.. 2015. Manipulation of host diet to reduce gastrointestinal colonization by the opportunistic pathogen Candida albicans. mSphere 1: pii: e00020-15.  books

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL 2015. Robust bioengineered 3D functional human intestinal epithelium. Sci Rep. 5: 13708.   books

Tebbji F, Chen Y, Richard Albert J, Gunsalus KT, Kumamoto CA, Nantel A, Sellam A, Whiteway M. 2014. A functional portrait of Med7 and the mediator complex in Candida albicans. PLoS Genet. 10: e1004770. books

Strijbis K, Yilmaz OH, Dougan SK, Esteban A, Gröne A, Kumamoto CA, Ploegh HL. 2014. Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. PLoS One 9: e112472. books

Herwald SE, Kumamoto CA 2014. Candida albicans niche specialization: Features that distinguish biofilm cells from commensal cells. Curr Fungal Infect Rep. 8: 179-184. books

Davis TR, Zucchi PC, Kumamoto CA. 2013. Calmodulin binding to Dfi1p promotes invasiveness of Candida albicans. PLoS One 8: e76239. books

Pérez JC, Kumamoto CA, Johnson AD. 2013. Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLoS Biol. 11: e1001510. books

Pierce JV, Dignard D, Whiteway M, Kumamoto CA. 2013. Normal adaptation of Candida albicans to the murine GI tract requires Efg1p-dependent regulation of metabolic and host defense genes. Eukaryot Cell 12: 37-49. books

Pierce JV, Kumamoto CA. 2012. Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations. MBio. 3: e00117-e00112. books

Petrovska I, Kumamoto CA. 2012. Functional importance of the DNA binding activity of Candida albicans Czf1p. Functional importance of the DNA binding activity of Candida albicans Czf1p. PLoS One 7: e39624. books

Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, Mitchell A, Roemer T, Hannun YA, Cammue BP. 2012. The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Mol Microbiol. 84: 166-180. books

Bruzual I, Kumamoto CA. 2012. An MDR1 promoter allele with higher promoter activity is common in clinically isolated strains of Candida albicans. Mol Genet Genomics. 286: 347-357. books

Kumamoto CA, Pierce JV. 2011. Immunosensing during colonization by Candida albicans: does it take a village to colonize the intestine? Trends Microbiol. 19: 263-267. books

Sellam A, Hogues H, Askew C, Tebbji F, van Het Hoog M, Lavoie H, Kumamoto CA, Whiteway M, Nantel A. 2010. Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays. Genome Biol. 11: R71. books

Rosenbach A, Dignard D, Pierce JV, Whiteway M, Kumamoto CA. 2010. Adaptations of Candida albicans for growth in the mammalian intestinal tract. Eukaryot Cell.  9: 1075-1086. books

Zucchi PC, Davis TR, Kumamoto CA. 2010. A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium. Mol Microbiol. 76: 733-748. books

Kumamoto C. 2008. Molecular mechanisms of mechanosensing and their roles in fungal contact sensing. Nat Rev Microbiol. 6:667-673. books

Kumamoto CA. 2008. Niche-specific gene expression during C. albicans infection. Curr Opin Microbiol. 11:325-30. books

White SJ, Rosenbach A, Lephart P, Nguyen D, Benjamin A, Tzipori S, Whiteway M, Mecsas J, Kumamoto CA. 2007. Self-regulation of Candida albicans population size during GI colonization 3: e184. books

Carruthers VB, Cotter PA, Kumamoto CA. 2007. Microbial pathogenesis: mechanisms of infectious disease. Cell Host Microbe 2: 214-219. books

Vinces MD, Kumamoto CA. 2007. The morphogenetic regulator Czf1p is a DNA-binding protein that regulates white opaque switching in Candida albicans. Microbiology. 153: 2877-2884. books

Bruzual I, Riggle P, Hadley S, Kumamoto CA. 2007. Biofilm formation by fluconazole-resistant Candida albicans strains is inhibited by fluconazole. J Antimicrob Chemother. 59: 441-450. books

Chen X, Kumamoto CA. 2006. A conserved G protein (Drg1p) plays a role in regulation of invasive filamentation in Candida albicans. Microbiology 152: 3691-3700. books

Riggle PJ, Kumamoto CA. 2006. Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site. Eukaryot Cell 5:1957-1968. books

LaFleur MD, Kumamoto CA, Lewis K. 2006. Candida albicans biofilms produce antifungal-tolerant persister cells. Antimicrob Agents Chemother 50:3839-3846. books

Vinces MD, Haas C, Kumamoto CA.2006. Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1p. Eukaryot Cell 5: 825-835. books

Kumamoto CA, Vinces MD. 2005. Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence. Cell Microbiol. 7: 1546-1554. books

Kumamoto CA, Vinces MD. 2005. Alternative Candida albicans lifestyles: growth on surfaces. Annu Rev Microbiol. 59:113-33. books

Kumamoto CA. 2005. A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Proc Natl Acad Sci USA 102: 5576-5581. books

Chen X, Magee BB, Dawson D, Magee PT, Kumamoto CA. 2004. Chromosome 1 trisomy compromises the virulence of Candida albicans. Mol Microbiol. 51: 551-565. books

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