Recent Publications from the Haydon Lab

Research Publications Neuroscience


Papouin T, Haydon PG. 2018. D-serine measurements in brain slices or other tissue explants. Bio Protoc. 8 pii: e2698. Abstract in PubMed

Papouin T, Haydon PG. 2018. Obtaining acute brain slices.Bio Protoc. 8 pii: e2699. Abstract in PubMed

Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, Haydon PG, Tesco G. 2018. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 13: 6. Abstract in PubMed

Clasadonte J, Scemes E, Wang Z, Boison D, Haydon PG. 2017. Connexin 43-mediated astroglial metabolic networks contribute to the regulation of the sleep-wake cycle. Neuron 95: 1365-1380. Abstract in PubMed

Papouin T, Dunphy JM, Tolman M, Dineley KT, Haydon PG. 2017. Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness. Neuron Epub ahead of print. Abstract in PubMed

Haydon, PG. 2017. Astrocytes and the modulation of sleep. Curr Opin Neurobiol. 44:28-33. Abstract in PubMed

Foley J, Blutstein T, Lee S, Erneux C, Halassa MM, Haydon P. 2017. Astrocytic IP3/Ca2+ signaling modulates theta rhythm and REM sleep. Front Neural Circuits 11:3.  Abstract in PubMed

Papouin T, Dunphy J, Tolman M, Foley JC, Haydon PG. 2017. Astrocytic control of synaptic function. Philos Trans R Soc Lond B Biol Sci. 372 (1715). Abstract in PubMed

Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, Turrigiano GG, van Rossum MC. 2017. Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci. 372 (1715). Abstract in PubMed

Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G. 2016. Genetic deletion of the clathrin adaptor GGA3 reduces anxiety and alters GABAergic transmission. PLoS One 11: e0155799. Abstract in PubMed

Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiol Dis. Epub ahead of print. books

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.  books

Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW. 2015. Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking. Biol Psychiatry 78: 441-451. books

Haydon PG, Nedergaard M. 2014. How do astrocytes participate in neural plasticity? Cold Spring Harb Perspect Biol. 7: a020438. books

Clasadonte J, Haydon PG. 2014. Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function. Neurosci Bull. 30: 1045-1048. books

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. New molecular insights into cognitive and autistic-like disabilities. Mol Psychiatry 19: 1053. books

Terunuma M, Haydon PG, Pangalos MN, Moss SJ. 2014. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Neuropharmacology 88: 74-81. books

Hines DJ, Haydon PG. 2014. Astrocytic adenosine: from synapses to psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 369. books

Huyghe D, Nakamura Y, Terunuma M, Faideau M, Haydon P, Pangalos NM, Moss SJ. 2014. Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by G-aminobutyric type B receptors. J Biol Chem. 289: 28808-28815. books

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. Mol Psychiatry 19: 133-142. books

Araque A, Carmignoto G, Haydon PG, Oliet SH, Robitaille R, Volterra A. 2014. Gliotransmitters travel in time and space. Neuron 81: 728-739. Abstract in PubMed

Kawamata H, Ng SK, Diaz N, Burstein S, Morel L, Osgood A, Sider B, Higashimori H, Haydon PG, Manfredi G, Yang Y. 2014. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J Neurosci. 34: 2331-2348. Abstract in PubMed

Clasadonte J, McIver SR, Schmitt LI, Halassa MM, Haydon PG. 2014. Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci. 34: 1879-1891. books

Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ. 2014. Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. J Neurosci. 34: 804-816. books

Lalo U, Palygin O, Rasooli-Nejad S, Andrew J, Haydon PG, Pankratov Y. 2014. Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. PLoS Biol. 12: e1001747. books

Clasadonte J, Dong J, Hines DJ, Haydon PG 2013. Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy. Proc Natl Acad Sci USA 110: 17540-17545. books

Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ. 2013. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABAA-receptor γ2 subunit. J Neurosci. 39: 15567-15577. books

