Recent Publications from the Jacob Lab

Research Publications Cell Biology Neuroscience


Pirone A, Alexander J, Lau LA, Hampton D, Zayachkivsky A, Yee A, Yee A, Jacob MH, Dulla CG. 2016. APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures. Neurobiol Dis. Epub ahead of print.  Abstract in PubMed

Hickman TT, Liberman MC, Jacob MH. 2015. Adenomatous polyposis coli protein deletion in efferent olivocochlear neurons perturbs afferent synaptic maturation and reduces the dynamic range of hearing. J Neurosci. 35: 9236-9245. books

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. New molecular insights into cognitive and autistic-like disabilities. Mol Psychiatry 19: 1053. books

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. Mol Psychiatry 19: 133-142. books

Scholl ES, Pirone A, Cox DH, Duncan RK, Jacob MH. 2014. Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels. Channels (Austin). 8: 62-75. books

Rosenberg MM, Yang F, Mohn JL, Storer EK, Jacob MH. 2010. The postsynaptic APC multi-protein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. J Neurosci. 30: 11073-11085. books

Hone AJ, Whiteaker P, Mohn JL, Jacob MH, Michael McIntosh J. 2010. Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling α7 nicotinic acetylcholine receptors. J Neurosci. 114: 994-1006 books

Blitzblau R, Storer EK, Jacob MH. 2008. Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion. Brain Res. 1218: 21-34. books

Rosenberg M, Yang F, Giovanni M, Mohn J, Temburni MK, Jacob MH. 2008. Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Mol Cell Neurosci. 38: 138- 152. books 

Olsen D, Dunlap K, Jacob MH. 2007. Kainate receptors and RNA editing in cholinergic neurons. J Neurochem. 101: 327-341. books

Rassadi S, Krishnaswamy A, Pie B, McConnell R, Jacob MH, Cooper E. 2005 A null mutation for the a3 nicotinic acetlycholine (ACh) receptor gene abolishes fast synaptic activity in sympathetic ganglia and reveals that ACh output from developing preganglionic terminals is regulated in an activity-dependent retrograde manner. J Neurosci. 25: 8555-8566. books 

Temburni MK, Rosenberg M, Pathak N, McConnell R, Jacob MH. 2004. Neuronal nicotinic synapse synapse assembly requires the adenomatous polyposis coli tumor suppressor protein. J Neurosci. 24: 6776-6784. books 

Tosetti P, Pathak N, Jacob MH, Dunlap K. 2003.  RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons. Proc Natl Acad Sci USA 100: 7337-7342. books

Wong EV, David S, Jacob MH, Jay DG. 2003. Inactivation of myelin-associated glycoprotein (MAG) enhances optic nerve regeneration. J Neurosci. 23:3112-3117. books

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research