Recent Publications from the Freudenreich Lab

Research Publications Genetics


Zhao J, Wang G, Del Mundo IM, McKinney JA, Lu X, Bacolla A, Boulware SB, Zhang C, Zhang H, Ren P, Freudenreich CH, Vasquez KM. 2018. Distinct mechanisms of nuclease-directed DNA-structure-induced genetic instability in cancer genomes. Cell Rep. 22: 1200-1210.  books

Koch MR, House NCM, Cosetta CM, Jong RM, Salomon CG, Joyce CE, Philips EA, Su XA, Freudenreich CH. 2018. The chromatin remodeler Isw1 prevents CAG repeat expansions during transcription in Saccharomyces cerevisiae. Genetics Epub ahead of print. books

Freudenreich CH. 2018. R-loops: targets for nuclease cleavage and repeat instability. Curr Genet. Epub ahead of print. books

Polleys EJ, Freudenreich CH. 2017. Methods to study repeat fragility and instability in Saccharomyces cerevisiae. Methods Mol Biol. 1672: 403-419.  books

Su XA, Freudenreich CH. 2017. Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae. Proc Natl Acad Sci USA Epub ahead of print.  books

Polleys EJ, House NCM, Freudenreich CH. 2017. Role of recombination and replication fork restart in repeat instability. DNA Repair 56: 156-165. books

Nguyen JH, Viterbo D, Anand RP, Verra L, Sloan L, Richard GF, Freudenreich CH. 2017. Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats. Nucleic Acids Res. 45: 4519-4531. books

Freudenreich CH, Su XA. 2016. Relocalization of DNA lesions to the nuclear pore complex. FEMS Yeast Res. 16 (8). books

Su XA, Dion V, Gasser SM, Freudenreich CH. 2015. Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability. Genes Dev.  29:1006-1017. books

House NC, Koch MR, Freudenreich CH 2014. Chromatin modifications and DNA repair: beyond double-strand breaks. Front Genet. 5: 296. books

House NC, Yang JH, Walsh SC, Moy JM, Freudenreich CH. 2014. NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps. Mol Cell 55: 818-828. books

Frizzell A, Nguyen JH, Petalcorin MI, Turner KD, Boulton SJ, Freudenreich CH, Lahue RS. 2014. RTEL1 inhibits trinucleotide repeat expansions and fragility. Cell Rep. 6: 827-823. books

Anand RP, Shah KA, Niu H, Sung P, Mirkin SM, Freudenreich CH. 2012. Overcoming natural replication barriers: differential helicase requirements. Nucleic Acids Res. 40: 1091-1105. books

Sundararajan R, Freudenreich CH. 2011. Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae. PLoS Genetics 7: e1001339. books

Gellon L, Razidlo DF, Gleeson O, Verra L, Schulz D, Lahue RS, Freudenreich CH. 2011. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion. PLoS Genetics 7: e1001298. books

Cherng N, Shishkin AA, Schlager LI, Tuck RH, Sloan L, Matera R, Sarkar PS, Ashizawa T, Freudenreich CH, Mirkin SM. 2011. Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast. Proc Natl Acad Sci USA 108: 2843-2848. books

Yang JH, Freudenreich CH. 2010. The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions. DNA Repair 9: 414-420. books

Sundararajan R, Gellon L, Zunder RM, Freudenreich CH. 2010. Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae. Genetics 184: 65-77. books

Voineagu I, Freudenreich CH, Mirkin SM. 2009. Checkpoint responses to unusual structures formed by DNA repeats. Mol Carcinog. 48: 309-318. books

Kerrest A, Anand RP, Sundararajan R, Bermejo R, Liberi G, Dujon B, Freudenreich CH, Richard GF. 2009. SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination. Nat Struct Biol. 16: 159-167. books

Zhang H, Freudenreich CH. 2007. An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae. Mol Cell 27: 367-379. books 

Freudenreich CH. 2007. Chromosome fragility: molecular mechanisms and cellular consequences. Front Biosci. 12: 4911-4924. books

Yang J, Freudenreich CH. 2007. Haploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner. Gene 393: 110-115. books

Freudenreich CH, Lahiri M. 2004. Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases. Ceel Cycle 1370-1374. books

Lahiri M, Gustafson TL, Majors ER, Freudenreich CH. 2004. Expanded CAG repeats activate the DNA damage checkpoint pathway. Mol Cell 15: 287-293. books

Liu Y, Zhang H, Veeraraghavan J, Bambara RA, Freudenreich CH. 2004. Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Mol Cell Biol. 24: 4049-4064. books

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