Hines RM, Hines DJ, Houston CM, Mukherjee J, Haydon PG, Tretter V, Smart TG, Moss SJ. 2013. Disrupting the clustering of GABAA receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficits. Proc Natl Acad Sci USA 100: 16628-16633. books

Hines DJ, Haydon PG. 2013. Inhibition of a SNARE-sensitive pathway in astrocytes attenuates damage following stroke. J Neurosci. 33:4234-4240. books

Nadjar A, Blutstein T, Aubert A, Laye S, Haydon PG. 2013. Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response. Glia 61: 724-731. books

Hines DJ, Schmitt LI, Hines RM, Moss SJ, Haydon PG. 2013. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry 15: e212. books

Choo AM, Miller WJ, Chen YC, Nibley P, Patel TP, Goletiani C, Morrison B 3rd, Kutzing MK, Firestein BL, Sul JY, Haydon PG, Meaney DF. 2013. Antagonism of purinergic signalling improves recovery from traumatic brain injury. Brain 136(Pt1): 65-80. books

Blutstein T, Haydon PG. 2013. The Importance of astrocyte-derived purines in the modulation of sleep. Glia 61: 129-139. books

Turner JR, Ecke LE, Briand LA, Haydon PG, Blendy JA. 2013. Cocaine-related behaviors in mice with deficient gliotransmission. Psychopharmacology (Berlin) 226: 167-176. books

Clasadonte J, Haydon PG. 2012. Astrocytes and Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information. books

McIver SR, Muccigrosso MM, Haydon PG. 2012. The effect of doxycycline on alcohol consumption and sensitivity: consideration for inducible transgenic mouse models. Exp Biol Med. 237: 1129-1133. books

Schmitt LI, Sims RE, Dale N, Haydon PG. 2012. Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine. J Neurosci. 32: 4417-4425. books

Carmignoto G, Haydon PG. 2012. Astrocyte calcium signaling and epilepsy. Glia 60: 1227-1233. books

Zorec R, Araque A, Carmignoto G, Haydon PG, Verkhratsky A, Parpura V. 2012. Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route. ASN Neuro 4: e00080. books

Nam HW, McIver SR, Hinton DJ, Thakkar MM, Sari Y, Parkinson FE, Haydon PG, Choi DS. 2012. Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. Alcohol Clin Exp Res. 36: 1117-1125. books

Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout RF Jr, Spray DC, Reichenbach A, Pannicke T, Pekny M, Pekna M, Zorec R, Verkhratsky A. 2012. Glial cells in (patho)physiology. J Neurochem. 121: 4-27. books

Foley JC, McIver SR, Haydon PG. 2011. Gliotransmission modulates baseline mechanical nociception Mol Pain 7:93. books

Deng Q, Terunuma M, Fellin T, Moss SJ, Haydon PG. 2011. Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a Src kinase dependent pathway. Glia. 59: 1084-1093. books

Lee SY, Haydon PG. 2011. A cytokine-dependent switch for glial-neuron interactions. Neuron 69: 835-837. books

Halassa MM, Dal Maschio M, Beltramo R, Haydon PG, Benfenati F, Fellin T. 2010. Integrated brain circuits: neuron-astrocyte interaction in sleep-related rhythmogenesis. Scientific World J 17: 1634-1645. books

Ortinski PI, Dong J, Mungenast A, Yue C, Takano H, Watson DJ, Haydon PG, Coulter DA. 2010. Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nature Neurosci. 13: 584-591. books

Dong J, Revilla-Sanchez R, Moss S, Haydon PG. 2010. Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease. Neuropharmacology 59: 268-275. books

Halassa MM, Haydon PG. 2010. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol. 72: 335-355. books

Potokar M, Kreft M, Lee SY, Takano H, Haydon PG, Zorec R. 2009. Trafficking of astrocytic vesicles in hippocampal slices. Biochim Biophys Res Commun. 390: 1192-1196. books

Fellin T, Halassa MM, Terunuma M, Succol F, Takano H, Frank M, Moss SJ, Haydon PG. 2009. Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc Natl Acad Sci USA 106: 15037-15042. books

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