Recent Publications from the Kaplan Lab

Research Publications Cell Biology

 

Du C, Collins W, Cantley W, Sood D, Kaplan DL. 2017. Tutorials for electrophysiological recordings in tissue engineering. ACS Biomater Sci Engineer. Abstract in PubMed

Wang Y, Aurelio D, Li W, Tseng P, Zheng Z, Li M, Kaplan DL, Liscidini M, Omenetto FG. 2017. Modulation of multiscale 3D lattices through conformational control: Painting silk inverse opals with water and light. Adv mater. Epub ahead of print.  books

Plowright R, Belton DJ, Kaplan DL, Perry CC. 2017. Quantifying the efficiency of Hydroxyapatite Mineralising Peptides. Sci Rep. 7: 7681. books

Di Buduo CA, Kaplan DL, Balduini A. 2017. In vitro generation of platelets: Where do we stand? Transfus Clin Biol. Epub ahead of print. books

Huang W, Tarakanova A, Dinjaski N, Wang Q, Xia X, Chen Y, Wong JY, Buehler MJ, Kaplan DL. 2017. Design of multistimuli responsive hydrogels using integrated modeling and genetically engineered silk-elastin-like proteins. Adv Funct Mater. 26: 4113-4123. books

Jacobsen MM, Tokareva OS, Ebrahimi D, Huang W, Ling S, Dinjaski N, Li D, Simon M, Staii C, Buehler MJ, Kaplan DL, Wong JY. 2017. Effect of terminal modification on the molecular assembly and mechanical properties of protein-based block copolymers. Macromol Biosci. Epub ahead of print. books

Grasman JM, Kaplan DL. 2017. Human endothelial cells secrete neurotropic factors to direct axonal growth of peripheral nerves. Sci Rep. 7: 4092. books

Gosselin EA, Torregrosa T, Ghezzi CE, Mendelsohn AC, Gomes R, Funderburgh JL, Kaplan DL. 2017. Multi-layered silk film co-culture system for human corneal epithelial and stromal stem cells. Tissue Eng Regen Med. Epub ahead of print.  books

Bradner SA, Partlow BP, Cebe P, Omenetto FG, Kaplan DL. 2017. Fabrication of elastomeric silk fibers. Bioploymers Epub ahead of print.  books

Liu Y, Zheng Z, Gong H, Liu M, Guo S, Li G, Wang X, Kaplan DL. 2017. DNA preservation in silk. Biomater Sic. Epub ahead of print. books

Ding X, Yang G, Zhang W, Li G, Lin S, Kaplan DL, Jiang X. 2017. Increased stem cells delivered using a silk gel/scaffold complex for enhanced bone regeneration. Sci Rep. 7: 2175. books

Li D, Jacobsen M, Rim N, Backman D, Kaplan D, Wong JY 2017. Introducing biomimetic shear and ion gradients to microfluidic spinning improves silk fiber strength. Biofabrication Epub ahead of print. books

Abbonante V, Di Buduo CA, Gruppi C, De Maria C, Spedden E, De Acutis A, Staii C, Raspanti M, Vozzi G, Kaplan D, Moccia F, Ravid K, Balduini A. 2017. A new path to platelet production through matrix sensing. Haematologica Epub ahead of print. books

Thurber AE, Nelson M, Frost CL, Levin M, Brackenbury WJ, Kaplan DL. 2017. IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines. Oncotarget Epub ahead of print.  books

Cebe P, Partlow BP, Kaplan DL, Wurm A, Zhuravlev E, Schick C. 2017. Silk I and silk II studied by fast scanning calorimetry. Acta Biomater. Epub ahead of print.  books

Landry MJ, Applegate MB, Bushuyev OS, Omenetto FG, Kaplan DL, Cronin-Golomb M, Barrett CJ. 2017. Photo-induced structural modification of silk gels containing azobenzene side groups. Soft Metter. Epub ahead of print. books

