Recent Publications from the Imanishi-Kari Lab

Research Publications Genetics Immunology


McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T. 2017. Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genes. Front Immunol. 8: 1094. books

McDonald G, Cabal N, Vannier A, Umiker B, Yin RH, Orjalo AV Jr, Johansson HE, Han JH, Imanishi-Kari T. 2015. Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked Toll-like receptor 8. Front Immunol. 6: 457. books

Umiker BR, McDonald G, Larbi A, Medina CO, Reth M, Imanishi-Kari T. 2014. Production of IgG autoantibody requires expression of activation-induced deaminase in early developing B cells in a mouse model of SLE. Eur J Immunol. 44: 3093-3108. books

Umiker BR, Andersson S, Fernandez L, Korgaokar P, Larbi A, Pilichowska M, Weinkauf CC, Wortis HH, Kearney JF, Imanishi-Kari T. 2014. Dosage of X-linked toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus. Eur J Immunol. 44: 1503-1516. books

Giltiay NV, Chappell CP, Sun X, Kolhatkar N, Teal TH, Wiedeman AE, Kim J, Tanaka L, Buechler MB, Hamerman JA, Imanishi-Kari T, Clark EA, Elkon KB. Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells. J Exp Med 210: 2773-2789. books

Han JH, Umiker BR, Kazimirova AA, Fray M, Korgaonkar P, Selsing E, Imanishi-Kari T. 2013. Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expression. Eur J Immunol. 44: 215-226. books

Han JH, Akira S, Calame K, Beutler B, Selsing E, Imanishi-Kari T. 2007. Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors. Immunity 27: 64-75. books

Berland R, Fernandez L, Kari E, Han J-H, Lomakin I, Akira S, Wortis HH, Kearney JF, Ucci AA, Imanishi-Kari T. 2006. TLR7-dependent loss of B cell tolerance in pathogenic autoantibody knock-in mice. Immunity 25: 429-440. books

Mao C, Jiang L, Melo-Jorge M, Puthenveetil M, Zhang X, Carroll MC, Imanishi-Kari T. 2004. T Cell-independent somatic hypermutation in murine B cells with an immature phenotype. Immunity 20: 133-144. books

Li J, Fernandez L, O'Connor KC, Imanishi-Kari T, Stollar BD. 2001. The rearranged V(H) domain of a physiologically selected anti-single-stranded DNA antidoby as a precursor for formation of IgM and IgG antibodies to diverse antigens. J Immunol 167: 3746-3755. books

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