Recent Publications from the Jaffe Lab

Research Publications Cell Biology


Davel AP, Lu Q, Moss ME, Rao S, Anwar IJ, DuPont JJ, Jaffe IZ. 2018. J Am Heart Assoc 7: pii: e007675. doi: 10.1161/JAHA.117.007675. books

Kim SK, McCurley AT, DuPont JJ, Aronovitz M, Moss ME, Stillman IE, Karumanchi SA, Christou DD, Jaffe IZ. 2018. Smooth muscle cell-mineralocorticoid receptor as a mediator of cardiovascular stiffness with aging. Hypertension Epub ahead of print. books

Diaz-Otero JM, Fisher C, Downs K, Moss ME, Jaffe IZ, Jackson WF, Dorrance AM. 2017. Endothelial mineralocorticoid receptor mediates parenchymal arteriole and posterior cerebral artery remodeling during angiotensin II-induced hypertension. Hypertension 70: 1113-1121.  books

Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P. 2017. Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation. Physiol Rep. 5 (12).  books

Marzolla V, Armani A, Mammi C, Moss ME, Pagliarini V, Pontecorvo L, Antelmi A, Fabbri A, Rosano G, Jaffe IZ, Caprio M. 2017. Essential role of ICAM-1 in aldosterone-induced atherosclerosis. Int J Cardiol. Epub ahead of print.  Abstract in PubMed

Davel AP, Anwar IJ, Jaffe IZ. 2016. The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. Curr Opin Nephrol Hypertens. Epub ahead of print.  books

Lu Q, Schnitzler GR, Vallaster CS, Ueda K, Erdkamp S, Briggs CE, Iyer LK, Jaffe IZ, Karas RH. 2016. Unliganded estrogen receptor alpha regulates vascular cell function and gene expression. mol Cell Endocrinol. Epub ahead of print.  books

DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo JK, Aronovitz M, Baur WE, Christou DD, Hill MA, Jaffe IZ. 2016. Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. JCI Ingsiht 1: e88942.  books

Gopal S, Miller KB, Jaffe IZ. 2016. Molecular mechanisms for vascular complications of targeted cancer therapies. Clin Sci. 130: 1763-1779. books

Victorio JA, Clerici SP, Palacios R, Alonso MJ, Vassallo DV, Jaffe IZ, Rossoni LV, Davel AP. 2016. Spironolactone prevents endothelial nitric oxide synthase uncoupling and vascular dysfunction induced by β-adrenergic overstimulation: Role of perivascular adipose tissue. Hypertension Epub ahead of print.  books

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P. 2016. Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling, and function in pressure overload-induced heart failure. J Am Heart Assoc. pii: e003126.  books

Jia G, Habibi J, Aroor AR, Martinez-Lemus LA, DeMarco VG, Ramirez-Perez FI, Sun Z, Hayden MR, Meininger GA, Barrett Mueller KV, Jaffe IZ, Sowers JR. 2016. Endothelial mineralocorticoid receptor mediates diet induced aortic stiffness in females. Circ Res. 118: 935-943. books

Morine KJ, Paruchuri V, Qiao X, Mohammad N, Mcgraw A, Yunis A, Jaffe I, Kapur NK. 2015. Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis. Biomarkers 15: 1-7. books

Hwang MH, Yoo JK, Luttrell M, Kim HK, Meade TH, English M, Talcott S, Jaffe IZ, Christou DD 2015. Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults. Exp Gerontol. 73: 86-94. books

Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR. 2015. Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females. Hypertension Epub ahead of print. books

Moss ME, Jaffe IZ. 2015. Mineralocorticoid receptors in the pathophysiology of vascular inflammation and atherosclerosis. Front Endocrinol (Lausanne) 6: 153. books

Amador CA, Bertocchio JP, Andre-Gregoire G, Placier S, Duong Van Huyen JP, El Moghrabi S, Berger S, Warnock DG, Chatziantoniou C, Jaffe IZ, Rieu P, Jaisser F. 2015. Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration. Kidney Int. Epub ahead of print.  books

Mueller KB, Bender SB, Hong K, Yang Y, Aronovitz M, Jaisser F, Hill MA, Jaffe IZ. 2015. Endothelial mineralocorticoid receptors differentially contribute to coronary and mesenteric vascular function without modulating blood pressure. Hypertension 66: 988-997.  books

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. 2015. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension 65: 863-870. books

Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR. 2015. Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension 65: 1082-1088. books

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. 2015. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension 65: 863-870. books

Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ. 2014. Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function. Endocrinology 155: 4461-4472. books

Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH. 2014. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 3: e000965. books