Raia NR, Partlow BP, McGill M, Kimmerling EP, Ghezzi CE, Kaplan DL. 2017. Enzymatically crosslinked silk-hyaluronic acid hydrogels. Biomaterials 131: 58-67. books

Tarakanova A, Huang W, Weiss AS, Kaplan DL, Buehler MJ. 2017. Computational smart polymer design based on elastin protein mutability. Biomaterials 127: 49-60.  books

Tseng P, Napier B, Zhao S, Mitropoulos AN, Applegate MB, Marelli B, Kaplan DL, Omenetto FG. 2017. Directed assembly of bio-inspired hierarchical materials with controlled nanofibrillar architectures. Nat Nanotechnol. Epub ahead of print. books

Huang W, Ebrahimi D, Dinjaski N, Tarakanova A, Buehler MJ, Wong JY, Kaplan DL. 2017. Synergistic integration of experimental and simulation approaches for the de novo design of silk-based materials. Ass Chem Res. Epub ahead of print.  books

Yang L, Zheng Z, Qian C, Wu J, Liu Y, Guo S, Li G, Liu M, Wang X, Kaplan DL. 2017. Curcumin-functionalized silk biomaterials for anti-aging utility. J Colloid Interface Sci. 496: 66-77.  books

Ghezzi CE, Marelli B, Omenetto FG, Funderburgh JL, Kaplan DL. 2017. 3D functional corneal stromal tissue equivalent based on corneal stromal stem cells and multi-layered silk film architecture. PLoS One 12: e0169504.  books

DeCicco RePass MA, Chen Y, Lin Y, Zhou W, Kaplan DL, Ward HD. 2017. A novel bioengineered 3D human intestinal model for long-term infection of Cryptosporidium parvum. Infect Immun. Epub ahead of print. books

Marelli B, Patel N, Duggan T, Perotto G, Shirman E, Li C, Kaplan DL, Omenetto FG. 2016. Programming function into mechanical forms by directed assembly of silk bulk materials. Proc Natl Acad Sci USA Epub ahead of print. Abstract in PubMed

Li C, Kilpatrick CD, Kenwood SS, Glettig DL, Glod DJ, Mallette J, Strunk MR, Chang J, Angle SR, Kaplan DL. 2017. Assessment of multipotent mesenchymal stromal cells in bone marrow aspirate from human calcaneus. J Foot Ankle Surg. 56: 42-56. Abstract in PubMed

Dinjaski N, Ebrahimi D, Qin Z, Giordano JE, Ling S, Buehler J M, Kaplan DL. 2016. Predicting rates of in vivo degradation of recombinant spider silk proteins. J Tissue Eng Regen Med. Epub ahead of print.  Abstract in PubMed

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I. 2016. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials 116: 34-47.  Abstract in PubMed

Brown JE, Moreau JE, Berman AM, McSherry HJ, Coburn JM, Schmidt DF, Kaplan DL. 2016. Shape memory silk protein sponges for minimally invasive tissue regeneration. Adv Healthc Mater. Epub ahead of print. Abstract in PubMed

Wang RY, Abbott RD, Zieba A, Borowsky FE, Kaplan DL. 2016. Development of a three-dimensional adipose tissue model for studying embryonic exposures to obesogenic chemicals. Ann Biomed Eng. Epub ahead of print. Abstract in PubMed

He M, Storr-Paulsen T, Wang AL, Ghezzi CE, Wang S, Fullana M, Karamichos D, Utheim TP, Islam R, Griffith M, Islam MM, Hodges RR, Wnek GE, Kaplan DL, Dartt DA. 2016. Artificial polymeric xcaffolds as extracellular matrix substitutes for autologous conjunctival goblet cell expansion. Invest Opthalmol Vis Sci. 57: 6134-6146. Abstract in PubMed

Dadwal U, Falank C, Fairfield H, Linehan S, Rosen CJ, Kaplan DL, Sterling J, Reagan MR. 2016. Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols. Bonekey Rep. 5:842.  Abstract in PubMed

