Recent Publications from the Heldwein Lab

Research Publications Biochemistry Cell Biology Microbiology

 

Bigalke JM, Heldwein EE. 2017. Have NEC coat, will travel: Structural basis of membrane budding during nuclear egress in herpesviruses. Adv Virus Res. 97:107-141. books

Rogalin HB, Heldwein EE. 2016. Characterization of VSV pseudotypes bearing essential entry glycoproteins gB, gD, gH, and gL of Herpes Simplex virus Type 1. J Virol. Epub ahead of print. books

Biglake JM, Heldwein EE. 2016. Expression, purification and crystallization of the herpesvirus nuclear egress complex (NEC). Bio Protoc 6: e1872. books

Bigalke JM, Heldwein EE. 2016. Nuclear exodus: Herpesviruses lead the way. Annu Rev Virol. Epub ahead of print. books

Metrick CM, Heldwein EE. 2016. The novel structure and unexpected RNA-binding ability of the C-terminal domain of HSV-1 tegument protein UL21. J Virol. 90: 5759-69.  Erratum: J Virol. 90: 7007-7008. books

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. 2016. Data publication with the structural biology data grid supports live analysis. Nat Commun. 7: 10882.  books

Heldwein EE. 2016. gH/gL supercomplexes at early stages of herpesvirus entry. Curr Opin Virol. 18: 1-8. books

Cooper RS, Heldwein EE. 2015. Herpesvirus gB: A finely tuned fusion machine. Viruses 7: 6552-6569.  books

Bigalke JM, Heldwein EE. 2015. Structural basis of membrane budding by the nuclear egress complex of herpesviruses. EMBO J. 34: 2921-2936.  books

Burke HG, Heldwein EE 2015. Crystal structure of the human cytomegalovirus glycoprotein B. PLoS Pathog. 11: e1005227.  books

Rogalin HB, Heldwein EE. 2015. The interplay between the HSV-1 gB cytodomains and the gH cytotail during cell-cell fusion. J Virol. 89: 12262-12272. books

Bigalke JM, Heldwein EE. 2015. The great (nuclear) escape: new insights into the role of the nuclear egress complex of herpesviruses. J Virol. 89: 9150-9153. books

Metrick CM, Chadha P, Heldwein EE. 2014. The unusual fold of HSV-1 UL21, a multifunctional tegument protein. J Virol. 89: 2979-2984. books

Bigalke JM, Heuser T, Nicastro D, Heldwein EE. 2014. Membrane deformation and scission by the HSV-1 nuclear egress complex. Nat Commun. 5: 4131. books

Stampfer SD, Heldwein EE. Expression, purification, and crystallization of HSV-1 glycoproteins for dtructure determination. Methods Mol Biol. 1144: 249-263. books

Pitts JD, Klabis J, Richards AL, Smith GA, Heldwein EE. 2014. Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking. J Virol. 88: 5462-5473. books

Silverman JL, Heldwein EE. 2013. Mutations in the cytoplasmic tail of HSV-1 gH reduce the fusogenicity of gB in transfected cells. J Virol. 87: 10139-10147. books

Vitu E, Sharma S, Stampfer SD, Heldwein EE. 2013. Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form. J Mol Biol. 425: 2056-2071. books

Sharma S, Wisner TW, Johnson DC, Heldwein EE. 2013. HCMV gB shares structural and functional properties with gB proteins from other herpesviruses. Virology 435: 239-249. books

Stampfer SD, Heldwein EE. 2013. Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. Curr Opin Virol. 3: 13-19. books

Silverman JL, Greene NG, King DS, Heldwein EE. 2012. Membrane requirement for the folding of the HSV-1 gB cytodomain suggests a unique mechanism of fusion regulation. J Virol. 86: 8171-8174.  books

Cairns TM, Whitbeck JC, Lou H, Heldwein EE, Chowdary TK, Eisenberg RJ, Cohen GH. 2011. Capturing the herpes simplex virus core fusion complex (gB-gH/gL) in an acidic environment. J Virol. 85: 6175-6184. books

Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE. Structural basis of local, pH-dependent conformational changes in glycoprotein B from Herpes Simplex virus 1. J Virol 84: 12924-12933. books

Chowdary TK, Heldwein EE. 2010. Syncytial phenotype of C-terminally truncated herpes simplex virus type 1 gB is associated with diminished membrane interactions. J. Virol. 84: 4923-4935. Abstract in PubMed

Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE. 2010. Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL. Nat Struct Mol Biol. 17: 882-888. books

Silverman JL, Sharma S, Cairns TM, Heldwein EE. 2009. Fusion-null insertion mutants of HSV-1 gB adopt the trimeric postfusion conformation. J Virol. 84:2001-2012. Abstract in PubMed

Heldwein EE. 2009. Entry of herpesviruses into cells: more than one way to pull the trigger. Structure 17: 147-149. Abstract in PubMed

Heldwein EE, Krummenacher C. 2008. Entry of herpesviruses into mammalian cells. Cell Mol Life Sci. 65: 1653-1658.  books

Hannah BP, Heldwein EE, Bender FC, Cohen GH, Eisenberg RJ. 2007. Mutational Evidence of Internal Fusion Loops in HSV glycoprotein B. J Virol. 81: 4858-4865. books

Bender FC, Samanta M, Heldwein EE, deLeon, MP, Lou H, Bilman E, Whitbeck JC, Eisenberg RJ, Cohen GH. 2007. Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions. J Virol. 81: 3827-3841. books

Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC. 2006. Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313: 217-220. books

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