Recent Publications from the Sonenshein Lab

Research Publications Cell Biology


Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. 2017. UXT is a LOX-PP interacting protein that modulates estrogen receptor Alpha activity in breast cancer cells. J Biol Chem. Epub ahead of print. books

Lyons J, Polmear M, Mineva ND, Romagnoli M, Sonenshein GE, Georgakoudi I. 2016. Endogenous light scattering as an optical signature of circulating tumor cell clusters. Biomed Opt Express 7: 1042-1050. books

Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. 2016. miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Breast Cancer Res. 18:40. books

Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. 2014. N-Glycosylation regulates ADAM8 processing and activation. J Biol Chem. 289: 33676-33688. books

Bais MV, Ozdener GB, Sonenshein GE, Trackman PC. 2014. Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways. Oncogene 34: 1928-1937. books

Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg A, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. 2013. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO Mol Med. 6: 278-294. books

Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE. 2013. Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One 8: e77288. books

Mineva ND, Paulson KE, Naber SP, Yee AS, Sonenshein GE. 2013. Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells. PLoS One 8: e73464. books

Romagnoli M, Belguise K, Yu Z, Wang X, Landesman-Bollag E, Seldin DC, Chalbos D, Barillé-Nion S, Jézéquel P, Seldin ML, Sonenshein GE. 2012. Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by Blimp-1-dependent repression of BMP-5. Cancer Res. 72: 6268-6278. books

Yu Z, Sato S, Trackman PC, Kirsch KH, Sonenshein GE. 2012. Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide. PLoS One 7: e33287. books

Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. 2012. Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. PLoS One. 7: e31188. books

Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. 2011. The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase κ and inhibits β-catenin transcriptional activity in lung cancer cells. Mol Cell Biol. 31: 3286-3297. books

Sato S, Trackman PC, Mäki JM, Myllyharju J, Kirsch KH, Sonenshein GE. 2011. The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol. 31: 2683-2695. books

Min C, Zhao Y, Romagnoli M, Trackman PC, Sonenshein GE, Kirsch KH. 2010. Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis. J Cell Biochem. 111: 1160-1168. books

Vora SR, Guo Y, Stephens DN, Salih E, Vu ED, Kirsch KH, Sonenshein GE, Trackman PC. 2010. Characterization of recombinant lysyl oxidase propeptide. Biochemistry 49: 2962-2972.  books

Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX. 2010. TAp63 is a transcriptional target of NF-κB. J Cell Biochem. 109:  702-710.  books

Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, Sonenshein G, Osborne BA, Miele L. 2010. Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKα in breast cancer cells.  Oncogene 29:201-213. books

Min C, Yu Z, Kirsch KH, Zhao Y, Vora SR, Trackman PC, Spicer DB, Rosenberg L, Palmer JR, Sonenshein GE. 2009. A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.  Cancer Res. 69:6685-6693. books

Palamakumbura AH, Vora SR, Nugent MA, Kirsch KH, Sonenshein GE, Trackman PC. 2009. Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling. Oncogene 28: 3390-3400. books

Wang X, Belguise K, O'Neill CF, Sánchez-Morgan N, Romagnoli M, Eddy SF, Mineva ND, Yu Z, Min C, Trinkaus-Randall V, Chalbos D, Sonenshein GE. 2009. RelB NF-κB represses estrogen receptor α expression via induction of the zinc finger protein Blimp1. Mol Cell Biol. 29: 3832-3844. books

Mineva ND, Wang X, Yang S, Ying H, Xiao ZX, Holick MF, Sonenshein GE. 2009. Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation. J Cell Physiol. 220: 593-599. books

Zhao Y, Min C, Vora SR, Trackman PC, Sonenshein GE, Kirsch KH. 2009. The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. J Biol. Chem. 284: 1385-1393. books

Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L. 2008. Notch-1 associates with IKKα and regulates IKK activity in cervical cancer cells. Oncogene 27: 5833-5844. books

Chandramohan V, Mineva ND, Burke B, Jeay S, Wu M, Shen J, Yang W, Hann SR, Sonenshein GE. 2008. c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor. J Cell Biochem. 104: 2091-2106. books

Min C, Eddy SF, Sherr DH, Sonenshein GE. 2008. NF-κB and epithelial to mesenchymal transition of cancer. J Cell Biochem. 104: 733-744. books

Belguise K, Guo S, Yang S, Rogers AE, Seldin DC, Sherr DH, Sonenshein GE. 2007. Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Cancer Res. 67:11742-11750. books

Belguise K, Sonenshein GE. 2007. PKCΘ promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor α synthesis. J Clin Invest. 117: 4009-4021. books

Eddy SF, Kane SE, Sonenshein GE. 2007. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate. Cancer Res. 67: 9018-9023. books

Wu M, Min C, Wang X, Yu Z, Kirsch KH, Trackman PC, Sonenshein GE. 2007. Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells. Cancer Res. 67: 6278-6283. books

Belguise K, Guo S, Sonenshein GE. 2007. Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells. Cancer Res. 67: 5763-5770. books

Mineva ND, Rothstein TL, Meyers JA, Lerner A, Sonenshein GE. 2007. CD40 ligand-mediated activation of the de novo RelB NF-κB synthesis pathway in transformed B cells promotes rescue from apoptosis. J Biol Chem. 282: 17475-17485. books

Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, Galtier F, Chalbos D, Sonenshein GE. 2007. Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol. 9: 470-478. books

Min C, Kirsch KH, Zhao Y, Jeay S, Palamakumbura AH, Trackman PC, Sonenshein GE. 2007. The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer. Cancer Res. 67: 1105-1112. books   

Eddy SF, Guo S, Demicco EG, Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Sonenshein GE. 2005. Inducible IκB kinase/IκB kinase ε expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells. Cancer Res. 65: 11375-11383. books

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