Kumar M, Coburn J, Kaplan DL, Mandal BB. 2016. Immuno-informed 3D silk biomaterials for tailoring biological responses. ACS Appl Mater Interfaces 8: 29310-29322.  Abstract in PubMed

Coburn J, Harris J, Zakharov AD, Poirier J, Ikegaki N, Kajdacsy-Balla A, Pilichowska M, Lyubimov AV, Shimada H, Kaplan DL, Chiu B. 2016. Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment. Int J Cancer Epub ahead of print.  Abstract in PubMed

Pereira AM, Machado R, da Costa A, Ribeiro A, Collins T, Gomes AC, Leonor IB, Kaplan DL, Reis RL, Casal M. 2016. Silk-based biomaterials functionalized with fibronectin type II promotes cell adhesion. Acta Biomater. Epub ahead of print. Abstract in PubMed

Wang S, Ghezzi CE, Gomes R, Pollard RE, Funderburgh JL, Kaplan DL. 2016. In vitro 3D corneal tissue model with epithelium, stroma, and innervation. Biomaterials 9: 1-9. Abstract in PubMed

Milan PB, Lotfibakhshaiesh N, Joghataie MT, Ai J, Pazouki A, Kaplan DL, Kargozar S, Amini N, Hamblin MR, Mozafari M, Samadikuchaksaraei A. 2016. Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomater. 45: 234-246. Abstract in PubMed

Teuschl AH, Zipperle J, Huber-Gries C, Kaplan DL. 2016. Silk fibroin based carrier system for delivery of fibrinogen and thrombin as coagulant supplements. J Biomed Mater Res A Epub ahead of print. Abstract in PubMed

Li C, Hotz B, Ling S, Guo J, Haas DS, Marelli B, Omenetto F, Lin SJ, Kaplan DL. 2016. Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing. Biomaterials 110: 24-33. Abstract in PubMed

Harris JC, Coburn JM, Kajdacsy-Balla A, Kaplan DL, Chiu B. 2016. Sustained delivery of vincristine inside an orthotopic mouse sarcoma model decreases tumor growth. J Pediatr Surg. Epub ahead of print. Abstract in PubMed

Brouki Milan P, Lotfibakhshaiesh N, Joghataie MT, Ai J, Pazouki A, Kaplan DL, Kargozar S, Amini N, Hamblin MR, Mozafari M, Samadikuchaksaraei A. 2016. Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomater. Epub ahead of print. Abstract in PubMed

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL. 2016. Expandable and rapidly differentiating human induced neural stem cell lines for multiple tissue Engineering applications. Stem Cell Rep. Epub ahead of print. Abstract in PubMed

Zhang Q, Yan S, You R, Kaplan DL, Liu Y, Qu J, Li X, Li M, Wang X. 2016. Multichannel silk protein/laminin grafts for spinal cord injury repair. J Biomed Mater Res A 104: 3045-3057.  Abstract in PubMed

Stoppel WL, Gao AE, Greaney AM, Partlow BP, Bretherton RC, Kaplan DL, Black LD 3rd. 2016. Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response. J Biomed Mater Res A 104: 3058-3072.  Abstract in PubMed

Yigit S, Yu H, An B, Hamaia S, Farndale RW, Kaplan DL, Lin YS, Brodsky B. 2016. Mapping the effect of Gly mutations in collagen on α2β1 integrin binding. J Biol Chem. Epub ahead of print. 

