Recent Publications from the Iacomini Lab

Research Publications  Cell Biology
Genetics Immunology


Benway CJ, Iacomini J. 2017. Defining a microRNA-mRNA interaction map for calcineurin inhibitor induced nephrotoxicity. Am J Transplant. Epub ahead of print. books

Riella LV, Bagley J, Iacomini J, Alegre ML. 2017. Impact of environmental factors on alloimmunity and transplant fate. J Clin Invest. 127: 2482-2491. books

Bagley J, Yuan J, Iacomini J. 2017. Impact of hyperlipidemia on alloimmunity. Curr Opin Organ Transplant. 22: 14-21. books

Yuan J, Bagley J, Iacomini J. 2015. Hyperlipidemia promotes anti-donor Th17 responses that accelerate allograft rejection. Am J Transplant. 15: 2336-2345. books

Kristian SA, Hwang JH, Hall B, Leire E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. 2015. Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer. J Mol Med. 93: 619-631. books

Bagley J, Yuan J, Chandrakar A, Iacomini J. 2015. Hyperlipidemia alters regulatory T cell function and promotes resistance to tolerance induction through costimulatory molecule blockade. Am J Transplant. 15: 2324-2335. books

Yuan J, Benway CJ, Bagley J, Iacomini J. 2015. MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Am J Transplant. 15: 1682-1691. books

Baranyi U, Gattringer M, Farkas AM, Hock K, Pilat N, Iacomini J, Valenta R, Wekerle T. 2013. The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism. Eur J Immunol. 43: 2451-2460. books

Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Buchberger E, Ramsey H, Iacomini J, Valenta R, Wekerle T. 2013. Engraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance. Immunobiology 218: 1139-1146. books

Jindra PT, Tripathi S, Tian C, Iacomini J, Bagley J. 2012. Tolerance to MHC class II disparate allografts through genetic modification of bone marrow. Gene Ther. 20: 478-486. books

Baranyi U, Pilat N, Gattringer M, Linhart B, Klaus C, Schwaiger E, Iacomini J, Valenta R, Wekerle T. 2012. Persistent molecular microchimerism induces long-term tolerance towards a clinically relevant respiratory allergen. Clin Exp Allergy. 42: 1282-1292. books

Zhao X, Boenisch O, Yeung M, Mfarrej B, Yang S, Turka LA, Sayegh MH, Iacomini J, Yuan X. 2012. Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance. Am J Transplant. 12: 90-101. books

Shapiro MD, Bagley J, Latz J, Godwin JG, Ge X, Tullius SG, Iacomini J.  2011. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One. 6: e23011. books

D'Addio F, Yuan X, Habicht A, Williams J, Ruzek M, Iacomini J, Turka LA, Sayegh MH, Najafian N, Ansari MJ. 2010. A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation 90: 260-269. books

Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, Iacomini J. 2010. Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci U S A. 107: 14339-14344. books

Jindra PT, Bagley J, Godwin JG, Iacomini J. 2010. Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten. J Immunol. 185: 990-997. books

Tian C, Yuan X, Jindra PT, Bagley J, Sayegh MH, Iacomini J. 2010. Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen. Clin Immunol. 136:174-187. books

Yuan X, Sayegh MH, Iacomini J. 2009. Understanding how Tregs are regulated: therapeutic implications. Transplantation 88: 1159-1160. books

Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH. 2009. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A. 106: 10734-10739. books

Bagley J, Paez-Cortez J, Tian C, Iacomini J. 2008. Gene therapy in type 1 diabetes. Crit Rev Immunol. 28: 301-324. books

Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH, Ansari MJ. 2008. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med. 205: 3133-3144. books

Bagley J, Tian C, Iacomini J. 2008. Prevention of type 1 diabetes in NOD mice by genetic engineering of hematopoietic stem cells. Methods Mol Biol. 433: 277-285. books

Paez-Cortez J, Montano R, Iacomini J, Cardier J. 2008. Liver sinusoidal endothelial cells as possible vehicles for gene therapy: a comparison between plasmid-based and lentiviral gene transfer techniques. Endothelium 15: 165-173. books

Baranyi U, Linhart B, Pilat N, Gattringer M, Bagley J, Muehlbacher F, Iacomini J, Valenta R, Wekerle T. 2008. Tolerization of a type I allergic immune response through transplantation of genetically modified hematopoietic stem cells. J Immunol. 180: 8168-8175. books

Benatuil L, Kaye J, Cretin N, Godwin JG, Cariappa A, Pillai S, Iacomini J. 2008. Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies. J Immunol. 180: 3839-3848. books

Tian C, Yuan X, Bagley J, Blazar BR, Sayegh MH, Iacomini J. 2008. Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells. Clin Immunol. 127: 130-137. books

Tian C, Ansari MJ, Paez-Cortez J, Bagley J, Godwin J, Donnarumma M, Sayegh MH, Iacomini J. 2007. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol. 179: 6762-6769. books

Bagley J, Tian C, Iacomini J. 2007. New approaches to the prevention of organ allograft rejection and tolerance induction. Transplantation 84: S38-41. books

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