Recent Publications from the Greenblatt Lab

Research Publications Pharmacology

 

Algeelani S, Alkhelb D, Greenblatt DJ. 2018. Inhibitory effects of sulfonylureas and non-steroidal anti-inflammatory drugs on in-vitro metabolism of canagliflozin in human liver microsomes. Biopharm Drug Dispos. Epub ahead of print. Abstract in PubMed

Greenblatt DJ. 2018. Opioid prescribing: What are the numbers? Clin Pharmacol Drug Dev. 7: 6-8. Abstract in PubMed

Johnson-Agbakwu C, Brown L, Yuan J, Kissling R, Greenblatt DJ. 2017. Effects of flibanserin on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy premenopausal women: A randomized crossover study. Clin Ther. Epub ahead of print. Abstract in PubMed

Greenblatt DJ, Harmatz JS, Shader RI. 2017. Update on Psychotropic Drug Prescribing in the United States: 2014-2015. J Clin Psychopharmaol. Epub ahead of print. Abstract in PubMed

Greenblatt DJ, Patel M, Harmatz JS, Nicholson WT, Rubino CM, Chow CR. 2017. Impaired rivaroxaban clearance in mild renal insufficiency With verapamil coadministration: Potential implications for bleeding risk and dose selection. J Clin Pharmacol. Epub ahead of print. Abstract in PubMed

Alam N, Angeli MG, Greenblatt DJ.. 2017. Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir. J Pharm Pharmcol. Epub ahead of print.  Abstract in PubMed

Hossain MA, Tran T, Chen T, Mikus G, Greenblatt DJ 2017. Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat. J Pharm Pharmacol. Epub ahead of print. Abstract in PubMed

Algeelani S, Alam N, Hossain MA, Mikus G, Greenblatt DJ. 2017. In vitro inhibition of human UGT isoforms by ritonavir and cobicistat. Xenobiotica 11: 1-6. Abstract in PubMed

Cao L, Kwara A, Greenblatt DJ. 2017. Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. Epub ahead of print. Abstract in PubMed

Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. 2017. Race, gender, and genetic polymorphism contribute to variability in acetaminophen pharmacokinetics, metabolism, and protein-adduct concentrations in healthy African-American and European-American volunteers. J Pharmacol Exp Ther. 362: 431-440. Abstract in PubMed

Cao L, Greenblatt DJ, Kwara A. 2017. Inhibitory effects of selected antituberculosis drugs on common human hepatic cytochrome P450 and UDP-glucuronosyltransferase enzymes. Drug Metab Dispos. 45: 1035-1043. Abstract in PubMed

Greenblatt D. 2017. Mechanisms and consequences of drug-drug interactions. Clin Pharmacol Drug Dev. 6: 118-124. Abstract in PubMed

Schaller SJ, Alam SM, Mao J, Zhao Y, Blobner M, Greenblatt DJ, Martyn JA. 2017. Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination. J Pharm Pharmacol. 69: 82-88. Abstract in PubMed

Greenblatt HK, Greenblatt DJ. 2016. Antidepressant-associated hyponatremia in the elderly. J Clin Psychopharmacol. 36: 545-549.  Abstract in PubMed

Ng I, Greenblatt HK, Greenblatt DJ. 2016. Stereo-Psychopharmacology: The case of citalopram and escitalopram. Clin Pharmacol Drug Dev. 5: 331-335.  Abstract in PubMed

Greenblatt DJ. 2016. Evidence-based choice of ritonavir as index CYP3A inhibitor in drug-drug interaction studies. J Clin Pharmacol. 56: 152-156.  Abstract in PubMed

Elliott KR, Harmatz JS, Zhao Y, Greenblatt DJ. 2016. Body size changes among national collegiate athletic association New England Division III football players, 1956-2014: Comparison With Age-Matched Population Controls. J Athl Train. 51: 373-381.  Abstract in PubMed

Greenblatt DJ. 2016. Clinical pharmacology in drug development - an update. Clin Pharm Drug Dev. 4: 243-244.  Abstract in PubMed

Greenblatt HK, Greenblatt DJ. 2016. Meldonium (mildronate): A performance-enhancing drug? Clin Pharm Drug Dev. 5: 167-169. Abstract in PubMed

Greenblatt, DJ. 2016. A soft benzodiazepine. Clin Pharm Drug Dev. 4: 81-82.  Abstract in PubMed

Greenblatt DJ, Abourjaily PN. 2016. Pharmacokinetics and pharmacodynamics for medical students:A proposed course outline. J Clin Pharmacol. 56: 1180-1195.  Abstract in PubMed

Ratti E, Berry JD, Greenblatt DJ, Loci L, Ellrodt AS, Shefner JM, Cudkowicz ME.2015. Preclinical rodent toxicity studies for long term use of ceftriaxone. Toxicol Rep. 2:1396-1403  Abstract in PubMed

Qian Y, Sherbini A, Matin B, Zhao Y, Castellot J, Greenblatt DJ. 2015. Inhibition of 2-methoxyestradiol glucuronidation by probenecid. J Pharm Pharmacol. 67: 1585-1592.  Abstract in PubMed