Ding ZZ, Fan ZH, Huang XW, Bai SM, Song DW, Lu Q, Kaplan DL. 2016. Bioactive natural protein-hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells. J Mater Chem B Mater Biol Med. 4: 3555-3561. Abstract in PubMed

Yigit S, Yu H, An B, Hamaia S, Farndale RW, Kaplan DL, Lin YS, Brodsky B. 2016. Mapping the effect of Gly mutations in collagen on α2β1 integrin binding. J Biol Chem. Epub ahead of print. Abstract in PubMed

Sundarakrishnan A, Acero EH, Coburn J, Chwalek K, Partlow B, Kaplan DL. 2016. Phenol red-silk tyrosine cross-linked hydrogels. Acta Biomater. Epub ahead of print.  Abstract in PubMed

Ling S, Li C, Jin K, Kaplan DL, Buehler MJ. 2016. Liquid Exfoliated natural silk nanofibrils: Applications in optical and electrical devices. Adv Mater. Eupb ahead of print.  Abstract in PubMed

Han H, Ning H, Liu S, Lu Q Prof, Fan Z, Lu H, Lu G, Kaplan DL. 2016. Silk biomaterials with vascularization capacity. Adv Funct Mater. 26: 421-436.  Abstract in PubMed

Zheng Z, Guo S, Liu Y, Wu J, Li G, Liu M, Wang X, Kaplan D. 2016. Lithium-free processing of silk fibroin. J Biomater Appl. Epub ahead of print. Abstract in PubMed

Burke KA, Brenckle MA, Kaplan DL, Omenetto FG. 2016. Evaluation of the spectral response of functionalized silk inverse opals as colorimetric immunosensors. ACS Appl Mater Interfaces. Epub ahead of print.  Abstract in PubMed

Golding A, Guay JA, Herrera-Rincon C, Levin M, Kaplan DL. 2016. A tunable silk hydrogel device for studying limb regeneration in adult Xenopus laevis. PLoS One 11: e0155618.  Abstract in PubMed

Ghezzi CE, Wang L, Behlau I, Rnjak-Kovacina J, Wang S, Goldstein MH, Liu J, Marchant JK, Rosenblatt MI, Kaplan DL. 2016. Degradation of silk films in multipocket corneal stromal rabbit models. J Appl Biomater Funct Mater. Epub ahead of print. Abstract in PubMed

Wu J, Zheng Z, Li G, Kaplan DL, Wang X. 2016. Control of silk microsphere formation using polyethylene glycol (PEG). Acta Biomater. Epub ahead of print. Abstract in PubMed

Abbott RD, Wang RY, Reagan MR, Chen Y, Borowsky FE, Zieba A, Marra KG, Rubin JP, Ghobrial IM, Kaplan DL. 2016. The use of silk as a scaffold for mature, sustainable unilocular adipose 3D tissue engineered systems. Adv Healthc Mater. Epub ahead of print. Abstract in PubMed

Kluge JA, Li AB, Kahn BT, Michaud DS, Omenetto FG, Kaplan DL. 2016. Silk-based blood stabilization for diagnostics. Proc Natl Acad Sci USA Epub ahead of print. Abstract in PubMed

Stoichevska V, An B, Peng YY, Yigit S, Vashi AV, Kaplan DL, Werkmeister JA, Dumsday GJ, Ramshaw JA. 2016. Formation of multimers of bacterial collagens through introduction of specific sites for oxidative cross-linking. J Biomed Mater Res A Epub ahead of print. Abstract in PubMed

Marelli B, Brenckle MA, Kaplan DL, Omenetto FG. 2016. Silk fibroin as edible coating for perishable food preservation. Sci Rep. 6: 25623. Abstract in PubMed

Koolen PG, Haas D, Kim K, Fox S, Ibrahim AM, Kim P, Kaplan DL, Lin SJ. 2016. Increased osteoid formation in BMP-2-loaded silk-based screws. Plast Reconstr Surg. 137: 808e-817e. Abstract in PubMed

Calabrese R, Raia N, Huang W, Ghezzi CE, Simon M, Staii C, Weiss AS, Kaplan DL. 2016. Silk-ionomer and silk-tropoelastin hydrogels as charged three-dimensional culture platforms for the regulation of hMSC response. J Tissue Eng Regen Med. Epub ahead of print. Abstract in PubMed

