Recent Publications from the Forgac Lab

Research Publications Cell Biology


McGuire C, Stransky L, Cotter K, Forgac M. 2017. Regulation of V-ATPase actiity. Front Biosci. 22:609-622.  Abstract in PubMed

Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M. 2016. The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget Epub ahead of print.   Abstract in PubMed

Stransky L, Cotter K, Forgac M. 2016. The Function of V-ATPases in cancer. Physiol Rev. 96: 1071-1091.  Abstract in PubMed

McGuire C, Cotter K, Stransky L, Forgac M. 2016. Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness. Biochim Biophys Acta Epub ahead of print.  Abstract in PubMed

Cotter K, Stransky L, McGuire C, Forgac M. 2015. Recent insights into the structure, regulation, and function of the V-ATPases. Trends Biochem Sci. 40: 611-622.   Abstract in PubMed

Stransky LA, Forgac M. 2015. Amino acid availability modulates vacuolar H+-ATPase assembly. J Biol. Chem. 290: 27360-27369.   Abstract in PubMed

Cotter K, Capecci J, Sennoune S, Huss M, Maier M, Martinez-Zaguilan R, Forgac M. 2014. Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells. J Biol Chem. 290: 3680-3692. Abstract in PubMed

Liberman R, Bond S, Shainheit MG, Stadecker MJ, Forgac M. 2014. Regulated assembly of the V-ATPase is increased during cluster disruption-induced maturation of dendritic cells through a PI-3 Kinase/mTOR-dependent pathway. J Biol Chem. 289: 1355-1362. Abstract in PubMed

Capecci J, Forgac M. 2013. J Biol Chem. Function of V-ATPase a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. 288: 32731-32741. Abstract in PubMed

Liberman R, Cotter K, Baleja JD, Forgac M. 2013. Structural analysis of the N-terminal domain of subunit a of the yeast vacuolar ATPase (V-ATPase) using accessibility of single cysteine substitutions to chemical modification. J Biol Chem. 288: 22798-22808. Abstract in PubMed

Toei M, Toei S, Forgac M.  2011. Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase. J Biol Chem. 286: 35176-35186. Abstract in PubMed

Toei M, Saum R, Forgac M. 2010. Regulation and isoform function of the V-ATPases. Biochemistry 49: 4715-4723. Abstract in PubMed

O'Callaghan KM, Ayllon V, O'Keeffe J, Wang Y, Cox OT, Loughran G, Forgac M, O'Connor R. 2010. Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. J Biol Chem. 285: 381-391. Abstract in PubMed

Hinton A, Sennoune SR, Bond S, Fang M, Reuveni M, Sahagian GG, Jay D, Martinez-Zaguilan R, Forgac M. 2009. Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells. J Biol Chem. 284: 16400-16408. Abstract in PubMed

Hinton A, Bond S, Forgac M.  2009. V-ATPase functions in normal and disease processes. Pflugers Arch. 457: 589-598. Abstract in PubMed

Bond S, Forgac M. 2008. The Ras/cAMP/protein kinase A pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeast. J Biol Chem. 283: 36513-36521.  Abstract in PubMed

Wang Y, Toei M, Forgac M. 2008. Analysis of the membrane topology of transmembrane segments in the C-terminal hydrophobic domain of the yeast vacuolar ATPase subunit a (Vph1p) by chemical modification. J Biol Chem. 283: 20696-20702. books

Qi J, Forgac M. 2008. Function and subunit interactions of the N-terminal domain of subunit a (Vph1p) of the yeast V-ATPase. J Biol Chem 283: 19274-19282. Abstract in PubMed

Jefferies KC, Forgac M. 2008. Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F.  J Biol Chem. 283: 4512-4519.  Abstract in PubMed

Qi J, Wang Y, Forgac M. 2007. The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation. J Bioenerg Biomembr. 39: 423-426. books

Kawasaki-Nishi S, Yamaguchi A, Forgac M, Nishi T. 2007. Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit. Biochem Biophys Res Commun. 364: 1032-1036. books

Forgac M. 2007. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat Rev Mol Cell Biol. 8: 917-929. books

Wang Y, Cipriano DJ, Forgac M. 2007. Arrangement of subunits in the proteolipid ring of the V-ATPase.J Biol Chem. 282: 34058-34065. books

Qi J, Forgac M. 2007. Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.J Biol Chem. 282: 24743-24751. books

Zhang Z, InoueT, Forgac M,  Wilkens S. 2006. Localization of subunit C (Vma5p) in the yeast vacuolar ATPase by immunoelectron microscopy. FEBS Lett. 580: 2006-2010. books

Wang Y, Inoue T, Forgac M. 2005. Subunit a of the yeast V-ATPase participates in bafilomycin binding. J Biol Chem. 280: 40481-40488. books

Inoue T, Forgac M. 2005. Cysteine-mediated cross-linking indicates that subunit C of the V-ATPase is in close proximity to subunits E and G of the V1 domain and subunit a of the V0 domain. J Biol Chem. 280: 27896-27903. books

Shen R, Inoue T, Forgac M, Porco JA Jr. 2005. Synthesis of photoactivatable acyclic analogues of the lobatamides J Org Chem. 70: 3686-3692. books

Shao E, Forgac M. 2004. Involvement of the mon-homologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.  J Biol Chem. 279: 48663-48670. books

Wang Y, Inoue T, Forgac M. 2004.  TM2 but not TM4 of subunit c' interacts with TM7 of subunit a of the yeast V-ATPase as defined by disulfide-mediated cross-linking J Biol Chem. 279: 44628-44638. books

Wilkens S, Inoue T, Forgac M. 2004. Three-dimensional structure of the vacuolar ATPase - localization of subunit H by difference imaging and chemical cross-linking J Biol Chem. 279: 41942-41949. books

Kawasaki-Nishi S, Nishi T, Forgac M. 2003.  Interacting helical surfaces of the transmembrane segments of subunits a and c’ of the yeast V-ATPase defined by disilfide-mediated cross-linking. J Biol Chem. 278: 41908-41913. books

Nishi T, Kawasaki-Nishi S, Forgac M. 2003. Expression and function of the mouse V-ATPase d subunit isoforms. J Biol Chem. 278: 46396-46402. books

Shao E, Nishi T, Kawasaki-Nishi S, Forgac M. 2003. Mutational analysis of the non-homologous region of subunit A of the yeast V-ATPase. J Biol Chem. 278: 12985-12991. books

Nishi T, Kawasaki-Nishi S, Forgac M. 2003. The first putative transmembrane segment of subunit c' (Vma16p) of the yeast V-ATPase is not necessary for function. J Biol Chem. 278: 5821-5827. books

Nishi T, Forgac M. 2002. The Vacuolar (H+)-ATPases: Nature's most versatile proton pumps. Nat Rev Mol Cell Biol 3: 94-103. books

Arata Y, Baleja J, Forgac M. 2002. Localization of subunits D, E and G in the yeast V-ATPase complex using cysteine-mediated crosslinking to subunit B. Biochemistry 41: 11301-11307. books

Arata Y, Baleja JD, Forgac M. 2002. Cysteine-directed crosslinking to subunit B suggests that subunit E forms part of the peripheral stalk of theV-ATPase. J Biol Chem. 277: 3357-3363. books

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