Recent Publications from the Kritzer Lab

Research Publications Cell Biology


Slough DP, McHugh SM, Cummings AE, Dai P, Pentelute BL, Kritzer JA, Lin YS. 2018. Designing well-structured cyclic pentapeptides based on sequence-structure relationships. J Phys Chem B Epub ahead of print. books

Kritzer JA, Freyzon Y, Lindquist S. 2018. Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway. FEMS Yeast Res. Epub ahead of print. books

Kamens AJ, Mientkiewicz KM, Eisert RJ, Walz JA, Mace CR, Kritzer JA. 2017. Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorg Med Chem. Epub ahead of print. books

Siegert TR, Bird M, Kritzer JA. 2017. Identifying loop-mediated potein-protein interactions using LoopFinder. Methods Mol Biol. 1561: 255-277. books

Kritzer JA. 2016. Stapled peptides: How to be quick on the uptake. Nat Chem Biol. 12: 764-765. books

Peraro L, Siegert TR, Kritzer JA. 2016. Conformational restriction of peptides using dithiol bis-alkylation. Methods Enzymol. 580:303-332. books

Charkoudian LK, Sampson NS, Kumar K, Kritzer JA 2016. Designing convergent chemistry curricula. Nat Chem Biol. 6: 382-386.  books

Quartararo JS, Eshelman MR, Peraro L, Yu H, Baleja JD, Lin YS, Kritzer JA. 2014. A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorg Med Chem. 22: 6387-6391.  books

Eshelman MR, Aldous AR, Neupane KP, Kritzer JA. 2014. Solution structure of a designed cyclic peptide ligand for nickel and copper ions. Tetrahedron 70: 7651-7654.  books

Gavenonis J, Sheneman BA, Siegert TR, Eshelman MR, Kritzer JA. 2014. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nat Chem Biol. 10: 716-722.  books

Kamens AJ, Eisert RJ, Corlin T, Baleja JD, Kritzer JA. 2014. Structured cyclic peptides that bind the EH domain of EHD1. Biochemistry 53: 4758-4760.  books

Gavenonis J, Jonas NE, Kritzer JA. 2014. Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. Bioorgan Med Chem. 22: 3989-3993.  books

Neupane KP, Aldous AR, Kritzer JA. 2014. Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs. J Inorgan Biochem. 139: 65076.  books

Choudary SK, Qiu J, Plaut AG, Kritzer JA. 2013. Versatile substrates and probes for IgA1 protease activity. Chembiochem. 14: 2007-2012.  books

Neupane KP, Aldous AR, Kritzer JA. 2013. Macrocyclization of the ATCUN motif controls metal binding and catalysis. Inorgan Biochem. 52: 2729-2735.  books

Bock JE, Gavenonis J, Kritzer JA. 2013. Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints. ACS Biochem 8: 488-499.  books

Kritzer JA. 2012. The secret of MIM: a novel, MCL-1-specific small molecule. Chem Biol. 19: 1082-1083.  books

Quartararo JS, Wu P, Kritzer JA. 2012. Peptide bicycles that inhibit the Grb2 SH2 domain. Chembiochem 13: 1490-1496.  books

Kritzer JA. 2010. Grand challenge commentary: Beyond discovery: probes that see, grab and poke. Nat Chem Biol. 6: 868-870.  books

Kritzer JA. 2010. Stapled peptides: Magic bullets in nature's arsenal. Nat Chem Biol. 6: 566-567. books

Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S. 2010. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech. 3: 194-208.  books

Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S. 2009. Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol. 5: 655-663.  books

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