Zhao S, Chen Y, Partlow BP, Golding AS, Tseng P, Coburn J, Applegate MB, Moreau JE, Omenetto FG, Kaplan DL. 2016. Bio-functionalized silk hydrogel microfluidic systems. Biomaterials 93: 60-70. books

Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, Kaplan DL, Omenetto FG. 2016. Silk fibroin: Photocrosslinking of silk fibroin using riboflavin for ocular prostheses. Adv Mater. 28: 2464. books

Plowright R, Dinjaski N, Zhou S, Belton DJ, Kaplan DL, Perry CC. 2016. Influence of silk-silica fusion protein design on silica condensation in vitro and cellular calcification. RSC Adv. 6: 21776-21788. books

Frazier TP, Bowles A, Lee S, Abbott R, Tucker HA, Kaplan D, Wang M, Strong A, Brown Q, He J, Bunnell BA, Gimble JM. 2016. Serially transplanted non-pericytic CD146- adipose stromal/stem cells in silk bioscaffolds regenerate adipose tissue in vivo. Stem Cells 34: 1097-1111. books

Li C, Levin M, Kaplan DL. 2016. Bioelectric modulation of macrophage polarization. Sci Rep. 6: 21004. books

Abbott RD, Kimmerling EP, Cairns DM, Kaplan DL. 2016. Silk as a biomaterial to support long-term three-dimensional tissue cultures. ACS Appl Mater Interfaces Epub ahead of print. books

Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, Kaplan DL, Omenetto FG. 2016. Photocrosslinking of silk fibroin using riboflavin for ccular prostheses. Adv Mater. 28: 2417-2420. books

Belanger K, Dinis TM, Taourirt S, Vidal G, Kaplan DL, Egles C. 2016. Recent strategies in tissue engineering for guided peripheral nerve regeneration. Macromol Biosci. 16: 472-481. books

Partlow BP, Tabatabai AP, Leisk GG, Cebe P, Blair DL, Kaplan DL. 2016. Silk fibroin degradation related to rheological and mechanical properties. Macromol Biosci. Epub ahead of print. books

Dinjaski N, Kaplan DL. 2015. Recombinant protein blends: Silk beyond natural design. Curr Opin Biotechnol. 39: 1-7. books

Liu SS, Liu LJ, Xiao LY, Lu Q, Zhu HS, Kaplan DL. 2015. Design of silk-vaterite microsphere systems as drug carriers with pH-responsive release behavior. J Mater Chem B Mater Biol Med. 3: 8314-8320. books

An B, Abbonante V, Xu H, Gavriilidou D, Yoshizumi A, Bihan D, Farndale RW, Kaplan DL, Balduini A, Leitinger B, Brodsky B. 2015. Recombinant collagen engineered to bind to discoidin domain receptors functions as a receptor inhibitor. J Biol Chem. Epub ahead of print. books

Sundelacruz S, Levin M, Kaplan DL. 2015. Comparison of the depolarization response of human mesenchymal stem cells from different donors. Sci Rep. 5: 18279. books

Burke KA, Roberts DC, Kaplan DL. 2015. Silk fibroin aqueous-based adhesives inspired by mussel adhesive proteins. Biomacromolecules Epub ahead of print. books

Applegate MB, Perotto G, Kaplan DL, Omenetto FG. 2015. Biocompatible silk step-index optical waveguides. Biomed Opt Express 6: 4221-4227. books

Pang J, Özkucur N, Ren M, Kaplan DL, Levin M, Miller EL. 2015. Automatic neuron segmentation and neural network analysis method for phase contrast microscopy images. Biomed Opt Express 6: 4395-4416. books

Elia R, Guo J, Budijono S, Normand V, Benczédi D, Omenetto F, Kaplan DL. 2015. Encapsulation of volatile compounds in silk microparticles. J Coat Technol Res. 12: 793-799. books

