Recent Publications from the Hu Lab

Research Publications Biochemistry Cell Biology


Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF. 2017. Plexin-B2 mediates physiologic and pathologic functions of angiogenin. Cell 171: 849-864. books

Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF. 2016. Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells. Cell 166: 894-906. books

Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. 2016. Cell Stem Cell Epub ahead of print. books

Jena N, Sheng J, Hu JK, Li W, Zhou W, Lee G, Tsichlis N, Pathak A, Brown N, Deshpande A, Luo C, Hu GF, Hinds PW, Van Etten RA, Hu MG. 2016. CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T cell acute lymphoblastic leukemia. Leukemia Epub ahead of print. books

Vanli N, Guo-Fu Hu. 2015. Mechanism and function of angiogenin in prostate cancer. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao. 31: 1261-1266. books

Goncalves KA, Hu GF. 2015. Mechanism and function of angiogenin in hematopoietic malignancy. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 31: 1267-1275. Abstract in PubMed

Saikia M, Jobava R, Parisien M, Putnam A, Krokowski D, Gao XH, Guan BJ, Yuan Y, Jankowsky E, Feng Z, Hu GF, Pusztai-Carey M, Gorla M, Sepuri NB, Pan T, Hatzoglou M 2014. Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 34: 2450-2463. books

Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z, Hu GF. 2014. Transcription of angiogenin and ribonuclease 4 is regulated by RNA Polymerase III elements and a CCCTC-binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem. 289: 12520-12534. books

Sheng J, Yu W, Gao X, Xu Z, Hu GF. 2014. Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter. J Cell Physiol. 229: 521-529. books

Li S, Hu MG, Sun Y, Yoshioka N, Ibaragi S, Sheng J, Sun G, Kishimoto K, Hu GF. 2013. Angiogenin mediates androgen-stimulated growth of prostate cancer cells and correlates with castration resistance. Mol Cancer Res. 11: 1203-1214. books

Pizzo E, Sarcinelli C, Sheng J, Fusco S, Formiggini F, Netti P, Yu W, D'Alessio G, Hu GF. 2013. Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin and controls its growth and survival activities. J Cell Sci. 126: 4308-4319.books

Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. 2013. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res. 73: 4337-4348. books

Li S, Sheng J, Hu JK, Yu W, Kishikawa H, Hu MG, Shima K, Wu D, Xu Z, Xin W, Sims KB, Landers JE, Brown RH Jr, Hu GF. 2012. Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. Angiogenesis 16: 387-404. books

Saikia M, Krokowski D, Guan BJ, Ivanov P, Parisien M, Hu GF, Anderson P, Pan T, Hatzoglou M. 2012. Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J Biol Chem. 287: 42708-42725. books

Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A. 2012. Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol. 48: 1120-1127. books

Li S, Hu GF.  2012. Emerging role of angiogenin in stress response and cell survival under adverse conditions. J Cell Physiol. 227: 2822-2826. books

Li S, Yu W, Hu GF. 2012. Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner. J Cell Physiol. 227: 1639-1644. books

van Es MA, Schelhaas HJ, van Vught PW, Ticozzi N, Andersen PM, Groen EJ, Schulte C, Blauw HM, Koppers M, Diekstra FP, Fumoto K, LeClerc AL, Keagle P, Bloem BR, Scheffer H, van Nuenen BF, van Blitterswijk M, van Rheenen W, Wills AM, Lowe PP, Hu GF, Yu W, Kishikawa H, Wu D, Folkerth RD, Mariani C, Goldwurm S, Pezzoli G, Van Damme P, Lemmens R, Dahlberg C, Birve A, Fernández-Santiago R, Waibel S, Klein C, Weber M, van der Kooi AJ, de Visser M, Verbaan D, van Hilten JJ, Heutink P, Hennekam EA, Cuppen E, Berg D, Brown RH Jr, Silani V, Gasser T, Ludolph AC, Robberecht W, Ophoff RA, Veldink JH, Pasterkamp RJ, de Bakker PI, Landers JE, van de Warrenburg BP, van den Berg LH. 2011. Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol. 70: 964-973. books

Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW. 2011. CDK6 kinase activity is required for thymocyte development. Blood. 117: 3120-6031. books

Yamamoto D, Shima K, Matsuo K, Nishioka T, Chen CY, Hu GF, Sasaki A, Tsuji T. 2010. Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line. PLoS One. 5: e12554. books

Li S, Hu GF. 2010. Angiogenin-mediated rRNA transcription in cancer and neurodegeneration. Int J Biochem Mol Biol. 1: 26-35. books

Chen L, Hu GF. 2010. Angiogenin-mediated ribosomal RNA transcription as a molecular target for treatment of head and neck squamous cell carcinoma. Oral Oncol. 46: 648-653. books

Li S, Yu W, Kishikawa H, Hu GF. 2010. Angiogenin prevents serum withdrawal-induced apoptosis of P19 embryonal carcinoma cells. FEBS J. 277: 3575-3587. books

Emara MM, Ivanov P, Hickman T, Dawra N, Tisdale S, Kedersha N, Hu GF, Anderson P. 2010. Angiogenin-induced tiRNA promote stress-induced stress granule assembly. J Biol Chem. 285: 10959-10968. books

Tsuji T, Ibaragi S, Hu GF. Epithelial-mesenchymal transition and cell cooperativity in metastasis. 2009. Cancer Res. 69: 7135-7139. books

Monti DM, Yu W, Pizzo E, Shima K, Hu MG, Di Malta C, Piccoli R, D’Alessio G, Hu GF. 2009. Characterization of the angiogenic activity of zebrafish ribonucleases. FEBS J. 276: 4077-4090. books

Zhou J, Huang W, Tao R, Ibaragi S, Tdo Y, Wu X, Alekseyev YO, Hu GF, Luo Z. 2009. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene 28: 1993-2002. books

Yamasaki S, Ivanov P, Hu GF, Anderson P. 2009. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol. 185: 35-42. books

Ibaragi S, Yoshioka N, Li S, Hu MG, Kishikawa S, Hu GF. 2009. Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated ribosomal RNA transcription. Clin Cancer Res. 15:1981-1988. books 

Ibaragi S, Yoshioka N, Kishikawa H, Hu JK, Sadow PM, Li M, Hu GF. Angiogenin-stimulated Ribosomal RNA Transcription Is Essential for Initiation and Survival of AKT-induced Prostate Intraepithelial Neoplasia. Mol Cancer Res. 7: 415-424. books

Hu M, Deshpande A, Enos M, Mao D, Hinds E, Hu GF, Chang R, Guo Z, Dose M, Mao C, Gounari F, Tsichlis PN, Hinds PW. 2008. A requirement for CDK6 in thymocyte development and tumorigenesis. Cancer Res 2009; 69:810-818. books

Tsuji T, Ibaragi S, Shima K, Katsurano M, Sasaki A, Hu GF. Epithelial-mesenchymal transition induced by p12CDK2-AP1 promotes invasion but suppresses metastasis. Cancer Res. 68: 10377-10386. books

Guo J, Zhu T, Ibaragi S, Luo L-Y, Hu GF, Huppi, PS, Chen CY. 2008. Nicotine promotes mammary tumor migration via a signaling cascade involving PKC and cdc42. Caner Res. 68:8473-8481. books

Kishikawa H, Wu D, Hu GF. 2008. Targeting angiogenin in therapy of amyotrophic lateral sclerosis. Expert Opinion Therapeutic Target  12: 1229-1242. books

Wang H, Leav I, Ibaragi S, Wegner M, Hu GF, Lu ML, Balk SO, Yuan X. 2008. SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion. Cancer Res. 68: 1625-30. books

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development