DuPont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ. 2014. Aldosterone and vascular mineralocorticoid receptors: regulators of ion channels beyond the kidney. Hypertension 63: 632-637. books

Koenig JB, Jaffe IZ. 2014. Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications. Curr Hypertens Rep. 16: 427. books

Chen CW, Jaffe IZ, Karumanchi SA. 2014. Pre-eclampsia and cardiovascular disease. Cardiovasc Res. 101: 579-586. books

Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, Kang PM, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, Lely AT. 2014. Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor. J Am Soc Nephrol. 25: 717-725. books

Bene NC, Alcaide P, Wortis HH, Jaffe IZ. 2014. Mineralocorticoid receptors in immune cells: Emerging role in cardiovascular disease. Steroids 91: 38-45. books

Galmiche G, Pizard A, Gueret A, El Moghrabi S, Ouvrard-Pascaud A, Berger S, Challande P, Jaffe IZ, Labat C, Lacolley P, Jaisser F. 2014. Smooth muscle cell mineralocorticoid receptors are mandatory for aldosterone-salt to induce vascular stiffness. Hypertension 63: 520-526. books

Jaffe IZ, Jaisser F. 2014. Endothelial cell mineralocorticoid receptors: Turning cardiovascular risk factors into cardiovascular dysfunction. Hypertension 63: 915-917. books

Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ. 2014. Aldosterone promotes vascular remodeling by direct effects on smooth muscle C cell mineralocorticoid receptors. Arterioscler Thromb Vasc Biol. 34: 355-364. books

Barrett K, McCurley A, Jaffe IZ. 2013. Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation. Clin Exp Pharmacol Physiol. 40: 902-909. books

McGraw AP, McCurley A, Preston IR, Jaffe IZ. 2013. Mineralocorticoid receptors in vascular disease: connecting molecular pathways to clinical implications. Curr Artherscler Rep. 15: 340. books

McCurley A, McGraw A, Pruthi D, Jaffe IZ. 2013. Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease. Pflugers Arch. 465: 1661-1670. books

McGraw AP, Bagley J, Chen W-S, Galayda C, Nickerson H, Armani A, Caprio M, Carmeliet P, Jaffe IZ, 2013. Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. J Am Heart Assoc. 2: e000018. books

Preston IR, Sagliani KD, Warburton RR, Hill NS, Fanburg BL, Jaffe IZ. 2013. Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 304: L678-688. books

Bender SB, McGraw AP, Jaffe IZ, Sowers JR. 2013. Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes 62: 313-319. books

Ehsan A, McGraw AP, Aronovitz MJ, Galayda C, Conte MS, Karas RH, Jaffe IZ. 2012. Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice. J Thorac Cardiovasc Surg. 145: 1642-1649. books

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. 2012. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 18: 1429-1433. books

Kapur NK, Shenoy C, Yunis AA, Mohammad NN, Wilson S, Paruchuri V, Mackey EE, Qiao X, Shah A, Esposito ML, Karas RH, Jaffe IZ. 2012. Distinct effects of unfractionated heparin versus bivalirudin on circulating angiogenic peptides. PLoS One 7: e34344. books

McCurley A, Jaffe IZ. 2012. Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol. 350: 256-265. books

Newfell BG, Iyer LK, Mohammad NN, McGraw AP, Ehsan A, Rosano G, Huang PL, Mendelsohn ME, Jaffe IZ. 2011. Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways. Arterioscler Thromb Vasc Biol. 31: 1871-1880. books

Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. 2011. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 301: H41-47. books

Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME. 2010. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest. 120: 3891-3900. books

Caprio M, Mammi C, Jaffe IZ, Zennaro MC, Aversa A, Mendelsohn ME, Fabbri A, Rosano G. 2008. The mineralocorticoid receptor in endothelial physiology and disease: Novel concepts in the understanding of erectile dysfuction. Curr Pharm Des 14: 3749-3757.  books

Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME.  2008. Rapid recruitment of temporally distinct vascular gene sets by estrogen.  Mol Endocrinol. 22: 2544-2556.  books

Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ.  2008. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.  Circ Res. 102: 1359-1367.  books 

Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. 2007. Mineralcorticoid receptor activation promotes vascular cell calcification.  Aterioscler Thromb Vasc Biol. 27: 799-805. books

O’Lone R, Knorr K, Jaffe IZ, Schaffer M, Martini P, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U. 2007. Estrogen receptors α and β mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species.  Mol Endocrinol. 21: 1281-1296.  books

Jaffe IZ, Mendelsohn ME.  2005. Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res. 96: 643-650.  books

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