Chwalek K, Sood D, Cantley WL, White JD, Tang-Schomer M, Kaplan DL. 2015. Engineered 3D silk-collagen-based model of polarized neural tissue. J Vis Exp. Oct 23; (105). books

Coburn JM, Na E, Kaplan DL. 2015. Modulation of vincristine and doxorubicin binding and release from silk films. J Control Release 220: 229-239.  books

Samal SK, Goranov V, Dash M, Russo A, Shelyakova T, Graziosi P, Lungaro L, Riminucci A, Uhlarz M, Bañobre-López M, Rivas J, Herrmannsdörfer T, Rajadas J, De Smedt S, Braeckmans K, Kaplan DL, Dediu VA. 2015. Multilayered magnetic gelatin membrane scaffolds. ACS Appl Mater Interfaces 7: 23098-23109.  books

Perotto G, Cittadini M, Tao H, Kim S, Yang M, Kaplan DL, Martucci A, Omenetto FG 2015. Fabrication of tunable, high-refractive-index titanate-silk nanocomposites on the micro- and nanoscale. Adv Mater. 27: 6728-6732.   books

Hardy JG, Khaing ZZ, Xin S, Tien LW, Ghezzi CE, Mouser DJ, Sukhavasi RC, Preda RC, Gil ES, Kaplan DL, Schmidt CE. Into the groove: instructive silk-polypyrrole films with topographical guidance cues direct DRG neurite outgrowth. J Biomater Sci Polym Ed. 28:1-16.   books

Çakmak AS, Çakmak S, White JD, Raja WK, Kim K, Yiğit S, Kaplan DL, Gümüşderelioğlu M. 2015. Synergistic effect of exogeneous and endogeneous electrostimulation on osteogenic differentiation of human mesenchymal stem cells seeded on silk scaffolds. J Orthop Res. 34: 581-590.  books

Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL. 2015. Controlled release of cytokines using silk-biomaterials for macrophage polarization. Biomaterials 73:272-283.   books

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL. 2015. Non-invasive Assessments of Adipose Tissue Metabolism In Vitro. Ann Biomed Eng. 44: 725-732.   books

Li AB, Kluge JA, Guziewicz NA, Omenetto FG, Kaplan DL. 2015. Silk-based stabilization of biomacromolecules. J Control Release 219: 416-430.   books

Domigan LJ, Andersson M, Alberti KA, Chesler M, Xu Q, Johansson J, Rising A, Kaplan DL. 2015. Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands. Insect Biochem Mol Biol. 65: 100-106.   books

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL 2015. Robust bioengineered 3D functional human intestinal epithelium. Sci Rep. 5: 13708.   books

Applegate MB, Coburn J, Partlow BP, Moreau JE, Mondia JP, Marelli B, Kaplan DL, Omenetto FG. 2015. Laser-based three-dimensional multiscale micropatterning of biocompatible hydrogels for customized tissue engineering scaffolds. Proc Natl Acad Sci USA 112: 12052-12057.   books

Hardy JG, Ghezzi CE, Saballos RJ, Kaplan DL, Schmidt CE. 2015. Supracolloidal assemblies as sacrificial templates for porous silk-based biomaterials. Int J Mol Sci.16: 20511-20522.   books

Balduini A, Di Buduo CA, Kaplan DL. 2015. Translational approaches to functional platelet production ex vivo. Thromb Haemost. 115: 250-256.   books

Brown JE, Partlow BP, Berman AM, House MD, Kaplan DL. 2015. Injectable silk-based biomaterials for cervical tissue augmentation: An in vitro study. Am J Obstet Gynecol. 214: 118.e1-9.   books

Thurber AE, Omenetto FG, Kaplan DL. 2015. In vivo bioresponses to silk proteins. Biomaterials 71: 145-157.   books

Yigit S, Dinjaski N, Kaplan DL. 2015. Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications. Biotechnol Bioeng. 113: 913-929.   books