Greenblatt DJ. 2015. The pharmacovigilance syndrome. J Clin Psychopharmacol. 35: 361-363. Abstract in PubMed

Greenblatt DJ, Harmatz JS. 2015. Ritonavir is the best alternative to ketoconazole as index inhibitor of Cytochrome P450-3A in drug-drug interaction studies. Brit J Clin Pharmacol. 80: 242-250. Abstract in PubMed

Zhao Y, Harmatz JS, Epstein CR, Nakagawa Y, Kurosaki C, Nakamura T, Kadota T, Giesing D, Court MH, Greenblatt DJ. 2015. Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen. Br J Clin Pharmacol. 80: 1076-1085. Abstract in PubMed

Greenblatt HK, Greenblatt DJ. 2015. Altered drug disposition following bariatric surgery: A research challenge. Clin Pharmacokinet. 54: 573-579. Abstract in PubMed

Greenblatt HK, Greenblatt DJ. 2014. Liver injury associated with ketoconazole: Review of the published evidence. J Clin Pharmacol. 54: 573-579. Abstract in PubMed

Greenblatt DJ, Harmatz JS, Singh NN, Steinberg F, Roth T, Harris SC, Kapil RP. 2014. Pharmacokinetics of zolpidem from sublingual zolpidem tartrate tablets In healthy elderly versus non-elderly subjects. Drugs Aging 31: 731-736. Abstract in PubMed

Zhao Y, Cudkowicz ME, Shefner J, Krivickas L, David WS, Vriesendorp F, Pestronk A, Caress JB, Katz J, Simpson E, Rosenfeld J, Pascuzzi R, Glass J, Rezania K, Harmatz JS, Schoenfeld D, Greenblatt DJ. 2014. Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients With amyotrophic lateral sclerosis. J Clin Pharmacol. 54: 1180-1187. Abstract in PubMed

Greenblatt DJ. 2014. In vitro prediction of clinical drug interactions with CYP3A substrates: We are not there yet. Clin Pharmacol Ther. 95: 133-135. Abstract in PubMed

Epstein LC, Masse G, Harmatz JS, Scott TM, Papas AS, Greenblatt DJ. 2014. Characterization of cognitive dysfunction in Sjögren's syndrome patients. Clin Rheumatol. 33: 511-521. Abstract in PubMed

Greenblatt DJ, Harmatz JS, Singh NN, Steinberg F, Roth T, Moline ML, Harris SC, Kapil RP. 2013. Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration. J Clin Pharmacol. 54: 282-290. Abstract in PubMed

Greenblatt DJ, Harmatz JS, Singh NN, Roth T, Harris SC, Kapil RP. 2013. Influence of food on pharmacokinetics of zolpidem from fast dissolving sublingual zolpidem tartrate tablets. J Clin Pharmacol 53: 1194-1198. Abstract in PubMed

Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group. 2013.The UDP-Glucuronosyltransferase (UGT) 1A polymorphism c.2042C.G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failures. J Pharmacol Exp Ther. 345: 297-307. Abstract in PubMed

Yasar U, Greenblatt DJ, Guillemette C, Court MH. 2013. Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers. J Pharm Pharmacol. 65: 874-883. Abstract in PubMed

Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. 2013. Effect of an herbal extract containing curcumin and piperine on midazolam, flurbiprofen, and acetaminophen pharmacokinetics in healthy volunteers. Br J Clin Pharmacol. 75: 450-462. Abstract in PubMed

Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. 2013. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 75: 1041-1052. Abstract in PubMed

Greenblatt DJ, Harmatz JS, Roth T, Singh NN, Moline ML, Harris SC, Kapil RP. 2013. Comparison of pharmacokinetic profiles of aolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: Results from a single-center, single-dose, randomized, open-label crossover study in healthy adults. Clin Ther. 35: 604-611. Abstract in PubMed

Greenblatt DJ, Zammit GK. 2012. Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications. Expert Opin Drug Metab Toxicol. 8: 1609-1618. Abstract in PubMed

Hanley MJ, Masse G, Harmatz JS, Court MH, Greenblatt DJ. 2012. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: Divergence from in vitro results. Clin Pharmacol Ther. 92: 651-657. Abstract in PubMed

Greenblatt DJ, Zammit GK. 2012. Pharmacokinetic evaluation of eszopiclone : clinical and therapeutic implications. Expert Opin Drug Metab Toxicol. 8: 1609-1618. Abstract in PubMed

Umberg EN, Shader RI, Hsu LK, Greenblatt DJ. 2012. From disordered eating to addiction: the "food drug" in bulimia nervosa. J Clin Psychopharmacol. 32: 376-389. Abstract in PubMed

Greenblatt DJ, Zhao Y, Hanley MJ, Chen C, Harmatz JS, Cancalon PF, Gmitter FG Jr. 2012. Mechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content. Xenobiotica. 42: 1163-1169. Abstract in PubMed

Greenblatt DJ, Roth T. 2012. Zolpidem for insomnia. Expert Opin Pharmacother. 13: 879-893. Abstract in PubMed

Smithline HA, Donnino M, Greenblatt DJ. 2012. Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects. BMC Clin Pharmacol. 12: 4. Abstract in PubMed

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