Kim DW, Lee OJ, Kim SW, Ki CS, Chao JR, Yoo H, Yoon SI, Lee JE, Park YR, Kweon H, Lee KG, Kaplan DL, Park CH. 2015. Novel fabrication of fluorescent silk utilized in biotechnological and medical applications. Biomaterials 70: 48-56.   books

Zheng ZZ, Liu M, Guo SZ, Wu JB, Lu DS, Li G, Liu SS, Wang XQ, Kaplan DL. 2015. Incorporation of quantum dots in silk biomaterials for fluorescence imaging. 3: 6509-6515.   books

Chwalek K, Tang-Schomer MD, Omenetto FG, Kaplan DL. 2015. In vitro bioengineered model of cortical brain tissue. Nat Protoc. 10: 1362-1372.  books

Stoppel WL, Kaplan DL, Black LD 3rd. 2015. Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev. 96: 135-155.   books

Tao H, Marelli B, Yang M, An B, Onses MS, Rogers JA, Kaplan DL, Omenetto FG. 2015. Inkjet printing: Inkjet printing of regenerated silk fibroin: From printable forms to printable functions. Adv Mater. 27: 4245.  books

Li JJ, Roohani-Esfahani SI, Kim K, Kaplan DL, Zreiqat H. 2015. Silk coating on a bioactive ceramic scaffold for bone regeneration: effective enhancement of mechanical and in vitro osteogenic properties towards load-bearing applications. J Tissue Eng Regen Med. Epub ahead of print.  books

Lobikin M, Paré JF, Kaplan DL, Levin M. 2015. Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in Xenopus laevis embryos. Int J Dev Biol. 59: 303-311.  books

Li JJ, Kim K, Roohani-Esfahani SI, Guo J, Kaplan DL, Zreiqat H. 2015. A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration. J Mater Chem B Mater Biol Med. 3 : 5361-5376. books

Hardy JG, Villancio-Wolter MK, Sukhavasi RC, Mouser DJ, Aguilar D Jr, Geissler SA, Kaplan DL, Schmidt CE. 2015. Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation toward osteogenic outcomes. Macromol Rapid Commun. Epub ahead of print. books

Tao H, Marelli B, Yang M, An B, Onses S, Rogers JA, Kaplan DL, Omenetto FG. 2015. Inkjet printing of regenerated silk fibroin: From printable forms to printable functions. Adv Mater. 27: 4273-4279. books

Hardy JG, Geissler SA, Aguilar D Jr, Villancio-Wolter MK, Mouser DJ, Sukhavasi RC, Cornelison RC, Tien LW, Preda RC, Hayden RS, Chow JK, Nguy L, Kaplan DL, Schmidt CE. 2015. Instructive conductive 3D silk foam-based bone tissue scaffolds enable electrical stimulation of stem cells for enhanced osteogenic differentiation. Macromol Biosci. 15: 1490-1496. books

Lin S, Ryu S, Tokareva O, Gronau G, Jacobsen MM, Huang W, Rizzo DJ, Li D, Staii C, Pugno NM, Wong JY, Kaplan DL, Buehler MJ. 2015. Predictive modelling-based design and experiments for synthesis and spinning of bioinspired silk fibres. Nat Comm. 6: 6892. books

Rnjak-Kovacina J, Wray LS, Burke KA, Torregrosa T, Golinski JM, Huang W, Kaplan DL. 2015. Lyophilized silk sponges: A versatile biomaterial platform for soft tissue engineering. ACS Biomater Sci Eng. 1 :260-270. books

Cho SY, Yun YS, Lee S, Jang D, Park KY, Kim JK, Kim BH, Kang K, Kaplan DL, Jin HJ. 2015. Carbonization of a stable β-sheet-rich silk protein into a pseudographitic pyroprotein.Nat Commun. 6: 7145. books

Zhang W, Wray LS, Rnjak-Kovacina J, Xu L, Zou D, Wang S, Zhang M, Dong J, Li G, Kaplan DL, Jiang X. 2015. Biomaterials 56: 68-77. books

Abbott RD, Kaplan DL. 2015. Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol. 33: 401-407. books

Han Q, Yang P, Wu Y, Meng S, Sui L, Zhang L, Yu L, Tang Y, Jiang H, Xuan D, Kaplan DL PhD, Kim SH, Tu Q, Chen J. 2015. Epigenetically modified bone marrow stromal cells (BMSCs) in silk scaffolds promote craniofacial bone repair and wound healing. Tissue Eng Part A 21: 2156-2165. books

Algarrahi K, Franck D, Ghezzi CE, Cristofaro V, Yang X, Sullivan MP, Chung YG, Affas S, Jennings R, Kaplan DL, Estrada CR Jr, Mauney JR. 2015. Acellular bi-layer silk fibroin scaffolds support functional tissue regeneration in a rat model of onlay esophagoplasty. Biomaterials 53: 149-159. books

Jia L, Ghezzi CE, Kaplan DL. 2015. Optimization of silk films as substrate for functional corneal epithelium growth. J Biomed Mater Res B Appl Biomater. 104: 431-441. books

Seib FP, Coburn J, Konrad I, Klebanov N, Jones GT, Blackwood B, Charest A, Kaplan DL, Chiu B. 2015. Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo. Acta Biomater. 20: 32-38. books

Abbott RD, Raja WK, Wang RY, Stinson JA, Glettig DL, Burke KA, Kaplan DL. 2015. Long term perfusion system supporting adipogenesis. Methods 84: 84-89. books

Bai S, Han H, Huang X, Xu W, Kaplan DL, Zhu H, Lu Q. 2015. Silk scaffolds with tunable mechanical capability for cell differentiation. Acta Biomater. 20: 22-31. books

Lin Y, Wang S, Chen Y, Wang Q, Burke KA, Spedden EM, Staii C, Weiss AS, Kaplan DL. 2015. Electrodeposited gels prepared from protein alloys. Nanomedicine (London) 5: 803-814. books

Stoppel WL, Hu D, Domian IJ, Kaplan DL, Black LD. 2015. Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering. Biomed Mater. 10: 034105. books

Wang S, Ghezzi CE, White JD, Kaplan DL. 2015. Co-culture of dorsal root ganglion neurons and differentiated human corneal stromal stem cells on silk-based scaffolds. J Biomed Mat Res A 103: 3339-3348. books

Seib FP, Berry JE, Shiozawa Y, Taichman RS, Kaplan DL 2015. Tissue engineering a surrogate niche for metastatic cancer cells. Biomaterials 51: 313-319. books

DesRochers TM, Kuo IY, Kimmerling EP, Ehrlich BE, Kaplan DL. 2015. The effects of mycoplasma contamination upon the ability to form bioengineered 3D kidney cysts. PLoS One 10: e0120097. books

Rnjak-Kovacina J, DesRochers TM, Burke KA, Kaplan DL. 2015. The effect of sterilization on silk fibroin biomaterial properties. Macromol Biosci. 15: 861-874. books

Mwangi TK, Bowles RD, Tainter DM, Bell RD, Kaplan DL, Setton LA. 2015. Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery. Int J Pharm. 485: 7-14. books

An B, Tang-Schomer MD, Huang W, He J, Jones JA, Lewis RV, Kaplan DL. 2015. Physical and biological regulation of neuron regenerative growth and network formation on recombinant dragline silks. Biomaterials 48: 137-146. books

Di Buduo CA, Wray LS, Tozzi L, Malara A, Chen Y, Ghezzi CE, Smoot D, Sfara C, Antonelli A, Spedden E, Bruni G, Staii C, De Marco L, Magnani M, Kaplan DL, Balduini A. 2015. Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies. Blood 125: 2254-2264. books

Lovett ML, Wang X, Yucel T, York L, Keirstead M, Haggerty L, Kaplan DL. 2015. Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics. Eur J Pharm Biopharm. 95: 271-278. books

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research